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SERPINC1: serpin family C member 1

1 protein, 192 patents, 15 drugs, 360 trials, 3,744 NIH grants and 23,976 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSERPINC1HGNC
Nameserpin family C member 1HGNC
NCBI Gene ID462NCBI Gene
HGNC IDHGNC:775HGNC
EnsemblENSG00000117601NCBI Gene
AliasesAT3, AT3D, ATIII, ATIII-R2, ATIII-T1, ATIII-T2, MGC22579, THPH7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P01008Antithrombin-III46427Ensembl, GeneID, HGNCUniProt

Patents 192

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4663754 A22025-12-1712P01008Espacenet
EP 4650780 A22025-11-198283P01008Espacenet
JP 2025169942 A2025-11-141269P01008Espacenet
JP 2025147176 A2025-10-0612081P01008Espacenet
JP 2025529142 A2025-09-047685P01008Espacenet
JP 2025525025 A2025-08-011P01008Espacenet
US 12371689 B22025-07-297685P01008Espacenet
JP 2025517970 A2025-06-128283P01008Espacenet
JP 2025028160 A2025-02-2812081P01008Espacenet
EP 4505469 A22025-02-1237P01008Espacenet

Drugs 15

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ARDEPARIN SODIUMCHEMBL1201448Antithrombin-III activatorACTIVATORChEMBL
BEMIPARIN SODIUMCHEMBL2108806Antithrombin-III activatorACTIVATORChEMBL
DALTEPARIN SODIUMCHEMBL1201460Antithrombin-III activatorACTIVATORChEMBL
DANAPAROID SODIUMCHEMBL1201534Antithrombin-III activatorACTIVATORChEMBL
ENOXAPARIN SODIUMCHEMBL1201476Antithrombin-III activatorACTIVATORChEMBL
FITUSIRANCHEMBL4297754Antithrombin mRNA RNAi inhibitorRNAI INHIBITORChEMBL
FONDAPARINUXCHEMBL1201202Antithrombin-III activatorACTIVATORChEMBL
FONDAPARINUX SODIUMCHEMBL1200644Antithrombin-III activatorACTIVATORChEMBL
HEPARINCHEMBL4650299Antithrombin-III activatorACTIVATORChEMBL
HEPARIN CALCIUMCHEMBL1201513Antithrombin-III activatorACTIVATORChEMBL

Trials 360

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07603700TINZAPARIN SODIUMClinicalTrials.gov
NCT07603700DALTEPARIN SODIUMClinicalTrials.gov
NCT07603700ENOXAPARIN SODIUMClinicalTrials.gov
NCT07603700HEPARIN CALCIUMClinicalTrials.gov
NCT07603700HEPARIN SODIUMClinicalTrials.gov
NCT07603700NADROPARIN CALCIUMClinicalTrials.gov
NCT07603700HEPARINClinicalTrials.gov
NCT07494877HEPARIN SODIUMClinicalTrials.gov
NCT07286409HEPARINClinicalTrials.gov
NCT07032025HEPARINEARLY_PHASE1ClinicalTrials.gov

NIH grants 3744

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL101917Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases182,025NIH's project files
T32GM008315Mechanisms of Trauma-Induced Coagulopathy182,025NIH's project files
T32HL007149Research Training in Hematology at UNC Chapel Hill162,025NIH's project files
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI122,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award112,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition112,025NIH's project files
P20GM130460GlyCORE: Glycoscience Center of Research Excellence102,025NIH's project files
R01DK099551New Congenital Disorders of Glycosylation: Therapy and Models102,025NIH's project files
R01HL068835Characterization of an isoform specific anticoagulant function of TFPI-alpha82,025NIH's project files

Papers 23976

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822085PubTator, text miningPubMed
42812221PubTator, text miningPubMed
42792978PubTator, text miningPubMed
42790483PubTator, text miningPubMed
42786025PubTator, text miningPubMed
42780757PubTator, text miningPubMed
42779616PubTator, text miningPubMed
42760619PubTator, text miningPubMed
42758971PubTator, text miningPubMed
42752815PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license