Gene · 4539
MT-ND4L: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MT-ND4L: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L. Genes, record 4539. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4539
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P03901 | NADH-ubiquinone oxidoreductase chain 4L | 98 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 319 | P03901 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7931 | P03901 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2734 | P03901 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2734 | P03901 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7931 | P03901 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 319 | P03901 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 52335 | P03901 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 155306 | P03901 | Espacenet |
| JP 2022511502 A | 2022-01-31 | 55 | P03901 | Espacenet |
| KR 1020210100656 A | 2021-08-17 | 24 | P03901 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants525
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MT-ND4L papers | Newest fiscal year |
|---|---|---|---|
| ZIAHL006001 | Framingham Project/Levy | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 2 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 2 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 2 | 2025 |
| R01NS092558 | Mitochondrial ROS Microdomains and Neuronal Ischemia | 2 | 2025 |
| R01NS115906 | Mitochondrial Energy Sensing and Neuronal Function | 2 | 2025 |
| T32ES018827 | Research Training in Environmental Toxicology | 2 | 2025 |
| F31CA284719 | Investigating the role of apoptosis-resistance and the tumor environment on development and maintenance of sacrococcygeal teratomas | 1 | 2025 |
| I01BX004845 | Genome engineering of stem cells for kidney regeneration. | 1 | 2025 |
| I01BX005015 | SDR: Genomic analysis of blast tube induced TBI in mice | 1 | 2025 |
1 to 10 of 525Source NIH's project files
See all 525 nih grantsPapers994
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Overexpression of TCF7L2 promotes the viability and migration of MHCC-97H human hepatocellular carcinoma cells by upregulating MT-ND4L. | Transl Cancer Res | 2026 | 42724469 | PubTator, text mining | PubMed |
| Rapid identification of dried suckling deer using molecular authentication-based PCR-GICA and PCR-FQICA. | Anal Biochem | 2026 | 42537734 | PubTator, text mining | PubMed |
| Characterization of the complete mitogenomes of two phytophagous scarab beetles (Coleoptera: Scarabaeidae) and their phylogenetic implications. | Mitochondrial DNA A DNA Mapp Seq Anal | 2026 | 42246426 | PubTator, text mining | PubMed |
| Complex correlations between mitochondrial DNA variants and gut microbiome in major depressive disorder: a genome-wide association analysis. | BMC Psychiatry | 2026 | 42163161 | PubTator, text mining | PubMed |
| Hydration-Controlled Proton Transport in Respiratory Complex I. | J Am Chem Soc | 2026 | 41889323 | PubTator, text mining | PubMed |
| Resistance-based exercise restores muscle health in dialysis patients. | J Muscle Res Cell Motil | 2026 | 41831133 | PubTator, text mining | PubMed |
| Mitochondrial Gene Expression as a Novel Biomarker for Detecting and Discriminating Neurotoxic Pesticide Exposure in Ramulus phyllodeus (Chen & He, 2008). | Insects | 2026 | 41752623 | PubTator, text mining | PubMed |
| Multi-System Genetic Architecture of Hypermobile Ehlers-Danlos Syndrome: Integrating Machine Learning with Subject-Level Genomic Analysis. | Genes (Basel) | 2026 | 41751595 | PubTator, text mining | PubMed |
| mRNA Sequencing of Limbal Epithelial Cells and mRNA/miRNA Profiling of Limbal Stromal Cells in PAX6-Related Congenital Aniridia. | Cells | 2026 | 41744783 | PubTator, text mining | PubMed |
| Unraveling the molecular mechanisms in severe Alzheimer's disease based on transcriptomic data using next generation knowledge discovery methods. | Pak J Med Sci | 2026 | 41737170 | PubTator, text mining | PubMed |
1 to 10 of 994
See all 994 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4539
GET https://conductscience.org/api/genes/v1/4539/patents