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Gene · 4634

MYL3: myosin light chain 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MYL3: myosin light chain 3. Genes, record 4634. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4634

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Gene

Symbol
MYL3
HGNC
Name
myosin light chain 3
HGNC
NCBI Gene ID
4634
NCBI Gene
HGNC ID
HGNC:7584
HGNC
Ensembl
ENSG00000160808
NCBI Gene
Aliases
CMH8, MLC-lV/sb, MLC1SB, MLC1V, VLC1, VLCl
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P08590Myosin light chain 31956Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454732P08590Espacenet
JP 2026004568 A2026-01-1454733P08590Espacenet
US 11446398 B22022-09-2054562P08590Espacenet
US 11446398 B22022-09-2054563P08590Espacenet
JP 2022524081 A2022-04-27157533P08590Espacenet
JP 2022524081 A2022-04-27157534P08590Espacenet
US 11078247 B22021-08-037170P08590Espacenet
US 10513561 B22019-12-246P08590Espacenet
JP 2019054813 A2019-04-11235167P08590Espacenet
JP 2019054813 A2019-04-11235168P08590Espacenet

1 to 10 of 31

See all 31 patents

Drugs3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DANICAMTIVCHEMBL4594304Cardiac myosin activatorACTIVATORChEMBL
MAVACAMTENCHEMBL4297517Cardiac myosin inhibitorINHIBITORChEMBL
OMECAMTIV MECARBILCHEMBL1800955Cardiac myosin activatorACTIVATORChEMBL

Trials45

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants845

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMYL3 papersNewest fiscal year
R01HL132401Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations62025
R01GM029090Myosin Gene Diversity and Function42025
R01HL092577IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVAL42025
R01HL105826Fast myosin binding protein-C and cardiac contractility in heart failure42025
R01HL113006Human Induced Pluripotent Stem Cells for Cardiovascular Disease Modeling42025
R01HL141371Human iPSCs for Elucidating Intercellular Crosstalk Signaling in Dilated Cardiomyopathy42025
UL1TR001863Yale Clinical and Translational Science Award42025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology32025
R01CA204484Novel Enediyne-Based Antibody-Drug Conjugates for Cancers32025
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs32025

1 to 10 of 845Source NIH's project files

See all 845 nih grants

Papers1,322

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clinical Characteristics and Outcomes of Hypertrophic Cardiomyopathy Associated With Thin Filament Variants: Insights From the SHaRe Registry.Circ Genom Precis Med202642779549PubTator, text miningPubMed
Proteomic and Functional Signatures of Phenoconversion in Presymptomatic Amyotrophic Lateral Sclerosis.J Clin Neuromuscul Dis202642681595PubTator, text miningPubMed
Magnetically guided apoptotic mesenchymal stem cell-derived nanovesicles for the modulation of pathological remodeling in cardiac injury.Acta Biomater202642570782PubTator, text miningPubMed
Genetic architecture and cross-platform validation of apolipoprotein A-IV concentrations.Genome Biol202642449406PubTator, text miningPubMed
Thick filament molecular interfaces play a critical role in the pathogenesis of hypertrophic cardiomyopathy.Proc Natl Acad Sci U S A202642372158PubTator, text miningPubMed
Leveraging Large and Diverse Biobanks to Evaluate Gene-Disease Associations in Hypertrophic Cardiomyopathy.J Pers Med202641893039PubTator, text miningPubMed
DAB2 in LGMD R2: a molecular link between disease progression and lipid dysregulation.JCI Insight202641869723PubTator, text miningPubMed
Identification of MTURN as a trained immunity-related biomarker for heart failure via integrative transcriptomic machine learning analysis and experimental validation.Front Immunol202641789108PubTator, text miningPubMed
Topological Data Analysis for Unsupervised Feature Selection in Large Scale Spatial Omics Data Sets.Bull Math Biol202641779089PubTator, text miningPubMed
Longitudinal deep multi-omics profiling in a CLN3Δex7/8 minipig model identifies biomarker signatures of disease.Commun Med (Lond)202641775934PubTator, text miningPubMed

1 to 10 of 1,322

See all 1,322 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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