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Gene · 4595

MUTYH: mutY DNA glycosylase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MUTYH: mutY DNA glycosylase. Genes, record 4595. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4595

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Gene

Symbol
MUTYH
HGNC
Name
mutY DNA glycosylase
HGNC
NCBI Gene ID
4595
NCBI Gene
HGNC ID
HGNC:7527
HGNC
Ensembl
ENSG00000132781
NCBI Gene
Aliases
MYH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UIF7Adenine DNA glycosylase5463Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2024123008 A2024-09-107172Q9UIF7Espacenet
US 11504404 B22022-11-22150Q9UIF7Espacenet
US 11446398 B22022-09-2053708Q9UIF7Espacenet
US 11401555 B22022-08-02129Q9UIF7Espacenet
JP 2022524081 A2022-04-27156679Q9UIF7Espacenet
JP 2021169490 A2021-10-28236Q9UIF7Espacenet
JP 2020521748 A2020-07-275Q9UIF7Espacenet
KR 1020200028897 A2020-03-171Q9UIF7Espacenet
US 10584344 B22020-03-10150Q9UIF7Espacenet
EP 3585909 A12020-01-01291Q9UIF7Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,658

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMUTYH papersNewest fiscal year
P30CA008748Cancer Center Support Grant592025
R01CA067985DNA Damage Repair by MUTYH and MUTYH Variants Associated with Colorectal Cancer222025
U01CA167551Colon Cancer Family Registry Cohort222025
P30CA016672Cancer Center Support Grant212025
P30CA006973Regional Oncology Research Center182025
P30CA015704Cancer Center Support Grant152025
P30CA016058Cancer Center Support Grant142025
P01CA092584Structural Cell Biology of DNA Repair Machines132025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant132025
T32ES007059Advanced Training in Environmental Health Sciences132025

1 to 10 of 1,658Source NIH's project files

See all 1,658 nih grants

Papers3,741

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MUTYH Activity Maintains Telomere Stability in Response to Chronic Telomeric 8-Oxoguanine Damage in Cancer Cells.Biomolecules202642793066PubTator, text miningPubMed
Dynamics of mutators of arbitrary dominance in humans.bioRxiv202642779615PubTator, text miningPubMed
MYH gene family associated with high mortality risk in elderly glioma patients with frontal lobe primary site.Brain Res202642778125PubTator, text miningPubMed
From genomic instability to epigenetic regulation: the role of DNA repair gene variants and non-coding RNAs in colorectal carcinogenesis.Nucleosides Nucleotides Nucleic Acids202642770890PubTator, text miningPubMed
Comprehensive Genomic Profiling Reveals the Mutational Spectrum and Clinical Significance of BRCA1/2 and Other Cancer-Susceptibility Genes in Breast Cancer Patients from Southern Tunisia.Cancers (Basel)202642738331PubTator, text miningPubMed
Gastric amphicrine carcinoma in the stomach: an unexpected presentation of MUTYH-associated polyposis.J Pathol Transl Med202642702572PubTator, text miningPubMed
First report of MUTYH-associated polyposis with c.1353_1355del and c.452A>G mutations in Tolima Grande region from Colombia: a case report.Front Oncol202642676843PubTator, text miningPubMed
DNA Damage Recognition by Bacterial and Human Adenine-DNA Glycosylases: Insights from Non-Canonical Substrates.Biomolecules202642650880PubTator, text miningPubMed
The Association of Social and Biological Factors with Clinical Outcomes in Patients with Lung Cancer and DNA Damage Repair Pathway Mutations: A Single-Institution Experience.Cancers (Basel)202642649919PubTator, text miningPubMed
MUTYH activity maintains telomere stability in response to chronic telomeric 8-oxoguanine damage in cancer cells.bioRxiv202642620046PubTator, text miningPubMed

1 to 10 of 3,741

See all 3,741 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4595

GET https://conductscience.org/api/genes/v1/4595/patents?page=2