Gene · 4540
MT-ND5: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MT-ND5: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 5. Genes, record 4540. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4540
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P03915 | NADH-ubiquinone oxidoreductase chain 5 | 603 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents16
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 321 | P03915 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7947 | P03915 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 434 | P03915 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2735 | P03915 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2735 | P03915 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7947 | P03915 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 434 | P03915 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 321 | P03915 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 52336 | P03915 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 155307 | P03915 | Espacenet |
1 to 10 of 16
See all 16 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants1,160
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MT-ND5 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 7 | 2025 |
| R01EY010804 | Setting the Stage for Replacement of Mitochondrial Genes | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| RM1HG008935 | Center for dynamic RNA epitranscriptomes - Renewal | 6 | 2025 |
| RM1HG009490 | Center for Genomic Editing and Recording: Development and Application of Next-Generation Genome and Epigenome Editing Methods to Advance the Study and Treatment of Human Disease | 4 | 2025 |
| ZIABC011028 | Clinical Studies of the Molecular Genetic Basis of Kidney Cancer | 4 | 2025 |
| P20GM103418 | Kansas IDeA Network of Biomedical Research Excellence 5 | 3 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 3 | 2025 |
| P30CA168524 | The University of Kansas Cancer Center | 3 | 2025 |
1 to 10 of 1,160Source NIH's project files
See all 1,160 nih grantsPapers2,452
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mitochondrial Genomic Alterations in Pediatric Acute Lymphoblastic Leukemia: Implications for Methotrexate-Induced Neurotoxicity and Ethnic Disparities. | Cancer Med | 2026 | 42779111 | PubTator, text mining | PubMed |
| [Acute anterior ischemic optic neuropathy in the context of mitochondrial disease]. | Rev Med Liege | 2026 | 42751844 | PubTator, text mining | PubMed |
| Pharmacological modulation of GLI signaling promotes human iPSC-derived cardiomyocyte maturation via PGC1α-associated mitochondrial programs. | J Mol Cell Cardiol | 2026 | 42716425 | PubTator, text mining | PubMed |
| One-time duplication and ongoing loss of mitochondrial tRNA genes in Cryptocercus cockroaches. | Int J Biol Macromol | 2026 | 42702324 | PubTator, text mining | PubMed |
| "Tissue-specific mitochondrial dysfunction in keratoconus: An integrated structural, genomic, and functional analysis". | Ocul Surf | 2026 | 42679894 | PubTator, text mining | PubMed |
| Interim analysis of an international multi-site prospective natural history study evaluating the clinical presentation and progression of Leigh syndrome spectrum disorders. | Ther Adv Rare Dis | 2026 | 42662191 | PubTator, text mining | PubMed |
| Recurrent Single-Nucleotide Insertions in the Mitochondrial Second Light-Strand Promoter Cause Tubulointerstitial Kidney Disease. | medRxiv | 2026 | 42620183 | PubTator, text mining | PubMed |
| Disease-mutations perturb proton transfer reactions in respiratory complex I. | Biochim Biophys Acta Bioenerg | 2026 | 42607826 | PubTator, text mining | PubMed |
| Insights into adaptive evolution in different locomotor modes and phylogeny of Sciuridae from mitogenomes of flying and tree squirrels. | PLoS One | 2026 | 42599909 | PubTator, text mining | PubMed |
| Expression and mutation characteristics of mitochondrial genes in PBMCs of SLE patients: Implications for SLE pathogenesis. | Medicine (Baltimore) | 2026 | 42470042 | PubTator, text mining | PubMed |
1 to 10 of 2,452
See all 2,452 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4540
GET https://conductscience.org/api/genes/v1/4540/patents