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EIF2AK4: eukaryotic translation initiation factor 2 alpha kinase 4
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Gene · 440275

Papers3,229

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 3,229

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TitleJournalYearPMIDFound bySource
Substrate Binding Relieves Autoinhibition of the Mammalian GCN2 Kinase.bioRxiv202642818380PubTator, text miningPubMed
Conformational diversity of collided ribosomes determines stress signaling.bioRxiv202642818177PubTator, text miningPubMed
Impaired BMPR2 signalling across pulmonary hypertension subgroups: a multicentre study.ERJ Open Res202642807825PubTator, text miningPubMed
Impaired Mevalonate-Dependent NAD⁺ Regeneration Suppresses Serine Biosynthesis and Enhances Sensitivity to PHGDH Inhibition.Cancer Res202642804747PubTator, text miningPubMed
Batch- and Composition-Controlled Reanalysis of Bulk and Single-Nucleus Transcriptomes Reveals Co-Enrichment of Glial Complement and of Translational Signatures in Parkinson's Disease and Amyotrophic Lateral Sclerosis.
Int J Mol Sci202642794442PubTator, text miningPubMed
Beyond Translation Initiation: Translational Elongation, Decoding Fidelity, and Ribosome Surveillance During Branched-Chain Amino Acid Deprivation, with a Focus on Mammalian Systems.Biology (Basel)202642792574PubTator, text miningPubMed
Diaphragmatic Mitochondrial Myopathy in a Patient-Derived Mouse Model of Barth Syndrome.J Dev Biol202642783548PubTator, text miningPubMed
The kynurenine pathway in RNA virus infection: immunometabolic control of antiviral defense and viral persistence.Front Immunol202642769543PubTator, text miningPubMed
Persistent Airway Uric Acid is Associated with Epithelial Stress Signaling and Macrophage Inflammatory Activation in COPD.J Inflamm Res202642751184PubTator, text miningPubMed
Programmed ribosomal frameshifting triggers translational stress to promote viral replication.Cell202642743925PubTator, text miningPubMed
Integrated multi-omics identification of m6A-SNP-related diagnostic biomarkers in amyotrophic lateral sclerosis.Front Immunol202642723774PubTator, text miningPubMed
Amino Acid Metabolism in Health and Disease.MedComm (2020)202642666691PubTator, text miningPubMed
Mathematical modeling of dietary timing- and protein quality-responsive liver circadian clock and its function on ribosome biogenesis.Physiol Genomics202642647400PubTator, text miningPubMed
Codon Optimality Modulates Cellular Stress and Innate Immune Responses Triggered by Exogenous RNAs.J Mol Biol202642617995PubTator, text miningPubMed
The integrated stress response kinase GCN2 prevents ZAKα-Dependent inflammatory hyperactivation in macrophages.J Biol Chem202642600662PubTator, text miningPubMed
A genetic approach to identify amino acids in human GCN1 required for mediating Gcn2 activation.MicroPubl Biol202642582883PubTator, text miningPubMed
Microenvironmental arginine restriction sensitizes pancreatic cancers to polyunsaturated fatty acids by suppression of lipid synthesis.Elife202642554218PubTator, text miningPubMed
Pulmonary Veno-Occlusive Disease: A Focused Clinicopathologic Series.Pulm Circ202642516692PubTator, text miningPubMed
Translational resistance to amino acid starvation in breast cancer cells revealed by ribosome profiling.iScience202642491850PubTator, text miningPubMed
Cystine Restriction Alleviates T-cell Exhaustion and Enhances CAR T-cell Potency.Cancer Res202642479884PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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