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Gene · 4616

GADD45B: growth arrest and DNA damage inducible beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. GADD45B: growth arrest and DNA damage inducible beta. Genes, record 4616. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4616

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Gene

Symbol
GADD45B
HGNC
Name
growth arrest and DNA damage inducible beta
HGNC
NCBI Gene ID
4616
NCBI Gene
HGNC ID
HGNC:4096
HGNC
Ensembl
ENSG00000099860
NCBI Gene
Aliases
DKFZP566B133, GADD45BETA, MYD118
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75293Growth arrest and DNA damage-inducible protein GADD45 beta1600Ensembl, GeneID, HGNC

Source UniProt

Patents44

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16688O75293Espacenet
EP 4650780 A22025-11-19271O75293Espacenet
EP 4641202 A22025-10-294305O75293Espacenet
JP 2025517970 A2025-06-12271O75293Espacenet
KR 1020250017231 A2025-02-044305O75293Espacenet
JP 2024123008 A2024-09-106380O75293Espacenet
US 11708396 B22023-07-252221O75293Espacenet
US 11446398 B22022-09-2036377O75293Espacenet
JP 2022524081 A2022-04-27139348O75293Espacenet
US 11078247 B22021-08-034298O75293Espacenet

1 to 10 of 44

See all 44 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,506

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleGADD45B papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P50AA022538Center for Alcohol Research in Epigenetics82025
P30CA016087Cancer Center Support Grant52025
ZICES102445Gene Expression and Microarrays52025
P01CA108671Myeloproliferative Neoplasms-Research Consortium42025
P30CA008748Cancer Center Support Grant42025
P30CA016056Roswell Park Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
P42ES004911Environmental, Microbial and Mammalian Biomolecular Responses to AhR Ligands42025

1 to 10 of 1,506Source NIH's project files

See all 1,506 nih grants

Papers2,130

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
6PPD-Quinone Promotes Metabolic Dysfunction-Associated Steatotic Liver Disease through Immune-Inflammatory Disruption.Environ Sci Technol202642814397PubTator, text miningPubMed
Deciphering the impact of genetic variants on vulnerability to Opioid Use Disorder.Front Cell Neurosci202642787119PubTator, text miningPubMed
A refined MASH-HCC model identifies macrophage Gadd45b as a key orchestrator of inflammation-driven neoplastic progression.Exp Mol Med202642749878PubTator, text miningPubMed
Gadd45β is critical for regulation of type I interferon signaling by facilitating G3BP-mediated stress granule formation.Cell Rep202642731031PubTator, text miningPubMed
Fermentation with aspergillus costiformis enhances the anti-migratory activity of Aquilaria sinensis leaves with possible involvement of MAPK-related pathways.Food Res Int202642632702PubTator, text miningPubMed
Pathophysiological and translational implications of the dysregulation of molecular machineries controlling RNA metabolism in thyrotropinomas.iScience202642602702PubTator, text miningPubMed
Apoptosis protein markers in comorbid type 2 diabetes mellitus and depression; relationships with cognitive performance, incident dementia, and white matter hyperintensities.J Affect Disord202642556583PubTator, text miningPubMed
Hepatic responses as potential biomarkers of idiosyncratic drug reaction risk.Toxicol Sci202642523165PubTator, text miningPubMed
Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production.Biotechnol Bioeng202642478279PubTator, text miningPubMed
Identification of GADD45B, HMGB3, LMNB2, and MFAP5 as lactylation-related prognostic markers for survival prediction in esophageal cancer.Transl Cancer Res202642445420PubTator, text miningPubMed

1 to 10 of 2,130

See all 2,130 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4616

GET https://conductscience.org/api/genes/v1/4616/patents?page=2