Gene · 4653
MYOC: myocilin
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MYOC: myocilin. Genes, record 4653. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4653
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99972 | Myocilin | 504 | 24 | Ensembl, GeneID, HGNC |
Source UniProt
Patents47
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 54496 | Q99972 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 70 | Q99972 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 7 | Q99972 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 50 | Q99972 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 9133 | Q99972 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7107 | Q99972 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7107 | Q99972 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 7 | Q99972 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 50 | Q99972 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 70 | Q99972 | Espacenet |
1 to 10 of 47
See all 47 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants990
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MYOC papers | Newest fiscal year |
|---|---|---|---|
| R01EY021205 | Characterization of purified myocilin: glaucoma as a protein misfolding disease | 45 | 2025 |
| P30EY005722 | Center Core Grant for Vision Research | 31 | 2025 |
| P30EY010572 | Ophthalmology Core Facility | 28 | 2025 |
| P30EY001792 | P30 Core Grant for Vision Research | 26 | 2025 |
| P30EY014104 | P30 Core Grant for Vision Research | 23 | 2025 |
| P30EY016665 | Core Grant for Vision Research | 23 | 2025 |
| ZIAEY000318 | Molecular Mechanisms Of Glaucoma | 20 | 2025 |
| R01EY019643 | Extracellular Matrix and Outflow Resistance | 14 | 2025 |
| R01EY022305 | NEIGHBORHOOD Consortium for POAG Genetics | 14 | 2025 |
| R01EY022359 | eNOS-Dependent Mechanoregulation of Intraocular Pressure | 14 | 2025 |
1 to 10 of 990Source NIH's project files
See all 990 nih grantsPapers2,007
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Juvenile and adult open-angle glaucoma form a single polygenic continuum. | medRxiv | 2026 | 42780167 | PubTator, text mining | PubMed |
| The Role of the MYOC Gene in Primary Open Angle Glaucoma in Ethiopia. | Clin Exp Ophthalmol | 2026 | 42753158 | PubTator, text mining | PubMed |
| Genetic Architecture and Clinical Phenotypes of Primary Open-Angle Glaucoma: An Updated Review of Mendelian Genes, GWAS Loci, and Polygenic Risk. | Clin Ophthalmol | 2026 | 42751619 | PubTator, text mining | PubMed |
| ClinGen Glaucoma Variant Curation Expert Panel recommendations enhance classification of myocilin variants. | medRxiv | 2026 | 42619956 | PubTator, text mining | PubMed |
| Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork. | bioRxiv | 2026 | 42539143 | PubTator, text mining | PubMed |
| Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women. | EBioMedicine | 2026 | 42537502 | PubTator, text mining | PubMed |
| Investigating the coupled effects of stiffness and stretch on the trabecular meshwork cells using a hydrogel-integrated microfluidic system. | Biomater Sci | 2026 | 42523078 | PubTator, text mining | PubMed |
| 4-phenylbutyric acid-loaded mesoporous silica nanoparticles alleviate endoplasmic reticulum stress and reduce intraocular pressure in glaucoma model. | Biol Direct | 2026 | 42477786 | PubTator, text mining | PubMed |
| Nanoengineering Systems for Gene Therapy: Mechanisms, Modalities, and Future Directions. | Int J Mol Sci | 2026 | 42450255 | PubTator, text mining | PubMed |
| Residential Greenspace and Domestic Gardens, Genetic Predisposition, and Incident Glaucoma: A Prospective Cohort Study. | Geohealth | 2026 | 42327851 | PubTator, text mining | PubMed |
1 to 10 of 2,007
See all 2,007 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4653
GET https://conductscience.org/api/genes/v1/4653/patents?page=2