Gene · 4607
MYBPC3: myosin binding protein C3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MYBPC3: myosin binding protein C3. Genes, record 4607. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4607
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14896 | Myosin-binding protein C, cardiac-type | 1,274 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4824266 A1 | 2026-10-21 | 32 | Q14896 | Espacenet |
| EP 4773979 A1 | 2026-07-15 | 152 | Q14896 | Espacenet |
| EP 4685489 A2 | 2026-01-28 | 23 | Q14896 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 54564 | Q14896 | Espacenet |
| WO 2025235491 A1 | 2025-11-13 | 200 | Q14896 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 3092 | Q14896 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 19843 | Q14896 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 3092 | Q14896 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 19843 | Q14896 | Espacenet |
| JP 2025512333 A | 2025-04-17 | 815 | Q14896 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,246
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MYBPC3 papers | Newest fiscal year |
|---|---|---|---|
| R01HL105826 | Fast myosin binding protein-C and cardiac contractility in heart failure | 59 | 2025 |
| R01HL080367 | Role of Cardiac Myosin Binding Protein-C in the Regulation of Myocardial Contraction | 33 | 2025 |
| T32AR007592 | Interdisciplinary Training Program in Muscle Biology | 11 | 2025 |
| R01HL130020 | Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs | 10 | 2025 |
| R01HL146676 | Computer modeling of myosin binding protein C and its effects on cardiac contraction | 10 | 2025 |
| R01HL075619 | Integrative Approach to Divergent Remodeling in Thin Filament Cardiomyopathies | 9 | 2025 |
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 9 | 2025 |
| R01HL141564 | Structural Dynamics of Cardiac Myosin-Binding Protein C Regulation | 8 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 8 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 7 | 2025 |
1 to 10 of 2,246Source NIH's project files
See all 2,246 nih grantsPapers3,985
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Extended genotype-phenotype spectrum of 17α-hydroxylase/17,20-lyase deficiency: a nine-case series featuring a novel mutation, suspected TART-like lesions, and multisystem involvement. | Front Endocrinol (Lausanne) | 2026 | 42824042 | PubTator, text mining | PubMed |
| Mapping and rewiring the MYBPC3 promoter for rescue of haploinsufficiency driven hypertrophic cardiomyopathy. | bioRxiv | 2026 | 42818042 | PubTator, text mining | PubMed |
| Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry. | Circ Genom Precis Med | 2026 | 42779549 | PubTator, text mining | PubMed |
| Genetic vulnerability and dynamic mechanical stress synergistically drive sarcomere failure in human iPSC-derived cardiomyocytes. | Mater Today Bio | 2026 | 42765073 | PubTator, text mining | PubMed |
| Spanish founder variant in MYBPC3: implications of diagnostic criteria, clinical phenotype, and prognosis. | Rev Esp Cardiol (Engl Ed) | 2026 | 42763014 | PubTator, text mining | PubMed |
| Hypertrophic Cardiomyopathy is a Disease of Sarcomere Proteins. | Methodist Debakey Cardiovasc J | 2026 | 42761940 | PubTator, text mining | PubMed |
| Genotype-Phenotype Associations in Pediatric Hypertrophic Cardiomyopathy: A Study From the Pediatric Cardiomyopathy Registry. | JACC Heart Fail | 2026 | 42758059 | PubTator, text mining | PubMed |
| Concomitant PLACK Syndrome, MYBPC3-Related Cardiomyopathy, and Nutritional Deficiency. | Pediatr Dermatol | 2026 | 42742298 | PubTator, text mining | PubMed |
| Natural Missplicing Events Amplified by an Elusive Deep-Intronic MYBPC3 Variant Cause Hypertrophic Cardiomyopathy. | Circulation | 2026 | 42741831 | PubTator, text mining | PubMed |
| Biomechanical stress unmasks a fibroblast-dependent hypercontractile-disarray phenotype in MYBPC3 truncation HCM. | APL Bioeng | 2026 | 42741796 | PubTator, text mining | PubMed |
1 to 10 of 3,985
See all 3,985 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4607
GET https://conductscience.org/api/genes/v1/4607/patents?page=2