Gene · 4646
MYO6: myosin VI
12 sourcesgene-search-2026-11-11-0.2.0
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ConductScience Library. MYO6: myosin VI. Genes, record 4646. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4646
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Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9UM54 | Unconventional myosin-VI | 1,294 | 8 | Ensembl, GeneID, HGNC |
Source UniProt
Patents1
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein |
|---|---|---|---|
| WO 2020043864 A1 | 2020-03-05 | 1554 | Q9UM54 |
Source Espacenet
Drugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,335
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MYO6 papers | Newest fiscal year |
|---|---|---|---|
| R01DC012049 | Optimizing Genetic Testing for Deafness for Clinical Diagnostics | 12 | 2025 |
| R35GM126940 | Emergent cellular functions of GPCRs and myosins | 8 | 2025 |
| ZIADC000039 | Identification of Genes Causing Syndromic and Nonsyndromic Hearing Impairment | 6 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 5 | 2025 |
| P30DK034989 | Yale Liver Center | 5 | 2025 |
| R01DC009645 | A Collaborative Search for New Genes for Non-Syndromic Deafness | 5 | 2025 |
| R01EY015625 | Hermansky-Pudlak syndrome and melanosome formation | 5 | 2025 |
| ZIABC011627 | Molecular machines and systems contributing to cancer biology | 5 | 2025 |
| ZIADC000048 | Functional Studies of "Deafness Genes" Essential for Hearing | 5 | 2025 |
| ZIADC000002 | Structural and Molecular Basis of Transduction in Auditory Sensory Organs | 4 | 2025 |
1 to 10 of 1,335Source NIH's project files
See all 1,335 nih grantsPapers1,778
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The RAMP3 proximity interactor MYO6 determines spatiotemporal signaling of the GPCR CLR in lymphatic endothelial cells. | Sci Signal | 2026 | 42743267 | PubTator, text mining | PubMed |
| Myosin VI drives breast cancer progression via SP1/CA9-mediated acidic tumor microenvironment remodeling and subsequent M2 macrophage polarization. | J Immunother Cancer | 2026 | 42532632 | PubTator, text mining | PubMed |
| Uncovering the pivotal role of MYO6 in myocardial infarction: a multimodally validated diagnostic biomarker and immunotherapeutic target. | Front Immunol | 2026 | 42495634 | PubTator, text mining | PubMed |
| β-arrestin and myosin VI cooperatively control glucose-dependent insulinotropic peptide receptor (GIPR) internalization and signaling dynamics. | J Biol Chem | 2026 | 42463051 | PubTator, text mining | PubMed |
| New insights into the complex genetic architecture of age-related hearing loss. | Eur J Med Genet | 2026 | 42379497 | PubTator, text mining | PubMed |
| Integrative genetic and functional analysis of autosomal dominant hearing loss in 108 multigenerational families. | J Mol Med (Berl) | 2026 | 42371110 | PubTator, text mining | PubMed |
| Research Progress of MYO6 Variant-Associated Hereditary Hearing Loss. | J Int Adv Otol | 2026 | 42345434 | PubTator, text mining | PubMed |
| MYO6 and Heart: A Novel Variant in a Deaf Infant With Supraventricular Tachycardia. | Mol Genet Genomic Med | 2026 | 42252530 | PubTator, text mining | PubMed |
| TOM1 family proteins: from cargo sorting to immune dysregulation and cancer. | Cell Commun Signal | 2026 | 42192436 | PubTator, text mining | PubMed |
| Acetylation of STX17 promotes its autophagosomal translocation. | Nat Commun | 2026 | 42062288 | PubTator, text mining | PubMed |
1 to 10 of 1,778
See all 1,778 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
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