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Gene · 4688

NCF2: neutrophil cytosolic factor 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NCF2: neutrophil cytosolic factor 2. Genes, record 4688. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4688

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Gene

Symbol
NCF2
HGNC
Name
neutrophil cytosolic factor 2
HGNC
NCBI Gene ID
4688
NCBI Gene
HGNC ID
HGNC:7661
HGNC
Ensembl
ENSG00000116701
NCBI Gene
Aliases
NCF-2, NOXA2, P67-PHOX, P67PHOX, p67phox
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P19878Neutrophil cytosol factor 25267Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455612P19878Espacenet
JP 2026004568 A2026-01-1455613P19878Espacenet
EP 4640849 A22025-10-291246P19878Espacenet
EP 4641201 A22025-10-298426P19878Espacenet
EP 4641202 A22025-10-295398P19878Espacenet
JP 2025519096 A2025-06-241246P19878Espacenet
JP 2025517969 A2025-06-128426P19878Espacenet
KR 1020250017231 A2025-02-045398P19878Espacenet
US 11860162 B22024-01-021219P19878Espacenet
US 11446398 B22022-09-2056733P19878Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,090

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNCF2 papersNewest fiscal year
ZIAAI000646Transgenic Animal Models Of Human Immune Defects232025
ZIAAI000644Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune Deficiencies152025
ZIAAI000645Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies152025
R01AI024717Genetic Linkage in Lupus82025
U54GM104938Oklahoma Shared Clinical and Translational Resources72025
ZIABC010677NADPH Oxidases as Novel Targets for Cancer Therapy72025
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant52025
P30DK020572Michigan Diabetes Research Center (MDRC)52025
P30DK034854Integrated Epithelial and Muscosal Biology52025
P30DK034989Yale Liver Center52025

1 to 10 of 2,090Source NIH's project files

See all 2,090 nih grants

Papers3,069

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Human inborn errors of the phagocyte respiratory burst: Chronic granulomatous disease and beyond.J Hum Immun202642758005PubTator, text miningPubMed
Integration of transcriptomics and machine learning to explore inflammatory characteristics and key oxidative stress-related molecules in nasal polyps.Front Immunol202642718792PubTator, text miningPubMed
Design, synthesis, and pharmacological evaluation of terrein derivatives targeting hepatocellular carcinoma.Eur J Med Chem202642679701PubTator, text miningPubMed
Mepolizumab Modifies Blood Eosinophil Proteome and Transcriptome in Severe Eosinophilic Asthma.Allergy202642655930PubTator, text miningPubMed
Endoplasmic Reticulum Stress-Related Immune Signature in Atrial Fibrillation: Machine Learning and Single-Cell Transcriptomics.J Vis Exp202642611890PubTator, text miningPubMed
Apoptosis-related genes bridge inflammatory bowel disease and osteoporosis: A bioinformatic analysis.PLoS One202642585215PubTator, text miningPubMed
Beneficial effects of antioxidants on neutrophil extracellular trap formation in atherosclerosis.Arch Med Sci202642540628PubTator, text miningPubMed
Integrative Multiomics and Single-cell Profiling Identify Cell-type-resolved Inflammatory Drivers in Symptomatic Irreversible Pulpitis.J Endod202642486295PubTator, text miningPubMed
Expression Profile and Clinical Significance of Ferroptosis-Related Genes in Peripheral Blood Mononuclear Cells of Patients with Systemic Sclerosis.Curr Rheumatol Rev202642459084PubTator, text miningPubMed
Hydrogen sulfide modulates gene networks in hypoxia/reoxygenation-stressed trophoblasts: insights from transcriptome profiling.Front Bioinform202642382641PubTator, text miningPubMed

1 to 10 of 3,069

See all 3,069 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4688

GET https://conductscience.org/api/genes/v1/4688/patents?page=2