Gene · 4659
PPP1R12A: protein phosphatase 1 regulatory subunit 12A
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PPP1R12A: protein phosphatase 1 regulatory subunit 12A. Genes, record 4659. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4659
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O14974 | Protein phosphatase 1 regulatory subunit 12A | 1,030 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 59899 | O14974 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 59904 | O14974 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1440 | O14974 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1440 | O14974 | Espacenet |
| EP 4484957 A1 | 2025-01-01 | 166 | O14974 | Espacenet |
| WO 2023162878 A | 2023-08-31 | 166 | O14974 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 68542 | O14974 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 68543 | O14974 | Espacenet |
| JP 2022537339 A | 2022-08-25 | 93 | O14974 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 171513 | O14974 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,356
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PPP1R12A papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P20GM113132 | The Institute for Biomolecular Targeting | 5 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 5 | 2025 |
| R01HL060190 | Metabolic reprogramming of smooth muscle cells in pulmonary hypertension | 5 | 2025 |
| R35GM119455 | Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases | 5 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 4 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 4 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 3 | 2025 |
| P30CA014195 | Cancer Center Support Grant (CCSG) | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,356Source NIH's project files
See all 1,356 nih grantsPapers1,922
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing-switch of MYPT1. | Adv Sci (Weinh) | 2026 | 42750313 | PubTator, text mining | PubMed |
| The emerging function of MYPT1 as a biomarker and therapeutic target. | Folia Med (Plovdiv) | 2026 | 42677782 | PubTator, text mining | PubMed |
| Phenotypic Expansion of PPP1R12A-Related Syndrome: A Novel Splicing Variant Associated with Hearing Loss and Inner Ear Malformations. | Genes (Basel) | 2026 | 42650049 | PubTator, text mining | PubMed |
| PPM1B suppresses cervical carcinoma invasion by dephosphorylating MYPT1 at Thr853 and inactivating the PRMT5 epigenetic axis. | Eur J Cell Biol | 2026 | 42585950 | PubTator, text mining | PubMed |
| Determinants of protein phosphatase 1β substrate specificity for MyPhoNE motif-containing proteins. | J Biol Chem | 2026 | 42556723 | PubTator, text mining | PubMed |
| Morphological, Molecular and Motility Changes in Human Small Intestine After Loop Ileostomy. | J Neurogastroenterol Motil | 2026 | 42504660 | PubTator, text mining | PubMed |
| Small subunit M20 augments inhibitory phosphorylation of MYPT1 in myosin light chain phosphatase by inhibiting autodephosphorylation. | Proc Natl Acad Sci U S A | 2026 | 42485392 | PubTator, text mining | PubMed |
| Epigenome-wide association analysis of prenatal organophosphate ester flame retardant exposure in maternal blood implicates maternal immune and neuronal epigenetic alterations. | Environ Int | 2026 | 42424771 | PubTator, text mining | PubMed |
| Green Tea Polyphenol (-)-Epigallocatechin-3-gallate Protects Endothelial Barrier Function via Myosin Phosphatase and Rho-Kinase. | Int J Mol Sci | 2026 | 42352891 | PubTator, text mining | PubMed |
| Construction of an actin cytoskeleton-related gene signature for predicting prognosis and therapeutic response in glioblastoma: based on machine learning. | Transl Cancer Res | 2026 | 42180858 | PubTator, text mining | PubMed |
1 to 10 of 1,922
See all 1,922 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4659
GET https://conductscience.org/api/genes/v1/4659/patents?page=2