Gene · 4522
MTHFD1: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MTHFD1: methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. Genes, record 4522. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4522
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P11586 | C-1-tetrahydrofolate synthase, cytoplasmic | 935 | 12 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 19701 | P11586 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 19701 | P11586 | Espacenet |
| JP 2025024198 A | 2025-02-19 | 13711 | P11586 | Espacenet |
| US 11694765 B2 | 2023-07-04 | 146 | P11586 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 50925 | P11586 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3405 | P11586 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 153896 | P11586 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 7062 | P11586 | Espacenet |
| JP 2020072653 A | 2020-05-14 | 287 | P11586 | Espacenet |
| US 10352947 B2 | 2019-07-16 | 178 | P11586 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,133
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MTHFD1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK056350 | Nutrition Obesity Research Center (NORC) | 18 | 2025 |
| ZIAHG000167 | The contribution folate and vitamin B12 genes to disease. | 13 | 2025 |
| P30CA072720 | Cancer Center Support Grant | 10 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 8 | 2025 |
| R01CA163591 | Tumor cell metabolism in action | 8 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 7 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 5 | 2025 |
| P30ES009089 | Center for Environmental Health in Northern Manhattan | 5 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 4 | 2025 |
| T32CA009531 | Training Program in the Biology of Cancer | 4 | 2025 |
1 to 10 of 1,133Source NIH's project files
See all 1,133 nih grantsPapers1,437
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A genome-wide CRISPR knockout screen identified host genes essential for Brucella invasion and intracellular survival. | Emerg Microbes Infect | 2026 | 42617139 | PubTator, text mining | PubMed |
| A prognostic signature based on methionine metabolism-related genes for cervical cancer: integrated transcriptomic and experimental validation. | PeerJ | 2026 | 42500207 | PubTator, text mining | PubMed |
| LncPTEC mediated homocysteine accumulation elevates oxidative stress via UBQLN1-dependent MTHFD1 ubiquitination in DKD. | Cell Death Dis | 2026 | 42414264 | PubTator, text mining | PubMed |
| A mathematical model of folate-mediated one-carbon metabolism in Down syndrome. | NPJ Syst Biol Appl | 2026 | 42362570 | PubTator, text mining | PubMed |
| Integrative Analysis of Genetic Risk Factors for Acute Myeloid Leukemia Using Mendelian Randomization and Single-Cell RNA Sequencing Validation. | Int J Genomics | 2026 | 42255490 | PubTator, text mining | PubMed |
Low folate status and related polymorphisms are associated with lower sperm quality in healthy males: The Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study. | Am J Clin Nutr | 2026 | 42250605 | PubTator, text mining | PubMed |
| Association of genetic polymorphisms on methotrexate toxicity in patients with rheumatoid arthritis. | Arch Med Sci | 2026 | 42110610 | PubTator, text mining | PubMed |
| Role of one-carbon metabolism variants in the associations between perfluoroalkyl substances exposure and birth size in the Taiwan Birth Panel Study. | Environ Epidemiol | 2026 | 41971740 | PubTator, text mining | PubMed |
| Protein arginine methyltransferases in cancer: mechanisms, functions, and therapeutic opportunities. | J Biomed Sci | 2026 | 41928257 | PubTator, text mining | PubMed |
| A 'Standard of Care PLUS' Model for Preterm Birth Prevention: Integrating Nutrient and Gene Variant Analysis with Targeted Interventions. | J Pers Med | 2026 | 41893003 | PubTator, text mining | PubMed |
1 to 10 of 1,437
See all 1,437 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4522
GET https://conductscience.org/api/genes/v1/4522/patents?page=2