Gene · 4504
MT3: metallothionein 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MT3: metallothionein 3. Genes, record 4504. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4504
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P25713 | Metallothionein-3 | 68 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents44
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026088121 A | 2026-05-28 | 7 | P25713 | Espacenet |
| US 12560619 B2 | 2026-02-24 | 30 | P25713 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 53325 | P25713 | Espacenet |
| EP 4596042 A2 | 2025-08-06 | 7 | P25713 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 31820 | P25713 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 31820 | P25713 | Espacenet |
| US 12038446 B2 | 2024-07-16 | 30 | P25713 | Espacenet |
| US 12000843 B2 | 2024-06-04 | 12 | P25713 | Espacenet |
| JP 2024028454 A | 2024-03-04 | 7 | P25713 | Espacenet |
| US 11866488 B2 | 2024-01-09 | 7 | P25713 | Espacenet |
1 to 10 of 44
See all 44 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants787
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MT3 papers | Newest fiscal year |
|---|---|---|---|
| R35GM128704 | Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteins | 6 | 2025 |
| P20GM103442 | ND INBRE Health & the Environment | 4 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 3 | 2025 |
| P30CA091842 | Cancer Center Support Grant | 3 | 2025 |
| R01ES007331 | Mechanisms of Methylmercury Induced Neuronal Toxicity | 3 | 2025 |
| R01ES010563 | Mechanisms of Manganese Neurotoxicity | 3 | 2025 |
| T32ES007126 | Pre- and Postdoctoral Training in Toxicology | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA051008 | Georgetown University Lombardi Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 787Source NIH's project files
See all 787 nih grantsPapers1,807
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Metallothionein Isoforms in Acute Myeloid Leukemia: Roles in Survival, Differentiation, and Stress Adaptation. | Hematol Rep | 2026 | 42776828 | PubTator, text mining | PubMed |
| Increased markers of heavy metal exposure and DNA methylation in cluster headache. | Cephalalgia | 2026 | 42640585 | PubTator, text mining | PubMed |
| Integrative Transcriptomics Across Etiologies Reveals Common and Disease-Specific Fibrogenic Signatures in Liver Fibrosis. | Can J Gastroenterol Hepatol | 2026 | 42415271 | PubTator, text mining | PubMed |
| Zinc-binding protein metallothionein 3 protects vascular smooth muscle cells from ferroptosis via blocking lysosomal degradation of GPX4. | J Mol Med (Berl) | 2026 | 42334628 | PubTator, text mining | PubMed |
| MT3-KN035 Nanoparticles Based on PD-L1 Nanobodies Allow for Multiple Drug Conjugations that Promote Chemo- and Immunosynergistic Therapies. | ACS Biomater Sci Eng | 2026 | 42334414 | PubTator, text mining | PubMed |
| Novel variants in YTHDC2 cause non-obstructive azoospermia by disrupting the mitotic-to-meiotic transition in humans and mice. | Hum Reprod | 2026 | 42249589 | PubTator, text mining | PubMed |
| Targeting mitochondrial metabolism in renal cell carcinoma with melatonin: Preclinical evidence and clinical perspectives. | Tissue Cell | 2026 | 42229285 | PubTator, text mining | PubMed |
| Immunometabolic control of cytokine production by micronutrients in health, aging, and inflammation. | Front Immunol | 2026 | 42164494 | PubTator, text mining | PubMed |
| Structural domain plasticity drives Zn(II) distribution and buffering in metallothionein-3. | Chem Commun (Camb) | 2026 | 42003720 | PubTator, text mining | PubMed |
| The evolutionary history of chelicerate metallothioneins reveals de novo emergence and metal-binding specialization across the subphylum. | Sci Rep | 2026 | 41876545 | PubTator, text mining | PubMed |
1 to 10 of 1,807
See all 1,807 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4504
GET https://conductscience.org/api/genes/v1/4504/patents?page=2