Gene · 4536
MT-ND2: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MT-ND2: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 2. Genes, record 4536. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4536
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P03891 | NADH-ubiquinone oxidoreductase chain 2 | 347 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 317 | P03891 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2731 | P03891 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2731 | P03891 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 317 | P03891 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 52332 | P03891 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 155303 | P03891 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1693 | P03891 | Espacenet |
| US 9073976 B2 | 2015-07-07 | 60 | P03891 | Espacenet |
| EP 2803733 A1 | 2014-11-19 | 3 | P03891 | Espacenet |
| US 8859500 B2 | 2014-10-14 | 9 | P03891 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants1,226
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MT-ND2 papers | Newest fiscal year |
|---|---|---|---|
| P30MH062512 | HIV Neurobehavioral Research Center | 7 | 2025 |
| P30AI036214 | San Diego Center for AIDS Research (SD CFAR) | 5 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| R25MH081482 | Interdisciplinary Research Fellowship in NeuroAIDS | 4 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 3 | 2025 |
| P30CA071789 | University of Hawaii Cancer Center CCSG | 3 | 2025 |
| P30CA168524 | The University of Kansas Cancer Center | 3 | 2025 |
| P30MH075673 | JHU Center for the Advancement of HIV Neurotherapeutics (JHU CAHN) | 3 | 2025 |
| R01CA159859 | Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma | 3 | 2025 |
1 to 10 of 1,226Source NIH's project files
See all 1,226 nih grantsPapers2,405
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The first two complete mitochondrial genomes for the genus Neotrichoporoides (Hymenoptera, Eulophidae) and their phylogenetic analysis. | Zookeys | 2026 | 42732344 | PubTator, text mining | PubMed |
| A new species of Heremites Gray, 1845 (Squamata, Scincidae) from the transboundary Hindu Kush foothills. | Zookeys | 2026 | 42732331 | PubTator, text mining | PubMed |
| Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma. | Cell Death Dis | 2026 | 42675041 | PubTator, text mining | PubMed |
| Phase-dependent dynamics of circulating cell-free mitochondrial DNA reflect distinct immunometabolic states. | Rev Inst Med Trop Sao Paulo | 2026 | 42525119 | PubTator, text mining | PubMed |
| Description of a New Species of Cyrtodactylus (Squamata: Gekkonidae) from Eastern Nepal. | Zootaxa | 2026 | 42408908 | PubTator, text mining | PubMed |
| A new species of Cyrtodactylus Gray, 1827 (Reptilia: Squamata: Gekkonidae) from Kokrajhar District, Assam, India. | Zootaxa | 2026 | 42408578 | PubTator, text mining | PubMed |
| Morphological and genetic evidence support new species of Stenocercus (Iguania: Tropiduridae) from the Peruvian Andes. | Zootaxa | 2026 | 42408508 | PubTator, text mining | PubMed |
| Confirmed occurrence and DNA barcoding of the Indo-Pacific Slender Gecko, Hemiphyllodactylus typus Bleeker, 1860 (Squamata, Gekkonidae) in Vietnam. | Zootaxa | 2026 | 42408452 | PubTator, text mining | PubMed |
| PCR-based species identification tools for wireworms (Coleoptera: Elateridae) of economic importance in Canada. | Pest Manag Sci | 2026 | 42348270 | PubTator, text mining | PubMed |
| Complete Mitochondrial Genome of Ovophis makazayazaya (Viperidae, Crotalinae) and Phylogenetic Analysis. | Ecol Evol | 2026 | 42256122 | PubTator, text mining | PubMed |
1 to 10 of 2,405
See all 2,405 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4536
GET https://conductscience.org/api/genes/v1/4536/patents