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Gene · 4659

PPP1R12A: protein phosphatase 1 regulatory subunit 12A

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PPP1R12A: protein phosphatase 1 regulatory subunit 12A. Genes, record 4659. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4659

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Gene

Symbol
PPP1R12A
HGNC
Name
protein phosphatase 1 regulatory subunit 12A
HGNC
NCBI Gene ID
4659
NCBI Gene
HGNC ID
HGNC:7618
HGNC
Ensembl
ENSG00000058272
NCBI Gene
Aliases
GUBS, M130, MBS, MYPT1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14974Protein phosphatase 1 regulatory subunit 12A1,0302Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1459899O14974Espacenet
JP 2026004568 A2026-01-1459904O14974Espacenet
EP 4641201 A22025-10-291440O14974Espacenet
JP 2025517969 A2025-06-121440O14974Espacenet
EP 4484957 A12025-01-01166O14974Espacenet
WO 2023162878 A2023-08-31166O14974Espacenet
US 11446398 B22022-09-2068542O14974Espacenet
US 11446398 B22022-09-2068543O14974Espacenet
JP 2022537339 A2022-08-2593O14974Espacenet
JP 2022524081 A2022-04-27171513O14974Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,356

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePPP1R12A papersNewest fiscal year
P30CA008748Cancer Center Support Grant62025
P20GM113132The Institute for Biomolecular Targeting52025
P30CA076292Moffitt Cancer Center Support Grant52025
R01HL060190Metabolic reprogramming of smooth muscle cells in pulmonary hypertension52025
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases52025
P30CA006927Comprehensive Cancer Center Program at Fox Chase42025
P30DK020572Michigan Diabetes Research Center (MDRC)42025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes32025
P30CA014195Cancer Center Support Grant (CCSG)32025
P30CA016672Cancer Center Support Grant32025

1 to 10 of 1,356Source NIH's project files

See all 1,356 nih grants

Papers1,922

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing-switch of MYPT1.Adv Sci (Weinh)202642750313PubTator, text miningPubMed
The emerging function of MYPT1 as a biomarker and therapeutic target.Folia Med (Plovdiv)202642677782PubTator, text miningPubMed
Phenotypic Expansion of PPP1R12A-Related Syndrome: A Novel Splicing Variant Associated with Hearing Loss and Inner Ear Malformations.Genes (Basel)202642650049PubTator, text miningPubMed
PPM1B suppresses cervical carcinoma invasion by dephosphorylating MYPT1 at Thr853 and inactivating the PRMT5 epigenetic axis.Eur J Cell Biol202642585950PubTator, text miningPubMed
Determinants of protein phosphatase 1β substrate specificity for MyPhoNE motif-containing proteins.J Biol Chem202642556723PubTator, text miningPubMed
Morphological, Molecular and Motility Changes in Human Small Intestine After Loop Ileostomy.J Neurogastroenterol Motil202642504660PubTator, text miningPubMed
Small subunit M20 augments inhibitory phosphorylation of MYPT1 in myosin light chain phosphatase by inhibiting autodephosphorylation.Proc Natl Acad Sci U S A202642485392PubTator, text miningPubMed
Epigenome-wide association analysis of prenatal organophosphate ester flame retardant exposure in maternal blood implicates maternal immune and neuronal epigenetic alterations.Environ Int202642424771PubTator, text miningPubMed
Green Tea Polyphenol (-)-Epigallocatechin-3-gallate Protects Endothelial Barrier Function via Myosin Phosphatase and Rho-Kinase.Int J Mol Sci202642352891PubTator, text miningPubMed
Construction of an actin cytoskeleton-related gene signature for predicting prognosis and therapeutic response in glioblastoma: based on machine learning.Transl Cancer Res202642180858PubTator, text miningPubMed

1 to 10 of 1,922

See all 1,922 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4659

GET https://conductscience.org/api/genes/v1/4659/patents?page=2