Gene · 4552
MTRR: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MTRR: 5-methyltetrahydrofolate-homocysteine methyltransferase reductase. Genes, record 4552. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4552
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UBK8 | Methionine synthase reductase | 698 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 35801 | Q9UBK8 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 13168 | Q9UBK8 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 9048 | Q9UBK8 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7093 | Q9UBK8 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7093 | Q9UBK8 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 13168 | Q9UBK8 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 442 | Q9UBK8 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 9048 | Q9UBK8 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 9048 | Q9UBK8 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 9055 | Q9UBK8 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,026
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MTRR papers | Newest fiscal year |
|---|---|---|---|
| R01AI021150 | Gonococci: Genetics of Resistance to PMN Proteins | 13 | 2025 |
| R01DK045776 | B12 Trafficking and Inherited Defects | 13 | 2025 |
| P30ES009089 | Center for Environmental Health in Northern Manhattan | 8 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 7 | 2025 |
| ZIAHL000225 | Oxidative Modification Of Proteins | 7 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 5 | 2025 |
| ZIACP010121 | Molecular Epidemiology Studies of Occupational and Environmental Exposures | 5 | 2025 |
| ZIAHG000167 | The contribution folate and vitamin B12 genes to disease. | 5 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 4 | 2025 |
1 to 10 of 1,026Source NIH's project files
See all 1,026 nih grantsPapers2,224
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Source-Resolved Wastewater Metagenomics Reveals Distinct Resistome and Virulome Landscapes Across an Urban Wastewater Continuum. | Antibiotics (Basel) | 2026 | 42791967 | PubTator, text mining | PubMed |
| Distribution of ACTN3 R577X, MTHFR C677T, MTHFR A1298C, and MTRR A66G Polymorphisms in 564 School-Aged Children in Beijing: A Cross-Sectional Study. | Genes (Basel) | 2026 | 42650079 | PubTator, text mining | PubMed |
| Where metabolism and virulence meet-sulfoxide reductases as determinants of bacterial survival. | Biochem Soc Trans | 2026 | 42606314 | PubTator, text mining | PubMed |
| Functional MTR and MTRR Variants Show No Association With Nonsyndromic Cleft Lip With or Without Cleft Palate in Chile. | Cleft Palate Craniofac J | 2026 | 42599745 | PubTator, text mining | PubMed |
| Omitting post-alignment processing and merging batch-based imputation: an efficient workflow for NIPT data imputation and its application in maternal folate metabolism genotyping. | J Hum Genet | 2026 | 42581209 | PubTator, text mining | PubMed |
| Development of a Prognostic Model for MACE in Atherosclerosis Based on MTHFR and Serum Markers. | Clin Appl Thromb Hemost | 2026 | 42580670 | PubTator, text mining | PubMed |
| Assessing resistome host range across water reclamation in three geographically distinct communities using Hi-C sequencing. | Appl Environ Microbiol | 2026 | 42505096 | PubTator, text mining | PubMed |
| SLCO1B1 and MTRR gene variants in pediatric acute lymphoblastic leukemia: a study on Egyptian children. | Mol Biol Rep | 2026 | 42484704 | PubTator, text mining | PubMed |
| An integrated Msr-antioxidase-host gene circuit maintains redox homeostasis in legume-rhizobium symbiosis. | Front Plant Sci | 2026 | 42318115 | PubTator, text mining | PubMed |
| Genetic Susceptibility to Autism Spectrum Disorders: Folate Pathway Polymorphisms, Mediterranean Diet and Evolutionary Insights. | J Mol Neurosci | 2026 | 42213268 | PubTator, text mining | PubMed |
1 to 10 of 2,224
See all 2,224 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4552
GET https://conductscience.org/api/genes/v1/4552/patents?page=2