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Gene · 4539

MT-ND4L: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MT-ND4L: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L. Genes, record 4539. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4539

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Gene

Symbol
MT-ND4L
HGNC
Name
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L
HGNC
NCBI Gene ID
4539
NCBI Gene
HGNC ID
HGNC:7460
HGNC
Ensembl
ENSG00000212907
NCBI Gene
Aliases
MTND4L, NAD4L, ND4L
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P03901NADH-ubiquinone oxidoreductase chain 4L985Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19319P03901Espacenet
EP 4650780 A22025-11-197931P03901Espacenet
JP 2025529142 A2025-09-042734P03901Espacenet
US 12371689 B22025-07-292734P03901Espacenet
JP 2025517970 A2025-06-127931P03901Espacenet
WO 2024214081 A12024-10-17319P03901Espacenet
US 11446398 B22022-09-2052335P03901Espacenet
JP 2022524081 A2022-04-27155306P03901Espacenet
JP 2022511502 A2022-01-3155P03901Espacenet
KR 1020210100656 A2021-08-1724P03901Espacenet

1 to 10 of 16

See all 16 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants525

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMT-ND4L papersNewest fiscal year
ZIAHL006001Framingham Project/Levy32025
P30CA008748Cancer Center Support Grant22025
P30CA068485Cancer Center Support Grant22025
P30EY008126Core Grant in Vision Research22025
R01NS092558Mitochondrial ROS Microdomains and Neuronal Ischemia22025
R01NS115906Mitochondrial Energy Sensing and Neuronal Function22025
T32ES018827Research Training in Environmental Toxicology22025
F31CA284719Investigating the role of apoptosis-resistance and the tumor environment on development and maintenance of sacrococcygeal teratomas12025
I01BX004845Genome engineering of stem cells for kidney regeneration.12025
I01BX005015SDR: Genomic analysis of blast tube induced TBI in mice12025

1 to 10 of 525Source NIH's project files

See all 525 nih grants

Papers994

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Overexpression of TCF7L2 promotes the viability and migration of MHCC-97H human hepatocellular carcinoma cells by upregulating MT-ND4L.Transl Cancer Res202642724469PubTator, text miningPubMed
Rapid identification of dried suckling deer using molecular authentication-based PCR-GICA and PCR-FQICA.Anal Biochem202642537734PubTator, text miningPubMed
Characterization of the complete mitogenomes of two phytophagous scarab beetles (Coleoptera: Scarabaeidae) and their phylogenetic implications.Mitochondrial DNA A DNA Mapp Seq Anal202642246426PubTator, text miningPubMed
Complex correlations between mitochondrial DNA variants and gut microbiome in major depressive disorder: a genome-wide association analysis.BMC Psychiatry202642163161PubTator, text miningPubMed
Hydration-Controlled Proton Transport in Respiratory Complex I.J Am Chem Soc202641889323PubTator, text miningPubMed
Resistance-based exercise restores muscle health in dialysis patients.J Muscle Res Cell Motil202641831133PubTator, text miningPubMed
Mitochondrial Gene Expression as a Novel Biomarker for Detecting and Discriminating Neurotoxic Pesticide Exposure in Ramulus phyllodeus (Chen & He, 2008).Insects202641752623PubTator, text miningPubMed
Multi-System Genetic Architecture of Hypermobile Ehlers-Danlos Syndrome: Integrating Machine Learning with Subject-Level Genomic Analysis.Genes (Basel)202641751595PubTator, text miningPubMed
mRNA Sequencing of Limbal Epithelial Cells and mRNA/miRNA Profiling of Limbal Stromal Cells in PAX6-Related Congenital Aniridia.Cells202641744783PubTator, text miningPubMed
Unraveling the molecular mechanisms in severe Alzheimer's disease based on transcriptomic data using next generation knowledge discovery methods.Pak J Med Sci202641737170PubTator, text miningPubMed

1 to 10 of 994

See all 994 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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