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ASNS: asparagine synthetase (glutamine-hydrolyzing)
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Gene · 440

Papers1,669

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 1,669

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TitleJournalYearPMIDFound bySource
α-aminobutyric acid promotes tumor progression by polarizing macrophages through the ASNS-mTORC2 axis.Proc Natl Acad Sci U S A202642814553PubTator, text miningPubMed
Asparagine Synthetase Deficiency: Neuropathological Evidence of Disrupted Cortical Development.JIMD Rep202642741518PubTator, text miningPubMed
GPT2 enhances colorectal cancer cell growth, movement, and invasion by altering gene expression patterns.Tissue Cell202642691609PubTator, text miningPubMed
Disulfidptosis- and Ferroptosis-Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction.Kaohsiung J Med Sci202642690169PubTator, text miningPubMed
Integrative bulk and single-cell transcriptomics identify a recurrence-prognostic risk model with exploratory associations with treatment-response phenotypes in colorectal cancer.Hum Cell202642606648PubTator, text miningPubMed
Asparagine synthetase deficiency: clinical features and experience with asparagine supplementation.J Pediatr Endocrinol Metab202642568280PubTator, text miningPubMed
IGSF3 drives acquired temozolomide resistance in glioblastoma through ASNS-dependent asparagine biosynthesis.J Biol Chem202642486263PubTator, text miningPubMed
The MAPK/ATF3/ASNS axis drives amino acid metabolic reprogramming to promote NSCLC survival under glucose deprivation.J Transl Med202642436529PubTator, text miningPubMed
Exploring key genes and prognostic validation of prostate cancer through transcriptome-wide association study.Sci Rep202642401728PubTator, text miningPubMed
From ALL to Myeloid and NK Malignancies: Operationalizing "ASNS-Low" for L-Asparaginase Repurposing and Combination Therapy.Biomolecules202642352259PubTator, text miningPubMed
A missense variant in Exon 9 of the ASNS gene causes splicing abnormality in an Infant with asparagine synthetase deficiency.Front Genet202642283035PubTator, text miningPubMed
Targeting ATF3-mediated asparagine biosynthesis reverses acquired resistance to KRASG12C inhibitors.Oncogene202642270775PubTator, text miningPubMed
Direct pharmacological targeting of asparagine synthetase to overcome resistance to L-asparaginase in ALL therapy.JCI Insight202642241118PubTator, text miningPubMed
The Role of NADPH Oxidase 4 in Neutrophil-Mediated Immune Escape in Gastric Cancer.Int J Biol Sci202642157942PubTator, text miningPubMed
Identification of biomarkers related to amino acid metabolism in nonobstructive azoospermia by bioinformatics.Medicine (Baltimore)202642065147PubTator, text miningPubMed
METTL1-mediated m7G modification of ASNS mRNA regulates asparagine metabolism reprogramming to promote hepatocellular carcinoma progression.Oncogene202642045536PubTator, text miningPubMed
Suppression of ASNS expression by VHL-mediated ubiquitination hinders the progression of renal cell carcinoma through enhancing JUP expression and inhibiting PI3K-AKT and MAPK pathways.Int J Biol Sci202641943831PubTator, text miningPubMed
A Workflow for Visualizing Protein Conformational Dynamics from Cryo-EM Maps Using Human Asparagine Synthetase.J Vis Exp202641941364PubTator, text miningPubMed
Fueling silence: Metabolic control of latent viral infection.PLoS Pathog202641920818PubTator, text miningPubMed
Multi-omics profiling links enhancer-associated MSH6 downregulation to platinum resistance, prognosis, and immune features in ovarian cancer.Gene202641911956PubTator, text miningPubMed

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  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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