Gene · 4633
MYL2: myosin light chain 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MYL2: myosin light chain 2. Genes, record 4633. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4633
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P10916 | Myosin regulatory light chain 2, ventricular/cardiac muscle isoform | 166 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents17
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 54731 | P10916 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 54560 | P10916 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 157531 | P10916 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 7169 | P10916 | Espacenet |
| US 10988518 B2 | 2021-04-27 | 2 | P10916 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 235166 | P10916 | Espacenet |
| US 10227418 B2 | 2019-03-12 | 19 | P10916 | Espacenet |
| JP 2018143144 A | 2018-09-20 | 2 | P10916 | Espacenet |
| JP 2018074996 A | 2018-05-17 | 25 | P10916 | Espacenet |
| EP 3202904 A1 | 2017-08-09 | 19 | P10916 | Espacenet |
1 to 10 of 17
See all 17 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials45
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07557498 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07541833 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07529938 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07383025 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07361289 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07210723 | DANICAMTIV | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07168655 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07150299 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07120776 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07107373 | MAVACAMTEN | ClinicalTrials.gov |
1 to 10 of 45
See all 45 trialsNIH grants2,528
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MYL2 papers | Newest fiscal year |
|---|---|---|---|
| P20GM103424 | Louisiana Biomedical Research Network | 16 | 2025 |
| R01HL076485 | Engineering Vascularized Cardiac Muscle | 10 | 2025 |
| R01HL085844 | Functional interactions of cardiac ion channels | 9 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 7 | 2025 |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 7 | 2025 |
| R01HL131017 | Myocardial remuscularization by cardiac patch delivery of epicardial FSTL1 and CCND2 overexpressing cardiomyocytes | 7 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 2,528Source NIH's project files
See all 2,528 nih grantsPapers3,564
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry. | Circ Genom Precis Med | 2026 | 42779549 | PubTator, text mining | PubMed |
| Structural and Molecular Features of Human Extraocular Muscle Spindles Suggest a Unique Role in Proprioception. | Invest Ophthalmol Vis Sci | 2026 | 42742214 | PubTator, text mining | PubMed |
| HDAC inhibition via suberoylanilide hydroxamic acid ameliorates doxorubicin-induced cardiotoxicity. | Nat Commun | 2026 | 42697879 | PubTator, text mining | PubMed |
| Osimertinib-Associated Cardiotoxicity in EGFR-Mutant Non-Small Cell Lung Cancer: Mechanisms, Phenotypes, and Surveillance. | Cardiol Rev | 2026 | 42636333 | PubTator, text mining | PubMed |
| Targeting CYBA inhibits hepatic metastasis of pancreatic cancer through AKT/MLC2 pathway. | Acta Pharmacol Sin | 2026 | 42624909 | PubTator, text mining | PubMed |
| An entosis-anchored hybrid prognostic signature identifies immunotherapy-resistant subgroups in head and neck squamous cell carcinoma. | Discov Oncol | 2026 | 42469539 | PubTator, text mining | PubMed |
| Erlotinib impairs epidermal tight junction and barrier integrity by inhibiting EGFR and Src and affects maturation of cell-cell junctions in human and mouse keratinocytes. | Tissue Barriers | 2026 | 42441803 | PubTator, text mining | PubMed |
| Substrate stiffness regulates HIF-1α signalling via β1-integrin/myosin-2/NF-κB axis. | J Transl Med | 2026 | 42421092 | PubTator, text mining | PubMed |
| Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy. | Proc Natl Acad Sci U S A | 2026 | 42372158 | PubTator, text mining | PubMed |
| Compound Danshen Dripping Pills retards the progression of cerebral cavernous malformations via strengthening vascular integrity and ameliorating inflammatory response. | Phytomedicine | 2026 | 42341528 | PubTator, text mining | PubMed |
1 to 10 of 3,564
See all 3,564 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4633
GET https://conductscience.org/api/genes/v1/4633/patents