Gene · 4538
MT-ND4: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MT-ND4: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4. Genes, record 4538. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4538
On this page
Gene
Proteins2
Reviewed human proteins whose Swiss-Prot entry states the gene.
Patents51
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 320 | P03905 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 97 | P03905 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 435 | P03905 | Espacenet |
| JP 2025131621 A | 2025-09-09 | 97 | P03905 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2733 | P03905 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2733 | P03905 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 31815 | P03905 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 435 | P03905 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 31815 | P03905 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 320 | P03905 | Espacenet |
1 to 10 of 51
See all 51 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants1,051
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MT-ND4 papers | Newest fiscal year |
|---|---|---|---|
| P30EY014801 | Miami Center for Vision Research | 19 | 2025 |
| P30EY006360 | P30-Core Grant for Vision Research | 11 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 8 | 2025 |
| R01EY010804 | Setting the Stage for Replacement of Mitochondrial Genes | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| R01EY018213 | Defining Barriers to Gene Therapy | 4 | 2025 |
| R01EY024698 | Gene Editing and Silencing in Phototransduction | 4 | 2025 |
| RM1HG009490 | Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease | 4 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,051Source NIH's project files
See all 1,051 nih grantsPapers2,585
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetic diversity of nine necrophagous Sarcophagidae (Diptera) species in Portugal. | J Forensic Leg Med | 2026 | 42748528 | PubTator, text mining | PubMed |
| The first two complete mitochondrial genomes for the genus Neotrichoporoides (Hymenoptera, Eulophidae) and their phylogenetic analysis. | Zookeys | 2026 | 42732344 | PubTator, text mining | PubMed |
| Severe adverse events associated with general anesthesia with halogenated agents in patients of Venezuelan ancestry. Recommendations for clinical practice. | Rev Esp Anestesiol Reanim (Engl Ed) | 2026 | 42685863 | PubTator, text mining | PubMed |
| An adult case of acute encephalopathy associated with general anaesthesia and the m.11232T>C MT-ND4 variant. | Rev Esp Anestesiol Reanim (Engl Ed) | 2026 | 42685860 | PubTator, text mining | PubMed |
| "Tissue-specific mitochondrial dysfunction in keratoconus: An integrated structural, genomic, and functional analysis". | Ocul Surf | 2026 | 42679894 | PubTator, text mining | PubMed |
| Genetic architecture and inheritance patterns of Leber hereditary optic neuropathy among 419 Chinese pedigrees carrying the ND4 11778G>A mutation. | J Genet Genomics | 2026 | 42632451 | PubTator, text mining | PubMed |
| Gene therapy clinical trials for inherited eye diseases: The pediatric perspective. | Eur J Ophthalmol | 2026 | 42627399 | PubTator, text mining | PubMed |
| [Leber's hereditary optic nerve atrophy]. | Vestn Oftalmol | 2026 | 42608929 | PubTator, text mining | PubMed |
| Systematic review of Leber's hereditary optic neuropathy - Clinical diagnosis, genetics overview and current concepts of treatment. | Indian J Ophthalmol | 2026 | 42535808 | PubTator, text mining | PubMed |
| Mitochondrial DNA digital PCR improves metastasis quantification in the chick chorioallantoic membrane (CAM) assay. | Anal Biochem | 2026 | 42532311 | PubTator, text mining | PubMed |
1 to 10 of 2,585
See all 2,585 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4538
GET https://conductscience.org/api/genes/v1/4538/patents?page=2