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Gene · 4633

MYL2: myosin light chain 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MYL2: myosin light chain 2. Genes, record 4633. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4633

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Gene

Symbol
MYL2
HGNC
Name
myosin light chain 2
HGNC
NCBI Gene ID
4633
NCBI Gene
HGNC ID
HGNC:7583
HGNC
Ensembl
ENSG00000111245
NCBI Gene
Aliases
CMH10, MFM12, MLC-2, MLC-2s/v, MLC-2v, MLC2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P10916Myosin regulatory light chain 2, ventricular/cardiac muscle isoform1666Ensembl, GeneID, HGNC

Source UniProt

Patents17

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454731P10916Espacenet
US 11446398 B22022-09-2054560P10916Espacenet
JP 2022524081 A2022-04-27157531P10916Espacenet
US 11078247 B22021-08-037169P10916Espacenet
US 10988518 B22021-04-272P10916Espacenet
JP 2019054813 A2019-04-11235166P10916Espacenet
US 10227418 B22019-03-1219P10916Espacenet
JP 2018143144 A2018-09-202P10916Espacenet
JP 2018074996 A2018-05-1725P10916Espacenet
EP 3202904 A12017-08-0919P10916Espacenet

1 to 10 of 17

See all 17 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DANICAMTIVCHEMBL4594304Cardiac myosin activatorACTIVATORChEMBL
MAVACAMTENCHEMBL4297517Cardiac myosin inhibitorINHIBITORChEMBL
OMECAMTIV MECARBILCHEMBL1800955Cardiac myosin activatorACTIVATORChEMBL

Trials45

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants2,528

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMYL2 papersNewest fiscal year
P20GM103424Louisiana Biomedical Research Network162025
R01HL076485Engineering Vascularized Cardiac Muscle102025
R01HL085844Functional interactions of cardiac ion channels92025
P30CA076292Moffitt Cancer Center Support Grant72025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling72025
R01HL131017Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytes72025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology62025
P30CA008748Cancer Center Support Grant62025
P30CA014195Cancer Center Support Grant (CCSG)62025
P30CA016672Cancer Center Support Grant62025

1 to 10 of 2,528Source NIH's project files

See all 2,528 nih grants

Papers3,564

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry.Circ Genom Precis Med202642779549PubTator, text miningPubMed
Structural and Molecular Features of Human Extraocular Muscle Spindles Suggest a Unique Role in Proprioception.Invest Ophthalmol Vis Sci202642742214PubTator, text miningPubMed
HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity.Nat Commun202642697879PubTator, text miningPubMed
Osimertinib-Associated Cardiotoxicity in EGFR-Mutant Non-Small Cell Lung Cancer: Mechanisms, Phenotypes, and Surveillance.Cardiol Rev202642636333PubTator, text miningPubMed
Targeting CYBA inhibits hepatic metastasis of pancreatic cancer through AKT/MLC2 pathway.Acta Pharmacol Sin202642624909PubTator, text miningPubMed
An entosis-anchored hybrid prognostic signature identifies immunotherapy-resistant subgroups in head and neck squamous cell carcinoma.Discov Oncol202642469539PubTator, text miningPubMed
Erlotinib impairs epidermal tight junction and barrier integrity by inhibiting EGFR and Src and affects maturation of cell-cell junctions in human and mouse keratinocytes.Tissue Barriers202642441803PubTator, text miningPubMed
Substrate stiffness regulates HIF-1α signalling via β1-integrin/myosin-2/NF-κB axis.J Transl Med202642421092PubTator, text miningPubMed
Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy.Proc Natl Acad Sci U S A202642372158PubTator, text miningPubMed
Compound Danshen Dripping Pills retards the progression of cerebral cavernous malformations via strengthening vascular integrity and ameliorating inflammatory response.Phytomedicine202642341528PubTator, text miningPubMed

1 to 10 of 3,564

See all 3,564 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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