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Gene · 4507

MTAP: methylthioadenosine phosphorylase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MTAP: methylthioadenosine phosphorylase. Genes, record 4507. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4507

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Gene

Symbol
MTAP
HGNC
Name
methylthioadenosine phosphorylase
HGNC
NCBI Gene ID
4507
NCBI Gene
HGNC ID
HGNC:7413
HGNC
Ensembl
ENSG00000099810
NCBI Gene
Aliases
BDMF, DMSFH, DMSMFH, HEL-249, LGMBF, MSAP, c86fus
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13126S-methyl-5'-thioadenosine phosphorylase28318Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453403Q13126Espacenet
EP 4650780 A22025-11-1919405Q13126Espacenet
WO 2025217297 A12025-10-161Q13126Espacenet
JP 2025517970 A2025-06-1219405Q13126Espacenet
JP 2023509516 A2023-03-084Q13126Espacenet
US 11591579 B22023-02-281Q13126Espacenet
US 11446398 B22022-09-2050991Q13126Espacenet
KR 1020220124718 A2022-09-141Q13126Espacenet
US 11396647 B22022-07-261Q13126Espacenet
JP 2022524081 A2022-04-27153962Q13126Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,298

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMTAP papersNewest fiscal year
P30CA008748Cancer Center Support Grant372025
P30CA006927Comprehensive Cancer Center Program at Fox Chase132025
P30CA016672Cancer Center Support Grant132025
P30CA016086Cancer Center Support Grant92025
P30ES010126UNC Center for Environmental Health and Susceptibility82025
P30CA006973Regional Oncology Research Center72025
P30CA013330Cancer Center Support Grant72025
P30CA016056Roswell Park Cancer Center Support Grant72025
P30CA016058Cancer Center Support Grant62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025

1 to 10 of 1,298Source NIH's project files

See all 1,298 nih grants

Papers2,281

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MTAP loss upregulates BCAT1 in pancreatic cancer and drives branched-chain amino acid dependency.Cell Rep202642814576PubTator, text miningPubMed
Genomic Landscape of Primary and Secondary Cutaneous Angiosarcoma: A Single-Center Retrospective Cohort Analysis in Japan.J Dermatol202642810841PubTator, text miningPubMed
Digital PCR for Detecting Loss of BAP1 and MTAP in Pleural Fluids of Mesothelioma Patients: Perspectives in the Diagnosis.Pathol Int202642801547PubTator, text miningPubMed
Contemporary Landscape of Active Clinical Trials in Pancreatic Ductal Adenocarcinoma: A ClinicalTrials.gov-Based Narrative Review with a Scoping Approach.Pharmaceuticals (Basel)202642797417PubTator, text miningPubMed
Metabolomics and Machine Learning Uncover 5'-Methylthioadenosine as a Metabolic Indicator of Mixed-Pattern Drug-Induced Liver Injury.Metabolites202642783739PubTator, text miningPubMed
Interrupted surveillance and delayed genetic evaluation in neurofibromatosis type 1 associated with advanced malignant peripheral nerve sheath tumor and breast cancer: A case report.Int Cancer Conf J202642781021PubTator, text miningPubMed
Immunohistochemistry Resolves Indeterminate MTAP Deletion Calls From Exome Sequencing: A Pan-Cancer Concordance Study.Mod Pathol202642778110PubTator, text miningPubMed
CDKN2A/B status can be assessed by p16/MTAP immunohistochemistry as a practical surrogate in pleomorphic xanthoastrocytoma and high-grade astrocytoma with piloid features.J Neuropathol Exp Neurol202642777114PubTator, text miningPubMed
Catalytical nanogels reprogram immunosuppressive metabolic networks for activatable cancer photo-immunotherapy.J Control Release202642767374PubTator, text miningPubMed
Low frequency of MTAP co-deletion with CDKN2A in peritoneal mesothelioma suggests an independent diagnostic role for MTAP.Histopathology202642766860PubTator, text miningPubMed

1 to 10 of 2,281

See all 2,281 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4507

GET https://conductscience.org/api/genes/v1/4507/patents?page=2