Gene · 4520
MTF1: metal regulatory transcription factor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MTF1: metal regulatory transcription factor 1. Genes, record 4520. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4520
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14872 | Metal regulatory transcription factor 1 | 753 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents21
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 53330 | Q14872 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15315 | Q14872 | Espacenet |
| JP 2025121934 A | 2025-08-20 | 5 | Q14872 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15315 | Q14872 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15315 | Q14872 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15154 | Q14872 | Espacenet |
| JP 2022551987 A | 2022-12-14 | 27 | Q14872 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 50674 | Q14872 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 153645 | Q14872 | Espacenet |
| JP 2021536249 A | 2021-12-27 | 15508 | Q14872 | Espacenet |
1 to 10 of 21
See all 21 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants676
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MTF1 papers | Newest fiscal year |
|---|---|---|---|
| R35GM118086 | Mechanistic studies of nucleic acid enzymes involved in DNA replication, transcription, and innate immunity | 6 | 2025 |
| R01ES007331 | Mechanisms of Methylmercury Induced Neuronal Toxicity | 4 | 2025 |
| R01ES010563 | Mechanisms of Manganese Neurotoxicity | 4 | 2025 |
| R01AR077578 | Mechanisms of Cu-binding factors to promote myogenic gene expression | 3 | 2025 |
| R35GM139644 | lluminating the biochemistry of zinc and RNA in live cells | 3 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 2 | 2025 |
| P40OD010440 | Caenorhabditis Genetics Center | 2 | 2025 |
| R01AI101171 | Host-mediated zinc sequestration during Acinetobacter baumannii infection | 2 | 2025 |
| R01AR063759 | Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state | 2 | 2025 |
| R01CA068682 | Biomedical Applications of Expanded Porphyrins | 2 | 2025 |
1 to 10 of 676Source NIH's project files
See all 676 nih grantsPapers1,378
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The KDM6 histone H3K27me3 demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells. | RSC Chem Biol | 2026 | 42597942 | PubTator, text mining | PubMed |
| Contrasting Effects of HT-2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism. | J Biochem Mol Toxicol | 2026 | 42533448 | PubTator, text mining | PubMed |
| Identification of ITGB2, ELN, and KLRK1 as stress granule-related biomarkers of pterygium through integrated transcriptomic analysis and machine learning. | Biochem Biophys Res Commun | 2026 | 42447550 | PubTator, text mining | PubMed |
| Cuproptosis: A Potential Target for the Treatment of Systemic Lupus Erythematosus. | J Inflamm Res | 2026 | 42445351 | PubTator, text mining | PubMed |
| Analysis of end-stage renal disease mediated by cuproptosis-related genes. | Clin Nephrol | 2026 | 42383521 | PubTator, text mining | PubMed |
| Low Zinc Ameliorated the Decrease in Intestinal Copper Level Induced by Low Dietary Copper: Involvement of SUMOylated-Mtf-1 and Mtf-1/Atp7a Pathway. | FASEB J | 2026 | 42257536 | PubTator, text mining | PubMed |
| The PBAF chromatin remodeling complex contributes to metal homeostasis through MTF1 regulation. | Metallomics | 2026 | 42246576 | PubTator, text mining | PubMed |
| FDX1 as a predictive biomarker and therapeutic target for lymph node metastasis in gastric cancer. | Clin Exp Med | 2026 | 42107026 | PubTator, text mining | PubMed |
| Multifaceted Role of Copper Homeostasis in Gut Health: From Molecular Mechanisms to Therapeutic Interventions. | Cells | 2026 | 41892335 | PubTator, text mining | PubMed |
| Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications. | Signal Transduct Target Ther | 2026 | 41881983 | PubTator, text mining | PubMed |
1 to 10 of 1,378
See all 1,378 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4520
GET https://conductscience.org/api/genes/v1/4520/patents?page=2