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Gene · 445

ASS1: argininosuccinate synthase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ASS1: argininosuccinate synthase 1. Genes, record 445. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/445

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Gene

Symbol
ASS1
HGNC
Name
argininosuccinate synthase 1
HGNC
NCBI Gene ID
445
NCBI Gene
HGNC ID
HGNC:758
HGNC
Ensembl
ENSG00000130707
NCBI Gene
Aliases
ASS, CTLN1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P00966Argininosuccinate synthase4121Ensembl, GeneID, HGNC

Source UniProt

Patents122

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-2177P00966Espacenet
WO 2025265017 A12025-12-261P00966Espacenet
WO 2025255199 A12025-12-111P00966Espacenet
EP 4650780 A22025-11-191423P00966Espacenet
JP 2025169942 A2025-11-14830P00966Espacenet
JP 2025169942 A2025-11-14831P00966Espacenet
JP 2025169942 A2025-11-14833P00966Espacenet
JP 2025169942 A2025-11-14834P00966Espacenet
EP 4641202 A22025-10-294460P00966Espacenet
US 12385065 B22025-08-121P00966Espacenet

1 to 10 of 122

See all 122 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,983

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleASS1 papersNewest fiscal year
P30CA008748Cancer Center Support Grant152025
P30CA016672Cancer Center Support Grant122025
P30CA093373Cancer Center Support Grant P30112025
T32GM007526Medical Genetics Research Fellowship Program92025
P20GM109025Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission82025
P30CA033572Cancer Center Support Grant82025
P30CA010815Consolidated Basic Cancer Research Program72025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions42025
P30CA014599Cancer Center Support Grant42025
P30CA091842Cancer Center Support Grant42025

1 to 10 of 1,983Source NIH's project files

See all 1,983 nih grants

Papers3,531

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
High-Density Type I Collagen Promotes IFN-γ+ CD8+ T Cell Exhaustion via SAT1-ASS1-Mediated Glutamine Accumulation and Ferroptosis in Triple-Negative Breast Cancer.Adv Sci (Weinh)202642801687PubTator, text miningPubMed
Comparative Gene Expression Analysis of Epithelioid Pleural and Peritoneal Mesothelioma.Cancers (Basel)202642794985PubTator, text miningPubMed
Myokardinfarkt: Es geht wohl nicht ohne ASS.MMW Fortschr Med202642786326PubTator, text miningPubMed
Sustained hypoxia induces divergent response patterns in cardiac metabolic-immune adaptation and circadian rhythm regulation.PLoS One202642726733PubTator, text miningPubMed
ASS1-derived argininosuccinate promotes purine nucleoside synthesis in B cell acute lymphoblastic leukaemia.Nat Metab202642706347PubTator, text miningPubMed
An Exopolysaccharide from Lactiplantibacillus plantarum ZGS521 Alleviates Colitis via Gut Microbiota Modulation and Enhanced Arginine Biosynthesis.J Agric Food Chem202642677610PubTator, text miningPubMed
T cell receptor repertoire dynamics and newly identified functional regulators of autologous tumor-infiltrating lymphocyte therapy in advanced solid tumors.J Transl Med202642618927PubTator, text miningPubMed
A Metabo-Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21-Arginine Axis.Adv Mater202642554227PubTator, text miningPubMed
Single-cell profiling uncovers extracellular vesicle-associated malignant plasma cell subpopulations driving multiple myeloma progression.Front Immunol202642529293PubTator, text miningPubMed
Neonatal Acute Liver Failure due to Citrin Deficiency (NALFCD).JIMD Rep202642494745PubTator, text miningPubMed

1 to 10 of 3,531

See all 3,531 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/445

GET https://conductscience.org/api/genes/v1/445/patents?page=2