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Gene · 4549

MT-RNR1: mitochondrially encoded 12S rRNA

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MT-RNR1: mitochondrially encoded 12S rRNA. Genes, record 4549. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4549

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Gene

Symbol
MT-RNR1
HGNC
Name
mitochondrially encoded 12S rRNA
HGNC
NCBI Gene ID
4549
NCBI Gene
HGNC ID
HGNC:7470
HGNC
Ensembl
ENSG00000211459
NCBI Gene
Aliases
12S, MOTS-c, MTRNR1
NCBI Gene
Type
rRNA
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
A0A0C5B5G6Mitochondrial-derived peptide MOTS-c160HGNC

Source UniProt

Patents110

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12064467 B22024-08-205A0A0C5B5G6Espacenet
US 11753445 B22023-09-122A0A0C5B5G6Espacenet
US 11753445 B22023-09-123A0A0C5B5G6Espacenet
US 11753445 B22023-09-124A0A0C5B5G6Espacenet
US 11753445 B22023-09-125A0A0C5B5G6Espacenet
US 11753445 B22023-09-1269A0A0C5B5G6Espacenet
US 11753445 B22023-09-1270A0A0C5B5G6Espacenet
US 11753445 B22023-09-1271A0A0C5B5G6Espacenet
US 11753445 B22023-09-1272A0A0C5B5G6Espacenet
US 11753445 B22023-09-12103A0A0C5B5G6Espacenet

1 to 10 of 110

See all 110 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants556

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMT-RNR1 papersNewest fiscal year
R01DC012049Optimizing Genetic Testing for Deafness for Clinical Diagnostics72025
R01DC009645A Collaborative Search for New Genes for Non-Syndromic Deafness62025
U24HG010615PharmGKB52025
P30CA008748Cancer Center Support Grant42025
P40OD010440Caenorhabditis Genetics Center42025
U54CA2334653/3 Florida-California Cancer Research, Education and Engagement (CaRE2) Health Center32025
K08DC019716Spiral Ganglion Health: from Genomics to Gene Therapy22025
K24HL133373Discovery, Implementation and Mentorship in Personalized Cardiovascular Pharmacotherapy22025
P30CA076292Moffitt Cancer Center Support Grant22025
P30DK063491Diabetes Research Center (DRC)22025

1 to 10 of 556Source NIH's project files

See all 556 nih grants

Papers1,299

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
digitalMLPA EZtec-MS: A new highly multiplexed DNA probe-based technique for neonatal screening.Eur J Hum Genet202642773160PubTator, text miningPubMed
Mutation Spectrum and Novel Rare Variants in a Han Chinese Hearing Loss Cohort Using a Tiered Sequencing Strategy.Mol Genet Genomic Med202642764263PubTator, text miningPubMed
Novel Variants in Mitochondrial Ribosomal RNA Genes MT-RNR1 and MT-RNR2 Identified in Hereditary Optic Neuropathy Initially Presenting as Normal Tension Glaucoma: A Case Report.Case Rep Ophthalmol202642622002PubTator, text miningPubMed
MT-RNR1 genotype testing for preventing aminoglycoside-mediated ototoxicity: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).Br J Clin Pharmacol202642524757PubTator, text miningPubMed
Managing Secondary Findings from Germline Pharmacogenomic Testing.J Pers Med202642506114PubTator, text miningPubMed
A large-scale multi-ancestry mitochondrial variant association analysis for cardiometabolic traits.Nat Commun202642401575PubTator, text miningPubMed
Mechanisms, prevention, and management of aminoglycoside-induced hearing loss in neonates and children: a translational review.Front Pharmacol202642358372PubTator, text miningPubMed
Genetic Diagnosis of Non-Syndromic Hearing Loss in South Indian Consanguineous Families Using Whole-Exome Sequencing.Medicina (Kaunas)202642356053PubTator, text miningPubMed
Genetic Landscape of Hearing Loss in Brazilian Patients Reveals Population-Specific Variants and Clinical Correlations.Clin Genet202642233699PubTator, text miningPubMed
MOTS-c, a mitochondrial-derived peptide, ameliorates lysosomal membrane permeability and improves survival of soft tissue transplantation.Autophagy202642153537PubTator, text miningPubMed

1 to 10 of 1,299

See all 1,299 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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