Gene · 4634
MYL3: myosin light chain 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MYL3: myosin light chain 3. Genes, record 4634. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4634
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P08590 | Myosin light chain 3 | 195 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents31
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 54732 | P08590 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 54733 | P08590 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 54562 | P08590 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 54563 | P08590 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 157533 | P08590 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 157534 | P08590 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 7170 | P08590 | Espacenet |
| US 10513561 B2 | 2019-12-24 | 6 | P08590 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 235167 | P08590 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 235168 | P08590 | Espacenet |
1 to 10 of 31
See all 31 patentsDrugs3
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials45
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07557498 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07541833 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07529938 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07383025 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07361289 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07210723 | DANICAMTIV | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07168655 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07150299 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07120776 | MAVACAMTEN | ClinicalTrials.gov | ||
| NCT07107373 | MAVACAMTEN | ClinicalTrials.gov |
1 to 10 of 45
See all 45 trialsNIH grants845
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MYL3 papers | Newest fiscal year |
|---|---|---|---|
| R01HL132401 | Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations | 6 | 2025 |
| R01GM029090 | Myosin Gene Diversity and Function | 4 | 2025 |
| R01HL092577 | IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL | 4 | 2025 |
| R01HL105826 | Fast myosin binding protein-C and cardiac contractility in heart failure | 4 | 2025 |
| R01HL113006 | Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling | 4 | 2025 |
| R01HL141371 | Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 3 | 2025 |
| R01CA204484 | Novel Enediyne-Based Antibody-Drug Conjugates for Cancers | 3 | 2025 |
| R01HL130020 | Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs | 3 | 2025 |
1 to 10 of 845Source NIH's project files
See all 845 nih grantsPapers1,322
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry. | Circ Genom Precis Med | 2026 | 42779549 | PubTator, text mining | PubMed |
| Proteomic and Functional Signatures of Phenoconversion in Presymptomatic Amyotrophic Lateral Sclerosis. | J Clin Neuromuscul Dis | 2026 | 42681595 | PubTator, text mining | PubMed |
| Magnetically guided apoptotic mesenchymal stem cell-derived nanovesicles for the modulation of pathological remodeling in cardiac injury. | Acta Biomater | 2026 | 42570782 | PubTator, text mining | PubMed |
| Genetic architecture and cross-platform validation of apolipoprotein A-IV concentrations. | Genome Biol | 2026 | 42449406 | PubTator, text mining | PubMed |
| Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy. | Proc Natl Acad Sci U S A | 2026 | 42372158 | PubTator, text mining | PubMed |
| Leveraging Large and Diverse Biobanks to Evaluate Gene-Disease Associations in Hypertrophic Cardiomyopathy. | J Pers Med | 2026 | 41893039 | PubTator, text mining | PubMed |
| DAB2 in LGMD R2: a molecular link between disease progression and lipid dysregulation. | JCI Insight | 2026 | 41869723 | PubTator, text mining | PubMed |
| Identification of MTURN as a trained immunity-related biomarker for heart failure via integrative transcriptomic machine learning analysis and experimental validation. | Front Immunol | 2026 | 41789108 | PubTator, text mining | PubMed |
| Topological Data Analysis for Unsupervised Feature Selection in Large Scale Spatial Omics Data Sets. | Bull Math Biol | 2026 | 41779089 | PubTator, text mining | PubMed |
| Longitudinal deep multi-omics profiling in a CLN3Δex7/8 minipig model identifies biomarker signatures of disease. | Commun Med (Lond) | 2026 | 41775934 | PubTator, text mining | PubMed |
1 to 10 of 1,322
See all 1,322 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4634
GET https://conductscience.org/api/genes/v1/4634/patents?page=2