Gene · 445
ASS1: argininosuccinate synthase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ASS1: argininosuccinate synthase 1. Genes, record 445. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/445
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P00966 | Argininosuccinate synthase | 412 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents122
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 77 | P00966 | Espacenet |
| WO 2025265017 A1 | 2025-12-26 | 1 | P00966 | Espacenet |
| WO 2025255199 A1 | 2025-12-11 | 1 | P00966 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1423 | P00966 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 830 | P00966 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 831 | P00966 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 833 | P00966 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 834 | P00966 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4460 | P00966 | Espacenet |
| US 12385065 B2 | 2025-08-12 | 1 | P00966 | Espacenet |
1 to 10 of 122
See all 122 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,983
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ASS1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 15 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 12 | 2025 |
| P30CA093373 | Cancer Center Support Grant P30 | 11 | 2025 |
| T32GM007526 | Medical Genetics Research Fellowship Program | 9 | 2025 |
| P20GM109025 | Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission | 8 | 2025 |
| P30CA033572 | Cancer Center Support Grant | 8 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 7 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 4 | 2025 |
| P30CA014599 | Cancer Center Support Grant | 4 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,983Source NIH's project files
See all 1,983 nih grantsPapers3,531
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| High-Density Type I Collagen Promotes IFN-γ+ CD8+ T Cell Exhaustion via SAT1-ASS1-Mediated Glutamine Accumulation and Ferroptosis in Triple-Negative Breast Cancer. | Adv Sci (Weinh) | 2026 | 42801687 | PubTator, text mining | PubMed |
| Comparative Gene Expression Analysis of Epithelioid Pleural and Peritoneal Mesothelioma. | Cancers (Basel) | 2026 | 42794985 | PubTator, text mining | PubMed |
| Myokardinfarkt: Es geht wohl nicht ohne ASS. | MMW Fortschr Med | 2026 | 42786326 | PubTator, text mining | PubMed |
| Sustained hypoxia induces divergent response patterns in cardiac metabolic-immune adaptation and circadian rhythm regulation. | PLoS One | 2026 | 42726733 | PubTator, text mining | PubMed |
| ASS1-derived argininosuccinate promotes purine nucleoside synthesis in B cell acute lymphoblastic leukaemia. | Nat Metab | 2026 | 42706347 | PubTator, text mining | PubMed |
| An Exopolysaccharide from Lactiplantibacillus plantarum ZGS521 Alleviates Colitis via Gut Microbiota Modulation and Enhanced Arginine Biosynthesis. | J Agric Food Chem | 2026 | 42677610 | PubTator, text mining | PubMed |
| T cell receptor repertoire dynamics and newly identified functional regulators of autologous tumor-infiltrating lymphocyte therapy in advanced solid tumors. | J Transl Med | 2026 | 42618927 | PubTator, text mining | PubMed |
| A Metabo-Reprogramming Niche Remodeling System Halts Osteoarthritis by Restoring the FGF21-Arginine Axis. | Adv Mater | 2026 | 42554227 | PubTator, text mining | PubMed |
| Single-cell profiling uncovers extracellular vesicle-associated malignant plasma cell subpopulations driving multiple myeloma progression. | Front Immunol | 2026 | 42529293 | PubTator, text mining | PubMed |
| Neonatal Acute Liver Failure due to Citrin Deficiency (NALFCD). | JIMD Rep | 2026 | 42494745 | PubTator, text mining | PubMed |
1 to 10 of 3,531
See all 3,531 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/445
GET https://conductscience.org/api/genes/v1/445/patents?page=2