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MSH2: mutS homolog 2

1 protein, 119 patents, 0 drugs, 0 trials, 5,079 NIH grants and 16,932 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMSH2HGNC
NamemutS homolog 2HGNC
NCBI Gene ID4436NCBI Gene
HGNC IDHGNC:7325HGNC
EnsemblENSG00000095002NCBI Gene
AliasesCOCA1, FCC1, HNPCC, HNPCC1, LCFS2, LYNCH1, MMRCS2, MSH-2, hMSH2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P43246DNA mismatch repair protein Msh293430Ensembl, GeneID, HGNCUniProt

Patents 119

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4709870 A12026-03-18163P43246Espacenet
EP 4650780 A22025-11-19846P43246Espacenet
EP 4641201 A22025-10-29594P43246Espacenet
WO 2025177214 A12025-08-2842P43246Espacenet
JP 2025517969 A2025-06-12594P43246Espacenet
JP 2025517970 A2025-06-12846P43246Espacenet
JP 2024543481 A2024-11-21163P43246Espacenet
EP 4464338 A22024-11-20348P43246Espacenet
EP 4430207 A12024-09-18163P43246Espacenet
JP 2024123008 A2024-09-107144P43246Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5079

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2472,025NIH's project files
P30CA016672Cancer Center Support Grant1992,025NIH's project files
P30CA016058Cancer Center Support Grant1092,025NIH's project files
R01CA067007Mismatch Repair and Carcinogenesis652,025NIH's project files
P30CA006973Regional Oncology Research Center612,025NIH's project files
P30CA015704Cancer Center Support Grant532,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant472,025NIH's project files
U01CA167551Colon Cancer Family Registry Cohort432,025NIH's project files
R01GM050006Enzymology of Mismatch Repair in Yeast412,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award352,025NIH's project files

Papers 16932

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824376PubTator, text miningPubMed
42821536PubTator, text miningPubMed
42818672PubTator, text miningPubMed
42810221PubTator, text miningPubMed
42809727PubTator, text miningPubMed
42809083PubTator, text miningPubMed
42802819PubTator, text miningPubMed
42801369PubTator, text miningPubMed
42798460PubTator, text miningPubMed
42798309PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license