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Gene · 4359

MPZ: myelin protein zero

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MPZ: myelin protein zero. Genes, record 4359. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4359

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Gene

Symbol
MPZ
HGNC
Name
myelin protein zero
HGNC
NCBI Gene ID
4359
NCBI Gene
HGNC ID
HGNC:7225
HGNC
Ensembl
ENSG00000158887
NCBI Gene
Aliases
CMT1, CMT1B, CMT2I, CMT2J, CMT4E, CMTDI3, CMTDID, DSS, HMSNIB, MPP, P0
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25189Myelin protein P02482Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454387P25189Espacenet
JP 2026004568 A2026-01-1454388P25189Espacenet
EP 4650780 A22025-11-1915430P25189Espacenet
EP 4650780 A22025-11-1975378P25189Espacenet
JP 2025529142 A2025-09-042686P25189Espacenet
US 12371689 B22025-07-292686P25189Espacenet
JP 2025517970 A2025-06-1215430P25189Espacenet
JP 2025517970 A2025-06-1275378P25189Espacenet
JP 2025032204 A2025-03-1131779P25189Espacenet
JP 2025032204 A2025-03-1131780P25189Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants694

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMPZ papersNewest fiscal year
T32GM007526Medical Genetics Research Fellowship Program42025
ZIANS003129Molecular and Clinical Manifestations of Matrix and Aggregate Myopathies42025
R01DC017461Engineering multi-lineage inner ear organoids32025
R01NS028840Mitogenic Activities in Neurofibromatosis32025
R01NS072248Genome Studies in Hereditary Spastic Paraplegia- Beyond the Exome32025
U24DC013983NIDCD National Temporal Bone Hearing and Balance Pathology Resource Registry32025
P30CA062203Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30EY025580Multidisciplinary Investigations in Visual Science22025
R01EY024605Choriocapillaris Protection and Replacement in AMD22025

1 to 10 of 694Source NIH's project files

See all 694 nih grants

Papers1,500

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Late-onset CMT neuropathy in the NGS era: a 10-year retrospective study.J Neurol202642799779PubTator, text miningPubMed
A Reproducible Transcriptomic Program of Neurofibroma-to-Malignant Peripheral Nerve Sheath Tumor Transformation.Genes Chromosomes Cancer202642765715PubTator, text miningPubMed
Bioactive keratin-pectin methacrylate multifilament nerve conduits for functional regeneration across segmental nerve defects.Int J Biol Macromol202642748994PubTator, text miningPubMed
A Case Report of a Novel Myelin Protein Zero (MPZ) Pathogenic Variant in Charcot-Marie-Tooth Disease Combined With Type 2 Diabetes.Case Rep Genet202642732363PubTator, text miningPubMed
Unveiling novel transcriptomic prognostic biomarkers for specific breast cancer subtypes and treatment regimens.Pharmacol Rep202642714781PubTator, text miningPubMed
[Clinical pattern and evolution of Charcot-Marie-Tooth disease in pediatrics].Medicina (B Aires)202642659543PubTator, text miningPubMed
Hereditary Polyneuropathy Experience of a Tertiary Single-Center in Türkiye: Beyond the Tip of the Iceberg.Clin Genet202642552261PubTator, text miningPubMed
Case Report: Schwann cell reprogramming and PDGF-driven nerve hypertrophy in an NF1 patient with CIDP-like autoimmunity.Front Immunol202642539570PubTator, text miningPubMed
High-Resolution Ultrasound Evaluation of Nerves and Muscles at Multiple Sites in Charcot-Marie-Tooth Disease.J Ultrasound Med202642435318PubTator, text miningPubMed
Functional disease progression in children with inherited peripheral neuropathies: A prospective cohort study.J Neuromuscul Dis202642396985PubTator, text miningPubMed

1 to 10 of 1,500

See all 1,500 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4359

GET https://conductscience.org/api/genes/v1/4359/patents?page=2