Gene · 4548
MTR: 5-methyltetrahydrofolate-homocysteine methyltransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MTR: 5-methyltetrahydrofolate-homocysteine methyltransferase. Genes, record 4548. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4548
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99707 | Methionine synthase | 1,265 | 9 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 131 | Q99707 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 35795 | Q99707 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8077 | Q99707 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8213 | Q99707 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8213 | Q99707 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8077 | Q99707 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 439 | Q99707 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 130 | Q99707 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 439 | Q99707 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 103410 | Q99707 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,346
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MTR papers | Newest fiscal year |
|---|---|---|---|
| R01DK045776 | B12 Trafficking and Inherited Defects | 38 | 2025 |
| P42ES004705 | Toxic substances in the environment | 11 | 2025 |
| P30ES009089 | Center for Environmental Health in Northern Manhattan | 10 | 2025 |
| ZIAHG000167 | The contribution folate and vitamin B12 genes to disease. | 10 | 2025 |
| ZIAHG200318 | Investigations of Methylmalonic Acidemia and Related Disorders | 10 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 9 | 2025 |
| P30DK056350 | Nutrition Obesity Research Center (NORC) | 7 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 7 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 5 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 5 | 2025 |
1 to 10 of 1,346Source NIH's project files
See all 1,346 nih grantsPapers3,187
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity. | Proc Natl Acad Sci U S A | 2026 | 42709793 | PubTator, text mining | PubMed |
| Recovery of a minor cryo-EM particle population reveals conformational equilibria linking cofactor loading, turnover, and reactivation in methionine synthase. | bioRxiv | 2026 | 42619950 | PubTator, text mining | PubMed |
| Methionine restriction plus vitamin B12 antagonism overcomes methionine independence for cancer therapy. | Cancer Lett | 2026 | 42425191 | PubTator, text mining | PubMed |
| Molecular and toxicogenetic safety profile of short-term nitrous oxide anesthesia in surgical patients. | Mol Biol Rep | 2026 | 42384267 | PubTator, text mining | PubMed |
| The impact of vitamin B12 deficiency on urinary profile of de novo purine synthesis intermediates: consequences of the methylfolate trap. | Nucleosides Nucleotides Nucleic Acids | 2026 | 42343592 | PubTator, text mining | PubMed |
| Methionine Synthase Interacts With the Methionine Adenosyl-Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus. | J Inherit Metab Dis | 2026 | 42309558 | PubTator, text mining | PubMed |
| Nitrous oxide abuse prevalence, mechanisms, treatments and prevention. | Curr Med Res Opin | 2026 | 42149724 | PubTator, text mining | PubMed |
| Structural insights into cobalamin loading and reactivation of human methionine synthase. | Nat Commun | 2026 | 42115646 | PubTator, text mining | PubMed |
| Arterial and Venous Thrombotic Complications Following Recreational Nitrous Oxide Misuse: A Comprehensive Review. | Ann Vasc Surg | 2026 | 42067022 | PubTator, text mining | PubMed |
| Unmasking Hypercoagulability: Superior Sagittal Sinus Thrombosis Attributed to Pernicious Anemia in a Patient With Normal Hemoglobin Levels. | Am J Case Rep | 2026 | 41915627 | PubTator, text mining | PubMed |
1 to 10 of 3,187
See all 3,187 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4548
GET https://conductscience.org/api/genes/v1/4548/patents?page=2