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Gene · 4598

MVK: mevalonate kinase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MVK: mevalonate kinase. Genes, record 4598. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4598

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Gene

Symbol
MVK
HGNC
Name
mevalonate kinase
HGNC
NCBI Gene ID
4598
NCBI Gene
HGNC ID
HGNC:7530
HGNC
Ensembl
ENSG00000110921
NCBI Gene
Aliases
LRBP, MK, MVLK, POROK3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q03426Mevalonate kinase3961Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19219Q03426Espacenet
JP 2026004568 A2026-01-1453411Q03426Espacenet
EP 4650780 A22025-11-19707Q03426Espacenet
EP 4641201 A22025-10-29496Q03426Espacenet
EP 4641202 A22025-10-294367Q03426Espacenet
JP 2025517969 A2025-06-12496Q03426Espacenet
JP 2025517970 A2025-06-12707Q03426Espacenet
KR 1020250017231 A2025-02-044367Q03426Espacenet
WO 2024214081 A12024-10-17219Q03426Espacenet
US 11634733 B22023-04-259Q03426Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants963

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMVK papersNewest fiscal year
ZIAHG200372Genetics, Pathophysiology, and Treatment of Autoinflammatory and Autoimmune Diseases112025
ZIDAR041180Clinical Support Services for the NIAMS Intramural Research Program92025
P30DK026743UCSF Liver Center52025
P30CA008748Cancer Center Support Grant42025
P30DK063491Diabetes Research Center (DRC)42025
R01DK062370Identifying Genes for Type 2 Diabetes: FUSION42025
ZIEAR041176Clinical Training in Rheumatology42025
R01AI015614Pathogenesis of Fever in Man32025
R01DK113592Sterile inflammation and pyroptotic cell death in liver fibrosis32025
ZIAAI001220Pathogenesis, and Outcome of Autoinflammatory Diseases, NOMID/CAPS, DIRA, CANDLE, SAVI, NLRC4-MAS, Still's-like Diseases, and other Undifferentiated Autoinflammatory Diseases32025

1 to 10 of 963Source NIH's project files

See all 963 nih grants

Papers1,777

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-omics integration reveals tissue-specific biosynthesis of sesquiterpenoids in the medicinal plant Eupatorium lindleyanum.PLoS One202642821537PubTator, text miningPubMed
High-dose short-interval canakinumab therapy for mevalonate kinase deficiency associated with novel MVK variants.Rheumatology (Oxford)202642814885PubTator, text miningPubMed
Postzygotic biallelic inactivation of FDFT1 underlies solitary lesion formation in porokeratosis of Mibelli.J Dermatol Sci202642716848PubTator, text miningPubMed
TiO2-facet-dependent reconstruction of Pt nanoparticles during CO oxidation.Nat Commun202642706282PubTator, text miningPubMed
Floral scent profiling and candidate gene discovery in Hesperis oreophila.Front Plant Sci202642609380PubTator, text miningPubMed
Novel compound heterozygous MVK variants cause early-onset mevalonic aciduria in a Chinese infant.Front Pediatr202642529070PubTator, text miningPubMed
Plasma Proteomics Identifies Proteins and Pathways Associated with Cataract: A Prospective Cohort Study.Ophthalmol Sci202642518793PubTator, text miningPubMed
"Golden flower" development of Aspergillus cristatus determined the sensory characteristic and aroma compounds of Fu brick tea.Int J Food Microbiol202642480482PubTator, text miningPubMed
Multiplex RT-PCR-Based Sequencing Assay to Detect Kidney Cancer-Specific Splice Variants in Tumor Tissues and Plasma Cell-Free RNAs.Mol Diagn Ther202642410176PubTator, text miningPubMed
Genotype-phenotype correlations in autoimmune and autoinflammatory diseases: An NGS-based immunogenetic cohort study.Immunogenetics202642406132PubTator, text miningPubMed

1 to 10 of 1,777

See all 1,777 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4598

GET https://conductscience.org/api/genes/v1/4598/patents?page=2