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MTHFR: methylenetetrahydrofolate reductase

1 protein, 104 patents, 0 drugs, 0 trials, 3,892 NIH grants and 14,567 papers.

Gene 6

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolMTHFRHGNC
Namemethylenetetrahydrofolate reductaseHGNC
NCBI Gene ID4524NCBI Gene
HGNC IDHGNC:7436HGNC
EnsemblENSG00000177000NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P42898Methylenetetrahydrofolate reductase (NADPH)6564Ensembl, GeneID, HGNCUniProt

Patents 104

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21130P42898Espacenet
EP 4640849 A22025-10-291487P42898Espacenet
EP 4641201 A22025-10-2910057P42898Espacenet
JP 2025519096 A2025-06-241487P42898Espacenet
JP 2025517969 A2025-06-1210057P42898Espacenet
JP 2024123008 A2024-09-106977P42898Espacenet
JP 2024123008 A2024-09-106978P42898Espacenet
US 11708610 B22023-07-25871P42898Espacenet
JP 2023521663 A2023-05-25129P42898Espacenet
US 11446398 B22022-09-2050957P42898Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3892

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30ES010126UNC Center for Environmental Health and Susceptibility242,025NIH's project files
P42ES004705Toxic substances in the environment212,025NIH's project files
ZIAHG000167The contribution folate and vitamin B12 genes to disease.212,025NIH's project files
P30ES009089Center for Environmental Health in Northern Manhattan192,025NIH's project files
P30DK056350Nutrition Obesity Research Center (NORC)172,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)162,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology152,025NIH's project files
P30CA016672Cancer Center Support Grant142,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)142,025NIH's project files
P30DK063491Diabetes Research Center (DRC)122,025NIH's project files

Papers 14567

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42799590PubTator, text miningPubMed
42792745PubTator, text miningPubMed
42792438PubTator, text miningPubMed
42781488PubTator, text miningPubMed
42766070PubTator, text miningPubMed
42761979PubTator, text miningPubMed
42760941PubTator, text miningPubMed
42756288PubTator, text miningPubMed
42752660PubTator, text miningPubMed
42745328PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license