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Gene · 4537

MT-ND3: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MT-ND3: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3. Genes, record 4537. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4537

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Gene

Symbol
MT-ND3
HGNC
Name
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 3
HGNC
NCBI Gene ID
4537
NCBI Gene
HGNC ID
HGNC:7458
HGNC
Ensembl
ENSG00000198840
NCBI Gene
Aliases
MTND3, NAD3, ND3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P03897NADH-ubiquinone oxidoreductase chain 31155Ensembl, GeneID, HGNC

Source UniProt

Patents11

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19318P03897Espacenet
JP 2025529142 A2025-09-042732P03897Espacenet
US 12371689 B22025-07-292732P03897Espacenet
WO 2024214081 A12024-10-17318P03897Espacenet
US 11446398 B22022-09-2052333P03897Espacenet
JP 2022524081 A2022-04-27155304P03897Espacenet
JP 2017121240 A2017-07-1351906P03897Espacenet
JP 2015518704 A2015-07-0651906P03897Espacenet
EP 2803733 A12014-11-199P03897Espacenet
US 6489095 A2002-12-0320P03897Espacenet

1 to 10 of 11

See all 11 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants743

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMT-ND3 papersNewest fiscal year
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment32025
UL1TR001863Yale Clinical and Translational Science Award32025
K01AG078485Metabolic Vulnerability and Effects of APOE in Human Neurons with Impaired Endocytic Recycling22025
P30AG028740University of Florida Older Americans Independence Center (OAIC)22025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA008748Cancer Center Support Grant22025
P30CA015704Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30DK020593Vanderbilt Diabetes Research Center22025
P30ES010126UNC Center for Environmental Health and Susceptibility22025

1 to 10 of 743Source NIH's project files

See all 743 nih grants

Papers1,475

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The mitochondrial genome of Sapromyza sexpunctata (Diptera: Lauxaniidae) and its phylogenetic analysis.Mitochondrial DNA B Resour202642751292PubTator, text miningPubMed
One-time duplication and ongoing loss of mitochondrial tRNA genes in Cryptocercus cockroaches.Int J Biol Macromol202642702324PubTator, text miningPubMed
Genetic susceptibility to aminoglycoside cochleotoxicity in South African multidrug-resistant and rifampicin-resistant tuberculosis patients.S Afr J Commun Disord202642683731PubTator, text miningPubMed
Sodium arsenite inhibits ALKBH7 increasing tRNA m22G methylation in mitochondrial respiratory chain complex-flankng to drive malignant phenotype of bladder epithelial cells.Chem Biol Interact202642674266PubTator, text miningPubMed
Induction of differential cytotoxicity and ROS-driven severe genomic DNA damage and intrinsic mitochondrial apoptosis by erbium oxide nanoparticles in p53-compromised human NSCLC cells.Naunyn Schmiedebergs Arch Pharmacol202642489717PubTator, text miningPubMed
A large-scale multi-ancestry mitochondrial variant association analysis for cardiometabolic traits.Nat Commun202642401575PubTator, text miningPubMed
PCR-based species identification tools for wireworms (Coleoptera: Elateridae) of economic importance in Canada.Pest Manag Sci202642348270PubTator, text miningPubMed
MTA-NPs induce preferential cytotoxicity, oxidative DNA damage, and mitochondrial apoptosis in human Hep-G2 hepatocellular carcinoma cells.Naunyn Schmiedebergs Arch Pharmacol202642324372PubTator, text miningPubMed
Complete Mitochondrial Genome of Ovophis makazayazaya (Viperidae, Crotalinae) and Phylogenetic Analysis.Ecol Evol202642256122PubTator, text miningPubMed
Calcium hydroxide nanoparticles-induced oxidative stress and mitochondrial impairment drive genomic instability and programmed cell death in colorectal cancer cells.Naunyn Schmiedebergs Arch Pharmacol202642240662PubTator, text miningPubMed

1 to 10 of 1,475

See all 1,475 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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