Gene · 440275
EIF2AK4: eukaryotic translation initiation factor 2 alpha kinase 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EIF2AK4: eukaryotic translation initiation factor 2 alpha kinase 4. Genes, record 440275. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/440275
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9P2K8 | eIF-2-alpha kinase GCN2 | 1,649 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026027383 A | 2026-02-18 | 35 | Q9P2K8 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1823 | Q9P2K8 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1823 | Q9P2K8 | Espacenet |
| US 12171820 B2 | 2024-12-24 | 1 | Q9P2K8 | Espacenet |
| JP 2023507989 A | 2023-02-28 | 35 | Q9P2K8 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 4939 | Q9P2K8 | Espacenet |
| JP 2022141755 A | 2022-09-29 | 773 | Q9P2K8 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28612 | Q9P2K8 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 131583 | Q9P2K8 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3454 | Q9P2K8 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,284
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EIF2AK4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 10 | 2025 |
| ZIAHD001004 | Molecular Mechanisms of Translational Control | 10 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| P30DK072476 | Pennington/Louisiana NORC | 9 | 2025 |
| R01DK060596 | Translational control by nutrients | 9 | 2025 |
| U19AI057266 | Vaccine and Infection Induced Immunity in the Young and Aged | 8 | 2025 |
| P30CA016520 | Abramson Cancer Center Support Grant | 7 | 2025 |
| R01NS095892 | IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY | 7 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 2,284Source NIH's project files
See all 2,284 nih grantsPapers3,229
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Substrate Binding Relieves Autoinhibition of the Mammalian GCN2 Kinase. | bioRxiv | 2026 | 42818380 | PubTator, text mining | PubMed |
| Conformational diversity of collided ribosomes determines stress signaling. | bioRxiv | 2026 | 42818177 | PubTator, text mining | PubMed |
| Impaired BMPR2 signalling across pulmonary hypertension subgroups: a multicentre study. | ERJ Open Res | 2026 | 42807825 | PubTator, text mining | PubMed |
| Impaired Mevalonate-Dependent NAD⁺ Regeneration Suppresses Serine Biosynthesis and Enhances Sensitivity to PHGDH Inhibition. | Cancer Res | 2026 | 42804747 | PubTator, text mining | PubMed |
Batch- and Composition-Controlled Reanalysis of Bulk and Single-Nucleus Transcriptomes Reveals Co-Enrichment of Glial Complement and of Translational Signatures in Parkinson's Disease and Amyotrophic Lateral Sclerosis. | Int J Mol Sci | 2026 | 42794442 | PubTator, text mining | PubMed |
| Beyond Translation Initiation: Translational Elongation, Decoding Fidelity, and Ribosome Surveillance During Branched-Chain Amino Acid Deprivation, with a Focus on Mammalian Systems. | Biology (Basel) | 2026 | 42792574 | PubTator, text mining | PubMed |
| Diaphragmatic Mitochondrial Myopathy in a Patient-Derived Mouse Model of Barth Syndrome. | J Dev Biol | 2026 | 42783548 | PubTator, text mining | PubMed |
| The kynurenine pathway in RNA virus infection: immunometabolic control of antiviral defense and viral persistence. | Front Immunol | 2026 | 42769543 | PubTator, text mining | PubMed |
| Persistent Airway Uric Acid is Associated with Epithelial Stress Signaling and Macrophage Inflammatory Activation in COPD. | J Inflamm Res | 2026 | 42751184 | PubTator, text mining | PubMed |
| Programmed ribosomal frameshifting triggers translational stress to promote viral replication. | Cell | 2026 | 42743925 | PubTator, text mining | PubMed |
1 to 10 of 3,229
See all 3,229 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/440275
GET https://conductscience.org/api/genes/v1/440275/patents?page=2