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Gene · 440275

EIF2AK4: eukaryotic translation initiation factor 2 alpha kinase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF2AK4: eukaryotic translation initiation factor 2 alpha kinase 4. Genes, record 440275. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/440275

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Gene

Symbol
EIF2AK4
HGNC
Name
eukaryotic translation initiation factor 2 alpha kinase 4
HGNC
NCBI Gene ID
440275
NCBI Gene
HGNC ID
HGNC:19687
HGNC
Ensembl
ENSG00000128829
NCBI Gene
Aliases
GCN2, KIAA1338, PVOD2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9P2K8eIF-2-alpha kinase GCN21,6499Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026027383 A2026-02-1835Q9P2K8Espacenet
EP 4641201 A22025-10-291823Q9P2K8Espacenet
JP 2025517969 A2025-06-121823Q9P2K8Espacenet
US 12171820 B22024-12-241Q9P2K8Espacenet
JP 2023507989 A2023-02-2835Q9P2K8Espacenet
US 11564998 B22023-01-314939Q9P2K8Espacenet
JP 2022141755 A2022-09-29773Q9P2K8Espacenet
US 11446398 B22022-09-2028612Q9P2K8Espacenet
JP 2022524081 A2022-04-27131583Q9P2K8Espacenet
US 11078247 B22021-08-033454Q9P2K8Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,284

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF2AK4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant132025
P30CA030199Cancer Center Support Grant (CCSG)102025
ZIAHD001004Molecular Mechanisms of Translational Control102025
P30CA016672Cancer Center Support Grant92025
P30DK072476Pennington/Louisiana NORC92025
R01DK060596Translational control by nutrients92025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged82025
P30CA016520Abramson Cancer Center Support Grant72025
R01NS095892IMPACTING MITOCHONDRIAL FUNCTION THROUGH ALTERED PROTEASE ACTIVITY72025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025

1 to 10 of 2,284Source NIH's project files

See all 2,284 nih grants

Papers3,229

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Substrate Binding Relieves Autoinhibition of the Mammalian GCN2 Kinase.bioRxiv202642818380PubTator, text miningPubMed
Conformational diversity of collided ribosomes determines stress signaling.bioRxiv202642818177PubTator, text miningPubMed
Impaired BMPR2 signalling across pulmonary hypertension subgroups: a multicentre study.ERJ Open Res202642807825PubTator, text miningPubMed
Impaired Mevalonate-Dependent NAD⁺ Regeneration Suppresses Serine Biosynthesis and Enhances Sensitivity to PHGDH Inhibition.Cancer Res202642804747PubTator, text miningPubMed
Batch- and Composition-Controlled Reanalysis of Bulk and Single-Nucleus Transcriptomes Reveals Co-Enrichment of Glial Complement and of Translational Signatures in Parkinson's Disease and Amyotrophic Lateral Sclerosis.
Int J Mol Sci202642794442PubTator, text miningPubMed
Beyond Translation Initiation: Translational Elongation, Decoding Fidelity, and Ribosome Surveillance During Branched-Chain Amino Acid Deprivation, with a Focus on Mammalian Systems.Biology (Basel)202642792574PubTator, text miningPubMed
Diaphragmatic Mitochondrial Myopathy in a Patient-Derived Mouse Model of Barth Syndrome.J Dev Biol202642783548PubTator, text miningPubMed
The kynurenine pathway in RNA virus infection: immunometabolic control of antiviral defense and viral persistence.Front Immunol202642769543PubTator, text miningPubMed
Persistent Airway Uric Acid is Associated with Epithelial Stress Signaling and Macrophage Inflammatory Activation in COPD.J Inflamm Res202642751184PubTator, text miningPubMed
Programmed ribosomal frameshifting triggers translational stress to promote viral replication.Cell202642743925PubTator, text miningPubMed

1 to 10 of 3,229

See all 3,229 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/440275

GET https://conductscience.org/api/genes/v1/440275/patents?page=2