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Gene · 4548

MTR: 5-methyltetrahydrofolate-homocysteine methyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MTR: 5-methyltetrahydrofolate-homocysteine methyltransferase. Genes, record 4548. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4548

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Gene

Symbol
MTR
HGNC
Name
5-methyltetrahydrofolate-homocysteine methyltransferase
HGNC
NCBI Gene ID
4548
NCBI Gene
HGNC ID
HGNC:7468
HGNC
Ensembl
ENSG00000116984
NCBI Gene
Aliases
HMAG, MS, cblG
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99707Methionine synthase1,2659Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21131Q99707Espacenet
JP 2026004568 A2026-01-1435795Q99707Espacenet
EP 4650780 A22025-11-198077Q99707Espacenet
EP 4641201 A22025-10-298213Q99707Espacenet
JP 2025517969 A2025-06-128213Q99707Espacenet
JP 2025517970 A2025-06-128077Q99707Espacenet
JP 2025062604 A2025-04-14439Q99707Espacenet
JP 2023521663 A2023-05-25130Q99707Espacenet
US 11446398 B22022-09-20439Q99707Espacenet
JP 2022524081 A2022-04-27103410Q99707Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,346

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMTR papersNewest fiscal year
R01DK045776B12 Trafficking and Inherited Defects382025
P42ES004705Toxic substances in the environment112025
P30ES009089Center for Environmental Health in Northern Manhattan102025
ZIAHG000167The contribution folate and vitamin B12 genes to disease.102025
ZIAHG200318Investigations of Methylmalonic Acidemia and Related Disorders102025
P30ES010126UNC Center for Environmental Health and Susceptibility92025
P30DK056350Nutrition Obesity Research Center (NORC)72025
P30ES013508Center of Excellence in Environmental Toxicology72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures52025

1 to 10 of 1,346Source NIH's project files

See all 1,346 nih grants

Papers3,187

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity.Proc Natl Acad Sci U S A202642709793PubTator, text miningPubMed
Recovery of a minor cryo-EM particle population reveals conformational equilibria linking cofactor loading, turnover, and reactivation in methionine synthase.bioRxiv202642619950PubTator, text miningPubMed
Methionine restriction plus vitamin B12 antagonism overcomes methionine independence for cancer therapy.Cancer Lett202642425191PubTator, text miningPubMed
Molecular and toxicogenetic safety profile of short-term nitrous oxide anesthesia in surgical patients.Mol Biol Rep202642384267PubTator, text miningPubMed
The impact of vitamin B12 deficiency on urinary profile of de novo purine synthesis intermediates: consequences of the methylfolate trap.Nucleosides Nucleotides Nucleic Acids202642343592PubTator, text miningPubMed
Methionine Synthase Interacts With the Methionine Adenosyl-Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus.J Inherit Metab Dis202642309558PubTator, text miningPubMed
Nitrous oxide abuse prevalence, mechanisms, treatments and prevention.Curr Med Res Opin202642149724PubTator, text miningPubMed
Structural insights into cobalamin loading and reactivation of human methionine synthase.Nat Commun202642115646PubTator, text miningPubMed
Arterial and Venous Thrombotic Complications Following Recreational Nitrous Oxide Misuse: A Comprehensive Review.Ann Vasc Surg202642067022PubTator, text miningPubMed
Unmasking Hypercoagulability: Superior Sagittal Sinus Thrombosis Attributed to Pernicious Anemia in a Patient With Normal Hemoglobin Levels.Am J Case Rep202641915627PubTator, text miningPubMed

1 to 10 of 3,187

See all 3,187 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4548

GET https://conductscience.org/api/genes/v1/4548/patents?page=2