ConductScience.org, home

Gene · 4653

MYOC: myocilin

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. MYOC: myocilin. Genes, record 4653. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4653

On this page

Gene

Symbol
MYOC
HGNC
Name
myocilin
HGNC
NCBI Gene ID
4653
NCBI Gene
HGNC ID
HGNC:7610
HGNC
Ensembl
ENSG00000034971
NCBI Gene
Aliases
GLC1A, GPOA, JOAG, JOAG1, TIGR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99972Myocilin50424Ensembl, GeneID, HGNC

Source UniProt

Patents47

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454496Q99972Espacenet
EP 4650780 A22025-11-1970Q99972Espacenet
EP 4640849 A22025-10-297Q99972Espacenet
EP 4641201 A22025-10-2950Q99972Espacenet
JP 2025147176 A2025-10-069133Q99972Espacenet
JP 2025529142 A2025-09-047107Q99972Espacenet
US 12371689 B22025-07-297107Q99972Espacenet
JP 2025519096 A2025-06-247Q99972Espacenet
JP 2025517969 A2025-06-1250Q99972Espacenet
JP 2025517970 A2025-06-1270Q99972Espacenet

1 to 10 of 47

See all 47 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants990

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMYOC papersNewest fiscal year
R01EY021205Characterization of purified myocilin: glaucoma as a protein misfolding disease452025
P30EY005722Center Core Grant for Vision Research312025
P30EY010572Ophthalmology Core Facility282025
P30EY001792P30 Core Grant for Vision Research262025
P30EY014104P30 Core Grant for Vision Research232025
P30EY016665Core Grant for Vision Research232025
ZIAEY000318Molecular Mechanisms Of Glaucoma202025
R01EY019643Extracellular Matrix and Outflow Resistance142025
R01EY022305NEIGHBORHOOD Consortium for POAG Genetics142025
R01EY022359eNOS-Dependent Mechanoregulation of Intraocular Pressure142025

1 to 10 of 990Source NIH's project files

See all 990 nih grants

Papers2,007

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Juvenile and adult open-angle glaucoma form a single polygenic continuum.medRxiv202642780167PubTator, text miningPubMed
The Role of the MYOC Gene in Primary Open Angle Glaucoma in Ethiopia.Clin Exp Ophthalmol202642753158PubTator, text miningPubMed
Genetic Architecture and Clinical Phenotypes of Primary Open-Angle Glaucoma: An Updated Review of Mendelian Genes, GWAS Loci, and Polygenic Risk.Clin Ophthalmol202642751619PubTator, text miningPubMed
ClinGen Glaucoma Variant Curation Expert Panel recommendations enhance classification of myocilin variants.medRxiv202642619956PubTator, text miningPubMed
Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork.bioRxiv202642539143PubTator, text miningPubMed
Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women.EBioMedicine202642537502PubTator, text miningPubMed
Investigating the coupled effects of stiffness and stretch on the trabecular meshwork cells using a hydrogel-integrated microfluidic system.Biomater Sci202642523078PubTator, text miningPubMed
4-phenylbutyric acid-loaded mesoporous silica nanoparticles alleviate endoplasmic reticulum stress and reduce intraocular pressure in glaucoma model.Biol Direct202642477786PubTator, text miningPubMed
Nanoengineering Systems for Gene Therapy: Mechanisms, Modalities, and Future Directions.Int J Mol Sci202642450255PubTator, text miningPubMed
Residential Greenspace and Domestic Gardens, Genetic Predisposition, and Incident Glaucoma: A Prospective Cohort Study.Geohealth202642327851PubTator, text miningPubMed

1 to 10 of 2,007

See all 2,007 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4653

GET https://conductscience.org/api/genes/v1/4653/patents?page=2