Gene · 4541
MT-ND6: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MT-ND6: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6. Genes, record 4541. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4541
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P03923 | NADH-ubiquinone oxidoreductase chain 6 | 174 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 322 | P03923 | Espacenet |
| EP 4667578 A2 | 2025-12-24 | 98 | P03923 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 7915 | P03923 | Espacenet |
| JP 2025131621 A | 2025-09-09 | 98 | P03923 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2736 | P03923 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2736 | P03923 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 7915 | P03923 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 322 | P03923 | Espacenet |
| JP 2024529033 A | 2024-08-01 | 161 | P03923 | Espacenet |
| EP 4382601 A1 | 2024-06-12 | 161 | P03923 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants941
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MT-ND6 papers | Newest fiscal year |
|---|---|---|---|
| P30EY014801 | Miami Center for Vision Research | 9 | 2025 |
| P30EY006360 | P30-Core Grant for Vision Research | 8 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 4 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 4 | 2025 |
| R01EY010804 | Setting the Stage for Replacement of Mitochondrial Genes | 4 | 2025 |
| P20GM103418 | Kansas IDeA Network of Biomedical Research Excellence 5 | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30DK056336 | UAB Nutrition Obesity Research Center (NORC) | 3 | 2025 |
| P30DK079626 | UAB Diabetes Research Center | 3 | 2025 |
| R01EY018213 | Defining Barriers to Gene Therapy | 3 | 2025 |
1 to 10 of 941Source NIH's project files
See all 941 nih grantsPapers2,261
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Polymer-specific nanoplastics trigger oxidative stress, inflammatory activation, and mitoepigenetic remodeling: in vitro and in silico evidence for MT-ND6-mediated mitochondrial complex I perturbation. | Front Toxicol | 2026 | 42733707 | PubTator, text mining | PubMed |
| Allotopic expression of ND6 restores vision in a mitochondrial disease model. | JCI Insight | 2026 | 42709484 | PubTator, text mining | PubMed |
| Concordant mtDNA heteroplasmy between trophectoderm and inner cell mass supports blastocyst-stage PGT-mt for m.14487T>C. | J Assist Reprod Genet | 2026 | 42649365 | PubTator, text mining | PubMed |
| Genetic architecture and inheritance patterns of Leber hereditary optic neuropathy among 419 Chinese pedigrees carrying the ND4 11778G>A mutation. | J Genet Genomics | 2026 | 42632451 | PubTator, text mining | PubMed |
| Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery. | Invest Ophthalmol Vis Sci | 2026 | 42390170 | PubTator, text mining | PubMed |
| Histidine metabolic reprogramming drives oxidative stress induced mtDNA release to promote necroptosis and airway inflammation in severe asthma. | Redox Biol | 2026 | 42372708 | PubTator, text mining | PubMed |
| The complete mitochondrial genome of the Boulenophrys xianjuensis (Anura: Megophryidae). | Mitochondrial DNA B Resour | 2026 | 42370214 | PubTator, text mining | PubMed |
| PCR-based species identification tools for wireworms (Coleoptera: Elateridae) of economic importance in Canada. | Pest Manag Sci | 2026 | 42348270 | PubTator, text mining | PubMed |
| The m.14484T>C MT-ND6 Mutation Presenting with a Hereditary Spastic-Paraparesis Phenotype. | Mov Disord Clin Pract | 2026 | 42236298 | PubTator, text mining | PubMed |
| Chloroplast and Mitochondrial Genomes of the Lichen-Symbiotic Green Alga Trebouxia Illuminate Evolutionary Relationships and Climate Associations and Yield New Phylogenetic Markers. | Genome Biol Evol | 2026 | 42216275 | PubTator, text mining | PubMed |
1 to 10 of 2,261
See all 2,261 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4541
GET https://conductscience.org/api/genes/v1/4541/patents?page=2