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Gene · 4520

MTF1: metal regulatory transcription factor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MTF1: metal regulatory transcription factor 1. Genes, record 4520. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4520

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Gene

Symbol
MTF1
HGNC
Name
metal regulatory transcription factor 1
HGNC
NCBI Gene ID
4520
NCBI Gene
HGNC ID
HGNC:7428
HGNC
Ensembl
ENSG00000188786
NCBI Gene
Aliases
MTF-1, ZRF
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14872Metal regulatory transcription factor 17530Ensembl, GeneID, HGNC

Source UniProt

Patents21

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453330Q14872Espacenet
JP 2025147176 A2025-10-0615315Q14872Espacenet
JP 2025121934 A2025-08-205Q14872Espacenet
JP 2025028160 A2025-02-2815315Q14872Espacenet
KR 1020250010750 A2025-01-2115315Q14872Espacenet
JP 2024109657 A2024-08-1415154Q14872Espacenet
JP 2022551987 A2022-12-1427Q14872Espacenet
US 11446398 B22022-09-2050674Q14872Espacenet
JP 2022524081 A2022-04-27153645Q14872Espacenet
JP 2021536249 A2021-12-2715508Q14872Espacenet

1 to 10 of 21

See all 21 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants676

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMTF1 papersNewest fiscal year
R35GM118086Mechanistic studies of nucleic acid enzymes involved in DNA replication, transcription, and innate immunity62025
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity42025
R01ES010563Mechanisms of Manganese Neurotoxicity42025
R01AR077578Mechanisms of Cu-binding factors to promote myogenic gene expression32025
R35GM139644lluminating the biochemistry of zinc and RNA in live cells32025
P30ES010126UNC Center for Environmental Health and Susceptibility22025
P40OD010440Caenorhabditis Genetics Center22025
R01AI101171Host-mediated zinc sequestration during Acinetobacter baumannii infection22025
R01AR063759Defining the influence of RA genetic susceptibility factors on T cell antigen specificity and functional state22025
R01CA068682Biomedical Applications of Expanded Porphyrins22025

1 to 10 of 676Source NIH's project files

See all 676 nih grants

Papers1,378

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The KDM6 histone H3K27me3 demethylase inhibitor GSK-J4 induces metal and stress responses in multiple myeloma cells.RSC Chem Biol202642597942PubTator, text miningPubMed
Contrasting Effects of HT-2 Toxin Exposure and ZIP6 Knockdown on Chondrocyte Extracellular Matrix Metabolism.J Biochem Mol Toxicol202642533448PubTator, text miningPubMed
Identification of ITGB2, ELN, and KLRK1 as stress granule-related biomarkers of pterygium through integrated transcriptomic analysis and machine learning.Biochem Biophys Res Commun202642447550PubTator, text miningPubMed
Cuproptosis: A Potential Target for the Treatment of Systemic Lupus Erythematosus.J Inflamm Res202642445351PubTator, text miningPubMed
Analysis of end-stage renal disease mediated by cuproptosis-related genes.Clin Nephrol202642383521PubTator, text miningPubMed
Low Zinc Ameliorated the Decrease in Intestinal Copper Level Induced by Low Dietary Copper: Involvement of SUMOylated-Mtf-1 and Mtf-1/Atp7a Pathway.FASEB J202642257536PubTator, text miningPubMed
The PBAF chromatin remodeling complex contributes to metal homeostasis through MTF1 regulation.Metallomics202642246576PubTator, text miningPubMed
FDX1 as a predictive biomarker and therapeutic target for lymph node metastasis in gastric cancer.Clin Exp Med202642107026PubTator, text miningPubMed
Multifaceted Role of Copper Homeostasis in Gut Health: From Molecular Mechanisms to Therapeutic Interventions.Cells202641892335PubTator, text miningPubMed
Reactive oxygen species (ROS) in cancer: from mechanism to therapeutic implications.Signal Transduct Target Ther202641881983PubTator, text miningPubMed

1 to 10 of 1,378

See all 1,378 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4520

GET https://conductscience.org/api/genes/v1/4520/patents?page=2