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Gene · 4541

MT-ND6: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MT-ND6: mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6. Genes, record 4541. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4541

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Gene

Symbol
MT-ND6
HGNC
Name
mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 6
HGNC
NCBI Gene ID
4541
NCBI Gene
HGNC ID
HGNC:7462
HGNC
Ensembl
ENSG00000198695
NCBI Gene
Aliases
MTND6, NAD6, ND6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P03923NADH-ubiquinone oxidoreductase chain 61745Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19322P03923Espacenet
EP 4667578 A22025-12-2498P03923Espacenet
EP 4650780 A22025-11-197915P03923Espacenet
JP 2025131621 A2025-09-0998P03923Espacenet
JP 2025529142 A2025-09-042736P03923Espacenet
US 12371689 B22025-07-292736P03923Espacenet
JP 2025517970 A2025-06-127915P03923Espacenet
WO 2024214081 A12024-10-17322P03923Espacenet
JP 2024529033 A2024-08-01161P03923Espacenet
EP 4382601 A12024-06-12161P03923Espacenet

1 to 10 of 33

See all 33 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants941

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMT-ND6 papersNewest fiscal year
P30EY014801Miami Center for Vision Research92025
P30EY006360P30-Core Grant for Vision Research82025
P30AG028740University of Florida Older Americans Independence Center (OAIC)42025
P30CA013696Cancer Center Support Grant42025
R01EY010804Setting the Stage for Replacement of Mitochondrial Genes42025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 532025
P30CA008748Cancer Center Support Grant32025
P30DK056336UAB Nutrition Obesity Research Center (NORC)32025
P30DK079626UAB Diabetes Research Center32025
R01EY018213Defining Barriers to Gene Therapy32025

1 to 10 of 941Source NIH's project files

See all 941 nih grants

Papers2,261

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Polymer-specific nanoplastics trigger oxidative stress, inflammatory activation, and mitoepigenetic remodeling: in vitro and in silico evidence for MT-ND6-mediated mitochondrial complex I perturbation.
Front Toxicol202642733707PubTator, text miningPubMed
Allotopic expression of ND6 restores vision in a mitochondrial disease model.JCI Insight202642709484PubTator, text miningPubMed
Concordant mtDNA heteroplasmy between trophectoderm and inner cell mass supports blastocyst-stage PGT-mt for m.14487T>C.J Assist Reprod Genet202642649365PubTator, text miningPubMed
Genetic architecture and inheritance patterns of Leber hereditary optic neuropathy among 419 Chinese pedigrees carrying the ND4 11778G>A mutation.J Genet Genomics202642632451PubTator, text miningPubMed
Archetypal Visual Field Analysis of Patients With Chronic Leber Hereditary Optic Neuropathy in Relation to Visual Recovery.Invest Ophthalmol Vis Sci202642390170PubTator, text miningPubMed
Histidine metabolic reprogramming drives oxidative stress induced mtDNA release to promote necroptosis and airway inflammation in severe asthma.Redox Biol202642372708PubTator, text miningPubMed
The complete mitochondrial genome of the Boulenophrys xianjuensis (Anura: Megophryidae).Mitochondrial DNA B Resour202642370214PubTator, text miningPubMed
PCR-based species identification tools for wireworms (Coleoptera: Elateridae) of economic importance in Canada.Pest Manag Sci202642348270PubTator, text miningPubMed
The m.14484T>C MT-ND6 Mutation Presenting with a Hereditary Spastic-Paraparesis Phenotype.Mov Disord Clin Pract202642236298PubTator, text miningPubMed
Chloroplast and Mitochondrial Genomes of the Lichen-Symbiotic Green Alga Trebouxia Illuminate Evolutionary Relationships and Climate Associations and Yield New Phylogenetic Markers.Genome Biol Evol202642216275PubTator, text miningPubMed

1 to 10 of 2,261

See all 2,261 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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