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Gene · 4504

MT3: metallothionein 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MT3: metallothionein 3. Genes, record 4504. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4504

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Gene

Symbol
MT3
HGNC
Name
metallothionein 3
HGNC
NCBI Gene ID
4504
NCBI Gene
HGNC ID
HGNC:7408
HGNC
Ensembl
ENSG00000087250
NCBI Gene
Aliases
GIF, GIFB, GRIF, ZnMT3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P25713Metallothionein-3683Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026088121 A2026-05-287P25713Espacenet
US 12560619 B22026-02-2430P25713Espacenet
JP 2026004568 A2026-01-1453325P25713Espacenet
EP 4596042 A22025-08-067P25713Espacenet
JP 2025032204 A2025-03-1131820P25713Espacenet
EP 4461818 A22024-11-1331820P25713Espacenet
US 12038446 B22024-07-1630P25713Espacenet
US 12000843 B22024-06-0412P25713Espacenet
JP 2024028454 A2024-03-047P25713Espacenet
US 11866488 B22024-01-097P25713Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants787

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMT3 papersNewest fiscal year
R35GM128704Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteins62025
P20GM103442ND INBRE Health & the Environment42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
P30CA091842Cancer Center Support Grant32025
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity32025
R01ES010563Mechanisms of Manganese Neurotoxicity32025
T32ES007126Pre- and Postdoctoral Training in Toxicology32025
P30CA008748Cancer Center Support Grant22025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant22025
P30CA072720Cancer Center Support Grant22025

1 to 10 of 787Source NIH's project files

See all 787 nih grants

Papers1,807

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Metallothionein Isoforms in Acute Myeloid Leukemia: Roles in Survival, Differentiation, and Stress Adaptation.Hematol Rep202642776828PubTator, text miningPubMed
Increased markers of heavy metal exposure and DNA methylation in cluster headache.Cephalalgia202642640585PubTator, text miningPubMed
Integrative Transcriptomics Across Etiologies Reveals Common and Disease-Specific Fibrogenic Signatures in Liver Fibrosis.Can J Gastroenterol Hepatol202642415271PubTator, text miningPubMed
Zinc-binding protein metallothionein 3 protects vascular smooth muscle cells from ferroptosis via blocking lysosomal degradation of GPX4.J Mol Med (Berl)202642334628PubTator, text miningPubMed
MT3-KN035 Nanoparticles Based on PD-L1 Nanobodies Allow for Multiple Drug Conjugations that Promote Chemo- and Immunosynergistic Therapies.ACS Biomater Sci Eng202642334414PubTator, text miningPubMed
Novel variants in YTHDC2 cause non-obstructive azoospermia by disrupting the mitotic-to-meiotic transition in humans and mice.Hum Reprod202642249589PubTator, text miningPubMed
Targeting mitochondrial metabolism in renal cell carcinoma with melatonin: Preclinical evidence and clinical perspectives.Tissue Cell202642229285PubTator, text miningPubMed
Immunometabolic control of cytokine production by micronutrients in health, aging, and inflammation.Front Immunol202642164494PubTator, text miningPubMed
Structural domain plasticity drives Zn(II) distribution and buffering in metallothionein-3.Chem Commun (Camb)202642003720PubTator, text miningPubMed
The evolutionary history of chelicerate metallothioneins reveals de novo emergence and metal-binding specialization across the subphylum.Sci Rep202641876545PubTator, text miningPubMed

1 to 10 of 1,807

See all 1,807 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4504

GET https://conductscience.org/api/genes/v1/4504/patents?page=2