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Gene · 4538

MT-ND4: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MT-ND4: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4. Genes, record 4538. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4538

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Gene

Symbol
MT-ND4
HGNC
Name
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
HGNC
NCBI Gene ID
4538
NCBI Gene
HGNC ID
HGNC:7459
HGNC
Ensembl
ENSG00000198886
NCBI Gene
Aliases
LHON, MTND4, NAD4, ND4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins2

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
C0HME5Mitochondrial alternative ND4 protein990HGNCUniProt
P03905NADH-ubiquinone oxidoreductase chain 44597Ensembl, GeneID, HGNCUniProt

Patents51

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19320P03905Espacenet
EP 4667578 A22025-12-2497P03905Espacenet
EP 4641202 A22025-10-29435P03905Espacenet
JP 2025131621 A2025-09-0997P03905Espacenet
JP 2025529142 A2025-09-042733P03905Espacenet
US 12371689 B22025-07-292733P03905Espacenet
JP 2025032204 A2025-03-1131815P03905Espacenet
KR 1020250017231 A2025-02-04435P03905Espacenet
EP 4461818 A22024-11-1331815P03905Espacenet
WO 2024214081 A12024-10-17320P03905Espacenet

1 to 10 of 51

See all 51 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,051

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMT-ND4 papersNewest fiscal year
P30EY014801Miami Center for Vision Research192025
P30EY006360P30-Core Grant for Vision Research112025
P30CA013696Cancer Center Support Grant82025
R01EY010804Setting the Stage for Replacement of Mitochondrial Genes62025
P30CA008748Cancer Center Support Grant52025
R01EY018213Defining Barriers to Gene Therapy42025
R01EY024698Gene Editing and Silencing in Phototransduction42025
RM1HG009490Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease42025
P30AG028740University of Florida Older Americans Independence Center (OAIC)32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,051Source NIH's project files

See all 1,051 nih grants

Papers2,585

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic diversity of nine necrophagous Sarcophagidae (Diptera) species in Portugal.J Forensic Leg Med202642748528PubTator, text miningPubMed
The first two complete mitochondrial genomes for the genus Neotrichoporoides (Hymenoptera, Eulophidae) and their phylogenetic analysis.Zookeys202642732344PubTator, text miningPubMed
Severe adverse events associated with general anesthesia with halogenated agents in patients of Venezuelan ancestry. Recommendations for clinical practice.Rev Esp Anestesiol Reanim (Engl Ed)202642685863PubTator, text miningPubMed
An adult case of acute encephalopathy associated with general anaesthesia and the m.11232T>C MT-ND4 variant.Rev Esp Anestesiol Reanim (Engl Ed)202642685860PubTator, text miningPubMed
"Tissue-specific mitochondrial dysfunction in keratoconus: An integrated structural, genomic, and functional analysis".Ocul Surf202642679894PubTator, text miningPubMed
Genetic architecture and inheritance patterns of Leber hereditary optic neuropathy among 419 Chinese pedigrees carrying the ND4 11778G>A mutation.J Genet Genomics202642632451PubTator, text miningPubMed
Gene therapy clinical trials for inherited eye diseases: The pediatric perspective.Eur J Ophthalmol202642627399PubTator, text miningPubMed
[Leber's hereditary optic nerve atrophy].Vestn Oftalmol202642608929PubTator, text miningPubMed
Systematic review of Leber's hereditary optic neuropathy - Clinical diagnosis, genetics overview and current concepts of treatment.Indian J Ophthalmol202642535808PubTator, text miningPubMed
Mitochondrial DNA digital PCR improves metastasis quantification in the chick chorioallantoic membrane (CAM) assay.Anal Biochem202642532311PubTator, text miningPubMed

1 to 10 of 2,585

See all 2,585 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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