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Gene · 4671

NAIP: NLR family apoptosis inhibitory protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NAIP: NLR family apoptosis inhibitory protein. Genes, record 4671. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4671

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Gene

Symbol
NAIP
HGNC
Name
NLR family apoptosis inhibitory protein
HGNC
NCBI Gene ID
4671
NCBI Gene
HGNC ID
HGNC:7634
HGNC
Ensembl
ENSG00000249437
NCBI Gene
Aliases
BIRC1, NLRB1, psiNAIP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13075Baculoviral IAP repeat-containing protein 11,4032Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2024123008 A2024-09-107358Q13075Espacenet
JP 2024123008 A2024-09-107360Q13075Espacenet
US 11446398 B22022-09-2057173Q13075Espacenet
US 11446398 B22022-09-2057177Q13075Espacenet
JP 2022524081 A2022-04-27160144Q13075Espacenet
JP 2022524081 A2022-04-27160148Q13075Espacenet
US 11078247 B22021-08-037253Q13075Espacenet
US 10501513 B22019-12-107358Q13075Espacenet
US 10501513 B22019-12-107360Q13075Espacenet
US 9907842 B22018-03-0689Q13075Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants967

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNAIP papersNewest fiscal year
P01AI063302The intersection of innate and adaptive immunity to intracellular pathogens102025
R01AI118861Innate immune-mediated control of pulmonary Legionella pneumophila infection72025
R01AI124346Innate immune signaling and stress response72025
R01AI124491NLRP1 and CARD8 Inflammasomes: Assembly, Regulation and Stress Sensing72025
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation72025
R01AI029564Molecular and Functional Analysis of Innate Immune Receptors52025
R01AI165580Elucidating the Structural Mechanisms of NAIP Receptors in Bacterial Detection and Inflammasome Activation52025
P30CA008748Cancer Center Support Grant42025
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer42025
R37AI075039Functional and Structural Dissection of Inflammasome Activation42025

1 to 10 of 967Source NIH's project files

See all 967 nih grants

Papers1,646

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcriptomic Markers of Immunosenescence in Cynomolgus Macaques: A Pilot Study.Genes (Basel)202642650137PubTator, text miningPubMed
Identification of Pyroptosis-Related Gene Signatures Associated with Predicted Immune-Cell Enrichment in Atrial Fibrillation.Genes (Basel)202642650051PubTator, text miningPubMed
Retrospective analysis of spinal muscular atrophy in tunisian population: phenotypic-genotypic associations and considerations for therapeutic advancement.Neurogenetics202642525310PubTator, text miningPubMed
The Co-Evolutionary Arms Race Between Salmonella and the NLRC4 Inflammasome: Immune Recognition and Evasion Strategies.Microorganisms202642514004PubTator, text miningPubMed
Simultaneous Detection of SMN1, SMN2, NAIP, H4F5, and GTF2H2 Copy Numbers and SMN1 Loss-of-Function Variants for SMA by MALDI-TOF Mass Spectrometry.J Mol Diagn202642480849PubTator, text miningPubMed
Spinal muscular atrophy type 2 with severe kyphoscoliosis: a case report.J Med Case Rep202642464403PubTator, text miningPubMed
Induced pluripotent stem cell-derived macrophages enable broad modeling of human inflammasome signaling.Cell Rep Methods202642349410PubTator, text miningPubMed
Supramolecular Assemblies Drive Activation of Inflammasomes.Adv Exp Med Biol202642334537PubTator, text miningPubMed
Identification of potential biological targets in sepsis based on random forest and artificial neural network models.J Infect Dev Ctries202642112730PubTator, text miningPubMed
Unbiased proteomics following inflammasome activation identifies caspase targets in primary intestinal epithelial cells.bioRxiv202642079279PubTator, text miningPubMed

1 to 10 of 1,646

See all 1,646 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4671

GET https://conductscience.org/api/genes/v1/4671/patents?page=2