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Gene · 4600

MX2: MX dynamin like GTPase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MX2: MX dynamin like GTPase 2. Genes, record 4600. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4600

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Gene

Symbol
MX2
HGNC
Name
MX dynamin like GTPase 2
HGNC
NCBI Gene ID
4600
NCBI Gene
HGNC ID
HGNC:7533
HGNC
Ensembl
ENSG00000183486
NCBI Gene
Aliases
MXB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20592Interferon-induced GTP-binding protein Mx27153Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454813P20592Espacenet
EP 4650780 A22025-11-196034P20592Espacenet
EP 4641201 A22025-10-295773P20592Espacenet
EP 4641202 A22025-10-295052P20592Espacenet
JP 2025517969 A2025-06-125773P20592Espacenet
JP 2025517970 A2025-06-126034P20592Espacenet
KR 1020250017231 A2025-02-045052P20592Espacenet
US 12205677 B22025-01-2141P20592Espacenet
US 11446398 B22022-09-2053743P20592Espacenet
JP 2022524081 A2022-04-27156714P20592Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,681

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMX2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant92025
P30CA016086Cancer Center Support Grant92025
R01AI052014HIV-1 Preintegration Trafficking and Nuclear Localization92025
R01AI120860Development of HIV capsid-targeting antivirals that affect immune response by modulating capsid stability and have improved resistance profiles82025
P30AI036214San Diego Center for AIDS Research (SD CFAR)72025
P30CA010815Consolidated Basic Cancer Research Program72025
P51OD010425Washington National Primate Research Center62025
P51OD011132Emory National Primate Research Center62025
UL1TR001863Yale Clinical and Translational Science Award62025
P30AI027763UCSF-Bay Area Center for AIDS Research52025

1 to 10 of 1,681Source NIH's project files

See all 1,681 nih grants

Papers2,393

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
MxB N-Terminus Adopts a Stable α-Helix to Engage the HIV-1 Capsid Trimer Interface.bioRxiv202642818305PubTator, text miningPubMed
Interferon-Associated Antiviral Programs Define LAG-3+ Exhaustion-Like CD8+ T-Cell Remodeling in Influenza a Virus Infection: An Integrative Single-Cell and Multi-Cohort Analysis.Immunol Invest202642533594PubTator, text miningPubMed
MX2 and IRF7 are Associated With Disease Activity and Renal Involvement in Systemic Lupus Erythematosus: An Exploratory Study.J Immunol Res202642504115PubTator, text miningPubMed
The antiviral GTPase MxB is packaged into virions and binds via its N-terminal domain to alphaherpesvirus capsids.PLoS Pathog202642461965PubTator, text miningPubMed
TLR3 activation of microglia-containing cerebral organoid induces antiviral factors against HIV-1 infection.Front Pharmacol202642453569PubTator, text miningPubMed
Altered expression of MX2 and SAMD4A in PBMCs predicts early treatment responses in HBeAg-positive chronic hepatitis B patients during Peg-IFN-α therapy.Front Pharmacol202642440527PubTator, text miningPubMed
Genome-wide transcriptome profiling in crossbred pigs after challenge with Classical Swine Fever Virus.Microb Pathog202642349522PubTator, text miningPubMed
Integrated Downstream Analysis and Epidemiological Modelling of Hantavirus Infection: From Host Transcriptomics to Transmission Dynamics.Pathogens202642347213PubTator, text miningPubMed
Circumvention of acquired resistance to topoisomerase II-targeted anticancer agents in HL-60 leukemia cells by prevention of intronic polyadenylation.J Pharmacol Exp Ther202642258907PubTator, text miningPubMed
Tunneling-Barrier-Free Ohmic Contacts at 2D Electride/Semiconductor Interfaces.ACS Nano202642243069PubTator, text miningPubMed

1 to 10 of 2,393

See all 2,393 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4600

GET https://conductscience.org/api/genes/v1/4600/patents?page=2