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Gene · 4486

MST1R: macrophage stimulating 1 receptor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MST1R: macrophage stimulating 1 receptor. Genes, record 4486. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4486

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Gene

Symbol
MST1R
HGNC
Name
macrophage stimulating 1 receptor
HGNC
NCBI Gene ID
4486
NCBI Gene
HGNC ID
HGNC:7381
HGNC
Ensembl
ENSG00000164078
NCBI Gene
Aliases
CD136, CDw136, NPCA3, PTK8, RON, SEA, p185-Ron
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q04912Macrophage-stimulating protein receptor1,4004Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-193727Q04912Espacenet
EP 4640849 A22025-10-29482Q04912Espacenet
EP 4641201 A22025-10-293306Q04912Espacenet
JP 2025529142 A2025-09-042723Q04912Espacenet
US 12371689 B22025-07-292723Q04912Espacenet
JP 2025519096 A2025-06-24482Q04912Espacenet
JP 2025517969 A2025-06-123306Q04912Espacenet
JP 2025517970 A2025-06-123727Q04912Espacenet
US 11446398 B22022-09-2048021Q04912Espacenet
US 11400116 B22022-08-022656Q04912Espacenet

1 to 10 of 26

See all 26 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CRIZOTINIBCHEMBL601719Macrophage-stimulating protein receptor inhibitorINHIBITORChEMBL
GLESATINIBCHEMBL3989914Macrophage-stimulating protein receptor inhibitorINHIBITORChEMBL
MK-8033CHEMBL2323775Macrophage-stimulating protein receptor inhibitorINHIBITORChEMBL
NARNATUMABCHEMBL1743046Macrophage-stimulating protein receptor inhibitorINHIBITORChEMBL

Trials96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07560410CRIZOTINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07207278CRIZOTINIBClinicalTrials.gov
NCT06563999CRIZOTINIBPHASE2ClinicalTrials.gov
NCT06360575CRIZOTINIBPHASE22026-03-20ClinicalTrials.gov
NCT06357975CRIZOTINIBPHASE22026-03-19ClinicalTrials.gov
NCT06140836CRIZOTINIBPHASE3ClinicalTrials.gov
NCT05987332CRIZOTINIBPHASE2/PHASE3ClinicalTrials.gov
NCT05834348CRIZOTINIB2025-03-30ClinicalTrials.gov
NCT05792644CRIZOTINIBClinicalTrials.gov
NCT05725200CRIZOTINIBPHASE2ClinicalTrials.gov

1 to 10 of 96

See all 96 trials

NIH grants1,173

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMST1R papersNewest fiscal year
I01BX000803Ron Receptor Tyrosine Kinase Signaling in Breast Cancer252025
P30CA008748Cancer Center Support Grant122025
P30CA016672Cancer Center Support Grant112025
P30CA054174Mays Cancer Center at UT Health SA82025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease62025
T32CA121938UCSD Cancer Center Training Program in Drug Development62025
P01CA013106Targeting Transcription and Splicing in Cancer52025
P30CA016086Cancer Center Support Grant52025
P30CA042014Cancer Center Support Grant52025
P30CA047904Cancer Center Support Grant52025

1 to 10 of 1,173Source NIH's project files

See all 1,173 nih grants

Papers1,924

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discovery of quinoline-based derivatives as c-Met inhibitors for the treatment of non-small cell lung cancer.Eur J Med Chem202642748863PubTator, text miningPubMed
Pharmaceutical Potential of Antibody-Drug Conjugate Doublets for Targeted Treatment of Cancers Heterogeneously Expressing RON Receptor Tyrosine Kinase.Curr Cancer Drug Targets202642693721PubTator, text miningPubMed
RON receptor tyrosine kinase regulates abiraterone resistance in prostate cancer via the methylation-dependent and independent dual functions of DNMT1.Oncogene202642498731PubTator, text miningPubMed
Genome-wide pleiotropic analysis identifies shared genetic architecture within the cognition-immune nexus.Transl Psychiatry202642386713PubTator, text miningPubMed
Antibody-drug conjugates in colorectal cancer: molecular design, preclinical advances, and translational challenges.Cancer Chemother Pharmacol202642207299PubTator, text miningPubMed
Relation of Osteopontin Expression to Tumor-Associated Macrophages-Derived Transforming Growth Factor Beta 1 Expression in Non-small Cell Lung Carcinoma.J Microsc Ultrastruct202642040212PubTator, text miningPubMed
Investigation of molecular immune regulation mechanisms and therapeutic target prediction in pancreatic cancer based on bioinformatics and genetics.Clinics (Sao Paulo)202642001564PubTator, text miningPubMed
Expression and Clinical Significance of Pim-1 and RON in Lung Cancer Patients with Benign and Malignant Pleural Effusion.Clin Lab202641979639PubTator, text miningPubMed
Osteosarcoma cells promote intracellular iron detoxification to mitigate GPX4-mediated ferroptosis.Cancer Gene Ther202641872463PubTator, text miningPubMed
Genomic landscape of pleural mesothelioma in Japanese patients: A comprehensive analysis using nationwide database.Transl Oncol202641855858PubTator, text miningPubMed

1 to 10 of 1,924

See all 1,924 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4486

GET https://conductscience.org/api/genes/v1/4486/patents?page=2