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Gene · 4488

MSX2: msh homeobox 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MSX2: msh homeobox 2. Genes, record 4488. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4488

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Gene

Symbol
MSX2
HGNC
Name
msh homeobox 2
HGNC
NCBI Gene ID
4488
NCBI Gene
HGNC ID
HGNC:7392
HGNC
Ensembl
ENSG00000120149
NCBI Gene
Aliases
CRS2, FPP, HOX8, MSH, PFM, PFM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P35548Homeobox protein MSX-22670Ensembl, GeneID, HGNC

Source UniProt

Patents39

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454114P35548Espacenet
EP 4650780 A22025-11-19990P35548Espacenet
JP 2025147176 A2025-10-0615311P35548Espacenet
JP 2025517970 A2025-06-12990P35548Espacenet
JP 2025032204 A2025-03-1131812P35548Espacenet
JP 2025028160 A2025-02-2815311P35548Espacenet
KR 1020250010750 A2025-01-2115311P35548Espacenet
EP 4461818 A22024-11-1331812P35548Espacenet
JP 2024109657 A2024-08-1415150P35548Espacenet
JP 2023058610 A2023-04-2531812P35548Espacenet

1 to 10 of 39

See all 39 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,792

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMSX2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
R01CA067007Mismatch Repair and Carcinogenesis82025
P30CA008748Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant52025
K12HD001271Colorado Women's Reproductive Health Research Career Development Center42025
P01CA092584Structural Cell Biology of DNA Repair Machines42025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment42025
R01HD068524Molecular signaling in uterine receptivity to implantation42025
R35GM119465Unraveling mechanisms of genome regulation to understand and improvehuman health42025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant32025

1 to 10 of 1,792Source NIH's project files

See all 1,792 nih grants

Papers2,792

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Two Unrelated Families With Noncoding Duplications Upstream of MSX2 Refine the Critical Regulatory Region Likely Involved in Cranial Bone Development and a Cleidocranial Dysplasia-Like Phenotype.Hum Mutat202642609732PubTator, text miningPubMed
Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci.HGG Adv202642482381PubTator, text miningPubMed
Breast cancer risk genes affecting individual radiosensitivity.Sci Rep202642289459PubTator, text miningPubMed
Type E endothelial cells orchestrate embryonic skeletogenesis via chondrogenic priming of skeletal progenitors.J Orthop Translat202642182072PubTator, text miningPubMed
Uncovering the role of the PPR protein PHOTOSYSTEM ONE BIOGENESIS FACTOR6 in splicing chloroplast group II introns.J Integr Plant Biol202642135903PubTator, text miningPubMed
Evidence-based classification of genes implicated in craniosynostosis disorders using the ClinGen curation framework.Genet Med202642059179PubTator, text miningPubMed
Raman spectroscopy enables highly sensitive profiling of osteogenic mineralization in periodontal organoids.Arch Oral Biol202642019144PubTator, text miningPubMed
BMP4 signaling regulates the expression of signals and transcription factors for coordinated cytodifferentiation in the murine ureter.Biochem J202642017529PubTator, text miningPubMed
Neurobiology of language in autism: a systematic review of pediatric studies.Brain Imaging Behav202641880035PubTator, text miningPubMed
Molecular Origin of Correlated Bath Effects in Photoinduced Charge Transfer Dynamics in Polar Solvents.J Phys Chem Lett202641838668PubTator, text miningPubMed

1 to 10 of 2,792

See all 2,792 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4488

GET https://conductscience.org/api/genes/v1/4488/patents?page=2