Gene · 4507
MTAP: methylthioadenosine phosphorylase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MTAP: methylthioadenosine phosphorylase. Genes, record 4507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4507
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13126 | S-methyl-5'-thioadenosine phosphorylase | 283 | 18 | Ensembl, GeneID, HGNC |
Source UniProt
Patents24
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 53403 | Q13126 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 19405 | Q13126 | Espacenet |
| WO 2025217297 A1 | 2025-10-16 | 1 | Q13126 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 19405 | Q13126 | Espacenet |
| JP 2023509516 A | 2023-03-08 | 4 | Q13126 | Espacenet |
| US 11591579 B2 | 2023-02-28 | 1 | Q13126 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 50991 | Q13126 | Espacenet |
| KR 1020220124718 A | 2022-09-14 | 1 | Q13126 | Espacenet |
| US 11396647 B2 | 2022-07-26 | 1 | Q13126 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 153962 | Q13126 | Espacenet |
1 to 10 of 24
See all 24 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,298
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MTAP papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 37 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 13 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 9 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 8 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 7 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 7 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 7 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 6 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 5 | 2025 |
1 to 10 of 1,298Source NIH's project files
See all 1,298 nih grantsPapers2,281
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| MTAP loss upregulates BCAT1 in pancreatic cancer and drives branched-chain amino acid dependency. | Cell Rep | 2026 | 42814576 | PubTator, text mining | PubMed |
| Genomic Landscape of Primary and Secondary Cutaneous Angiosarcoma: A Single-Center Retrospective Cohort Analysis in Japan. | J Dermatol | 2026 | 42810841 | PubTator, text mining | PubMed |
| Digital PCR for Detecting Loss of BAP1 and MTAP in Pleural Fluids of Mesothelioma Patients: Perspectives in the Diagnosis. | Pathol Int | 2026 | 42801547 | PubTator, text mining | PubMed |
| Contemporary Landscape of Active Clinical Trials in Pancreatic Ductal Adenocarcinoma: A ClinicalTrials.gov-Based Narrative Review with a Scoping Approach. | Pharmaceuticals (Basel) | 2026 | 42797417 | PubTator, text mining | PubMed |
| Metabolomics and Machine Learning Uncover 5'-Methylthioadenosine as a Metabolic Indicator of Mixed-Pattern Drug-Induced Liver Injury. | Metabolites | 2026 | 42783739 | PubTator, text mining | PubMed |
| Interrupted surveillance and delayed genetic evaluation in neurofibromatosis type 1 associated with advanced malignant peripheral nerve sheath tumor and breast cancer: A case report. | Int Cancer Conf J | 2026 | 42781021 | PubTator, text mining | PubMed |
| Immunohistochemistry Resolves Indeterminate MTAP Deletion Calls From Exome Sequencing: A Pan-Cancer Concordance Study. | Mod Pathol | 2026 | 42778110 | PubTator, text mining | PubMed |
| CDKN2A/B status can be assessed by p16/MTAP immunohistochemistry as a practical surrogate in pleomorphic xanthoastrocytoma and high-grade astrocytoma with piloid features. | J Neuropathol Exp Neurol | 2026 | 42777114 | PubTator, text mining | PubMed |
| Catalytical nanogels reprogram immunosuppressive metabolic networks for activatable cancer photo-immunotherapy. | J Control Release | 2026 | 42767374 | PubTator, text mining | PubMed |
| Low frequency of MTAP co-deletion with CDKN2A in peritoneal mesothelioma suggests an independent diagnostic role for MTAP. | Histopathology | 2026 | 42766860 | PubTator, text mining | PubMed |
1 to 10 of 2,281
See all 2,281 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4507
GET https://conductscience.org/api/genes/v1/4507/patents?page=2