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Gene · 4540

MT-ND5: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MT-ND5: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5. Genes, record 4540. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4540

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Gene

Symbol
MT-ND5
HGNC
Name
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
HGNC
NCBI Gene ID
4540
NCBI Gene
HGNC ID
HGNC:7461
HGNC
Ensembl
ENSG00000198786
NCBI Gene
Aliases
MTND5, NAD5, ND5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P03915NADH-ubiquinone oxidoreductase chain 56037Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19321P03915Espacenet
EP 4650780 A22025-11-197947P03915Espacenet
EP 4641202 A22025-10-29434P03915Espacenet
JP 2025529142 A2025-09-042735P03915Espacenet
US 12371689 B22025-07-292735P03915Espacenet
JP 2025517970 A2025-06-127947P03915Espacenet
KR 1020250017231 A2025-02-04434P03915Espacenet
WO 2024214081 A12024-10-17321P03915Espacenet
US 11446398 B22022-09-2052336P03915Espacenet
JP 2022524081 A2022-04-27155307P03915Espacenet

1 to 10 of 16

See all 16 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,160

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMT-ND5 papersNewest fiscal year
P30CA008748Cancer Center Support Grant82025
P30AG028740University of Florida Older Americans Independence Center (OAIC)72025
R01EY010804Setting the Stage for Replacement of Mitochondrial Genes72025
P30CA016672Cancer Center Support Grant62025
RM1HG008935Center for dynamic RNA epitranscriptomes - Renewal62025
RM1HG009490Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease42025
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer42025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 532025
P30CA015704Cancer Center Support Grant32025
P30CA168524The University of Kansas Cancer Center32025

1 to 10 of 1,160Source NIH's project files

See all 1,160 nih grants

Papers2,452

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mitochondrial Genomic Alterations in Pediatric Acute Lymphoblastic Leukemia: Implications for Methotrexate-Induced Neurotoxicity and Ethnic Disparities.Cancer Med202642779111PubTator, text miningPubMed
[Acute anterior ischemic optic neuropathy in the context of mitochondrial disease].Rev Med Liege202642751844PubTator, text miningPubMed
Pharmacological modulation of GLI signaling promotes human iPSC-derived cardiomyocyte maturation via PGC1α-associated mitochondrial programs.J Mol Cell Cardiol202642716425PubTator, text miningPubMed
One-time duplication and ongoing loss of mitochondrial tRNA genes in Cryptocercus cockroaches.Int J Biol Macromol202642702324PubTator, text miningPubMed
"Tissue-specific mitochondrial dysfunction in keratoconus: An integrated structural, genomic, and functional analysis".Ocul Surf202642679894PubTator, text miningPubMed
Interim analysis of an international multi-site prospective natural history study evaluating the clinical presentation and progression of Leigh syndrome spectrum disorders.Ther Adv Rare Dis202642662191PubTator, text miningPubMed
Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease.medRxiv202642620183PubTator, text miningPubMed
Disease-mutations perturb proton transfer reactions in respiratory complex I.Biochim Biophys Acta Bioenerg202642607826PubTator, text miningPubMed
Insights into adaptive evolution in different locomotor modes and phylogeny of Sciuridae from mitogenomes of flying and tree squirrels.PLoS One202642599909PubTator, text miningPubMed
Expression and mutation characteristics of mitochondrial genes in PBMCs of SLE patients: Implications for SLE pathogenesis.Medicine (Baltimore)202642470042PubTator, text miningPubMed

1 to 10 of 2,452

See all 2,452 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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