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Gene · 440

ASNS: asparagine synthetase (glutamine-hydrolyzing)

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ASNS: asparagine synthetase (glutamine-hydrolyzing). Genes, record 440. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/440

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Gene

Symbol
ASNS
HGNC
Name
asparagine synthetase (glutamine-hydrolyzing)
HGNC
NCBI Gene ID
440
NCBI Gene
HGNC ID
HGNC:753
HGNC
Ensembl
ENSG00000070669
NCBI Gene
Aliases
ASNSD, TS11
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08243Asparagine synthetase [glutamine-hydrolyzing]5613Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1437945P08243Espacenet
JP 2026004568 A2026-01-1437946P08243Espacenet
JP 2026004568 A2026-01-1437947P08243Espacenet
EP 4650780 A22025-11-19154P08243Espacenet
EP 4641201 A22025-10-29124P08243Espacenet
EP 4641202 A22025-10-294293P08243Espacenet
JP 2025517969 A2025-06-12124P08243Espacenet
JP 2025517970 A2025-06-12154P08243Espacenet
JP 2025062604 A2025-04-146669P08243Espacenet
JP 2025062604 A2025-04-146670P08243Espacenet

1 to 10 of 48

See all 48 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,237

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleASNS papersNewest fiscal year
P30CA016672Cancer Center Support Grant222025
P30CA008748Cancer Center Support Grant152025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30CA016086Cancer Center Support Grant52025
UL1TR001863Yale Clinical and Translational Science Award52025
ZIADA000618Cellular mechanisms of neuronal dysfunction in addiction and neurodegeneration52025
P30CA010815Consolidated Basic Cancer Research Program42025
P30CA016058Cancer Center Support Grant42025
P30CA033572Cancer Center Support Grant42025
P30ES010126UNC Center for Environmental Health and Susceptibility42025

1 to 10 of 1,237Source NIH's project files

See all 1,237 nih grants

Papers1,669

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
α-aminobutyric acid promotes tumor progression by polarizing macrophages through the ASNS-mTORC2 axis.Proc Natl Acad Sci U S A202642814553PubTator, text miningPubMed
Asparagine Synthetase Deficiency: Neuropathological Evidence of Disrupted Cortical Development.JIMD Rep202642741518PubTator, text miningPubMed
GPT2 enhances colorectal cancer cell growth, movement, and invasion by altering gene expression patterns.Tissue Cell202642691609PubTator, text miningPubMed
Disulfidptosis- and Ferroptosis-Related Gene Signatures in Rheumatoid Arthritis: Association Analysis and Diagnostic Model Construction.Kaohsiung J Med Sci202642690169PubTator, text miningPubMed
Integrative bulk and single-cell transcriptomics identify a recurrence-prognostic risk model with exploratory associations with treatment-response phenotypes in colorectal cancer.Hum Cell202642606648PubTator, text miningPubMed
Asparagine synthetase deficiency: clinical features and experience with asparagine supplementation.J Pediatr Endocrinol Metab202642568280PubTator, text miningPubMed
IGSF3 drives acquired temozolomide resistance in glioblastoma through ASNS-dependent asparagine biosynthesis.J Biol Chem202642486263PubTator, text miningPubMed
The MAPK/ATF3/ASNS axis drives amino acid metabolic reprogramming to promote NSCLC survival under glucose deprivation.J Transl Med202642436529PubTator, text miningPubMed
Exploring key genes and prognostic validation of prostate cancer through transcriptome-wide association study.Sci Rep202642401728PubTator, text miningPubMed
From ALL to Myeloid and NK Malignancies: Operationalizing "ASNS-Low" for L-Asparaginase Repurposing and Combination Therapy.Biomolecules202642352259PubTator, text miningPubMed

1 to 10 of 1,669

See all 1,669 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/440

GET https://conductscience.org/api/genes/v1/440/patents?page=2