ConductScience.org, home

Gene · 4607

MYBPC3: myosin binding protein C3

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. MYBPC3: myosin binding protein C3. Genes, record 4607. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4607

On this page

Gene

Symbol
MYBPC3
HGNC
Name
myosin binding protein C3
HGNC
NCBI Gene ID
4607
NCBI Gene
HGNC ID
HGNC:7551
HGNC
Ensembl
ENSG00000134571
NCBI Gene
Aliases
CMD1MM, CMH4, FHC, LVNC10, MYBP-C, cMyBP-C
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14896Myosin-binding protein C, cardiac-type1,27417Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4824266 A12026-10-2132Q14896Espacenet
EP 4773979 A12026-07-15152Q14896Espacenet
EP 4685489 A22026-01-2823Q14896Espacenet
JP 2026004568 A2026-01-1454564Q14896Espacenet
WO 2025235491 A12025-11-13200Q14896Espacenet
EP 4640849 A22025-10-293092Q14896Espacenet
EP 4641201 A22025-10-2919843Q14896Espacenet
JP 2025519096 A2025-06-243092Q14896Espacenet
JP 2025517969 A2025-06-1219843Q14896Espacenet
JP 2025512333 A2025-04-17815Q14896Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,246

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMYBPC3 papersNewest fiscal year
R01HL105826Fast myosin binding protein-C and cardiac contractility in heart failure592025
R01HL080367Role of Cardiac Myosin Binding Protein-C in the Regulation of Myocardial Contraction332025
T32AR007592Interdisciplinary Training Program in Muscle Biology112025
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs102025
R01HL146676Computer modeling of myosin binding protein C and its effects on cardiac contraction102025
R01HL075619Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies92025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL92025
R01HL141564Structural Dynamics of Cardiac Myosin-Binding Protein C Regulation82025
UL1TR001863Yale Clinical and Translational Science Award82025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology72025

1 to 10 of 2,246Source NIH's project files

See all 2,246 nih grants

Papers3,985

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Extended genotype-phenotype spectrum of 17α-hydroxylase/17,20-lyase deficiency: a nine-case series featuring a novel mutation, suspected TART-like lesions, and multisystem involvement.Front Endocrinol (Lausanne)202642824042PubTator, text miningPubMed
Mapping and rewiring the MYBPC3 promoter for rescue of haploinsufficiency driven hypertrophic cardiomyopathy.bioRxiv202642818042PubTator, text miningPubMed
Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry.Circ Genom Precis Med202642779549PubTator, text miningPubMed
Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes.Mater Today Bio202642765073PubTator, text miningPubMed
Spanish founder variant in MYBPC3: implications of diagnostic criteria, clinical phenotype, and prognosis.Rev Esp Cardiol (Engl Ed)202642763014PubTator, text miningPubMed
Hypertrophic Cardiomyopathy is a Disease of Sarcomere Proteins.Methodist Debakey Cardiovasc J202642761940PubTator, text miningPubMed
Genotype-Phenotype Associations in Pediatric Hypertrophic Cardiomyopathy: A Study From the Pediatric Cardiomyopathy Registry.JACC Heart Fail202642758059PubTator, text miningPubMed
Concomitant PLACK Syndrome, MYBPC3-Related Cardiomyopathy, and Nutritional Deficiency.Pediatr Dermatol202642742298PubTator, text miningPubMed
Natural Missplicing Events Amplified by an Elusive Deep-Intronic MYBPC3 Variant Cause Hypertrophic Cardiomyopathy.Circulation202642741831PubTator, text miningPubMed
Biomechanical stress unmasks a fibroblast-dependent hypercontractile-disarray phenotype in MYBPC3 truncation HCM.APL Bioeng202642741796PubTator, text miningPubMed

1 to 10 of 3,985

See all 3,985 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4607

GET https://conductscience.org/api/genes/v1/4607/patents?page=2