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Gene · 4437

MSH3: mutS homolog 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MSH3: mutS homolog 3. Genes, record 4437. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4437

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Gene

Symbol
MSH3
HGNC
Name
mutS homolog 3
HGNC
NCBI Gene ID
4437
NCBI Gene
HGNC ID
HGNC:7326
HGNC
Ensembl
ENSG00000113318
NCBI Gene
Aliases
DUP, FAP4, MRP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20585DNA mismatch repair protein Msh31,13725Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-192437P20585Espacenet
EP 4641201 A22025-10-292020P20585Espacenet
JP 2025147176 A2025-10-068969P20585Espacenet
JP 2025529142 A2025-09-047081P20585Espacenet
US 12371689 B22025-07-297081P20585Espacenet
JP 2025517969 A2025-06-122020P20585Espacenet
JP 2025517970 A2025-06-122437P20585Espacenet
JP 2025028160 A2025-02-288969P20585Espacenet
KR 1020250010750 A2025-01-218969P20585Espacenet
EP 4464338 A22024-11-20350P20585Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,942

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMSH3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant342025
P30CA016672Cancer Center Support Grant302025
P01CA092584Structural Cell Biology of DNA Repair Machines222025
R01GM050006Enzymology of Mismatch Repair in Yeast202025
R01CA067007Mismatch Repair and Carcinogenesis172025
R01CA093729Repair of Genome Destabilizing DNA Structures152025
P30CA016058Cancer Center Support Grant122025
ZIADK057808Understanding the mutational mechanism responsible for the Repeat Expansion Diseases102025
R01NS049206Huntington's Disease Repeat Instability and Pathogenesis92025
P30ES010126UNC Center for Environmental Health and Susceptibility72025

1 to 10 of 1,942Source NIH's project files

See all 1,942 nih grants

Papers3,191

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
[Mechanism of Apoptosis for Corynoline-Mediated Reversing the Drug Resistance of AML HL-60/ADR Cells].Zhongguo Shi Yan Xue Ye Xue Za Zhi202642802433PubTator, text miningPubMed
Integrated Molecular Profiling of Endometrial Cancer: NGS Findings, MSI/MMR Status, Histopathological Features, and TCGA-Inspired Molecular Classification.Biomedicines202642792624PubTator, text miningPubMed
Heterozygous germline mutations in MSH3, and probably MLH3, act as classical tumour suppressors, leading to excess somatic deletion mutations, signature ID4 and increased colorectal cancer risk.Gut202642728028PubTator, text miningPubMed
Unscheduled DNA synthesis reveals a DNA repair hotspot and biomarker of somatic instability at the expanded-CAG repeat tract in the huntingtin gene.bioRxiv202642619847PubTator, text miningPubMed
DNA Repair Pathway Variants Are Enriched in Individuals with Biallelic AAGGG CANVAS and RFC1-Related Disease.Mov Disord202642473260PubTator, text miningPubMed
Tissue-specific CTG•CAG expansion rate and disease severity are modified by DNA repair genes expression levels in myotonic dystrophy type 1 patients.DNA Repair (Amst)202642419013PubTator, text miningPubMed
A Case of Pancreatic Cancer with High Tumor Mutation Burden Showing a Remarkable Response to Pembrolizumab.Surg Case Rep202642404091PubTator, text miningPubMed
Mismatch repair dissection by in vivo RNAi reveals dose-dependent modulators of somatic instability and proteome remodeling in Huntington's disease.bioRxiv202642395360PubTator, text miningPubMed
Clinical and genomic characteristics of primary resistant disease to first-line immuno-oncology plus VEGFR inhibitor therapy in metastatic renal cell carcinoma.Sci Rep202642380403PubTator, text miningPubMed
Somatic CRISPR editing of Msh3 mitigates Huntington's disease pathology in mice.bioRxiv202642327018PubTator, text miningPubMed

1 to 10 of 3,191

See all 3,191 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4437

GET https://conductscience.org/api/genes/v1/4437/patents?page=2