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Gene · 4689

NCF4: neutrophil cytosolic factor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NCF4: neutrophil cytosolic factor 4. Genes, record 4689. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4689

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Gene

Symbol
NCF4
HGNC
Name
neutrophil cytosolic factor 4
HGNC
NCBI Gene ID
4689
NCBI Gene
HGNC ID
HGNC:7662
HGNC
Ensembl
ENSG00000100365
NCBI Gene
Aliases
CGD3, NCF, P40PHOX, SH3PXD4, p40phox
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15080Neutrophil cytosol factor 43396Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455619Q15080Espacenet
EP 4641202 A22025-10-294441Q15080Espacenet
EP 4504259 A12025-02-122Q15080Espacenet
KR 1020250017231 A2025-02-044441Q15080Espacenet
US 11446398 B22022-09-2056739Q15080Espacenet
JP 2022524081 A2022-04-27159710Q15080Espacenet
US 11078247 B22021-08-037303Q15080Espacenet
WO 2020043864 A12020-03-051578Q15080Espacenet
WO 2019161400 A12019-08-2213Q15080Espacenet
WO 2019161400 A12019-08-2225Q15080Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,541

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNCF4 papersNewest fiscal year
ZIAAI000646Transgenic Animal Models Of Human Immune Defects202025
ZIAAI000644Gene Therapy and Hematopoietic Stem Cell Research to Treat Inherited Primary Immune Deficiencies142025
ZIAAI000645Development and Clinical Application of Gene and Cell therapies for Patients with Immune Deficiencies132025
P30DK034854Integrated Epithelial and Muscosal Biology62025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital62025
U01DK062413Determining genomic and host-environment contributions to IBD phenotypes62025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations52025
ZIAAI000989Development and conduct of allogeneic stem cell transplant and autologous stem cell gene therapy for inherited immune deficiencies52025
P30CA016672Cancer Center Support Grant42025
P30CA082709Indiana University Melvin and Bren Simon Comprehensive Cancer Center Support Grant42025

1 to 10 of 1,541Source NIH's project files

See all 1,541 nih grants

Papers1,992

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetically engineered porcine liver: a new era in transplantation.Int J Surg202642808109PubTator, text miningPubMed
Human inborn errors of the phagocyte respiratory burst: Chronic granulomatous disease and beyond.J Hum Immun202642758005PubTator, text miningPubMed
Multi-omics analysis identifies macrophage immunometabolic signatures in ulcerative colitis.Front Cell Infect Microbiol202642755516PubTator, text miningPubMed
Integration of transcriptomics and machine learning to explore inflammatory characteristics and key oxidative stress-related molecules in nasal polyps.Front Immunol202642718792PubTator, text miningPubMed
Common Molecular Mechanisms and Candidate Drug Targets in Type 2 Diabetes Mellitus and Atherosclerotic Cardiovascular Disease.J Vis Exp202642612061PubTator, text miningPubMed
Pharmacogenomic variation and chemotherapy-related toxicity profiles in pediatric patients with cancer in Tanzania: a cross-sectional study.Front Pharmacol202642548792PubTator, text miningPubMed
Oxidative DNA Damage as an Integrative Marker of Redox Dysfunction Associated with Doxorubicin-Induced Cardiotoxicity in Pediatric Leukemia.Curr Issues Mol Biol202642353582PubTator, text miningPubMed
Chronic granulomatous disease: Clinical, microbial, and genetic findings in 39 Colombian patients.J Hum Immun202642180170PubTator, text miningPubMed
Discovery of tumor antigens in renal cell carcinoma and prospects for clinical application.Front Immunol202641972142PubTator, text miningPubMed
First review of chronic granulomatous disease in Palestine: clinical and genetic characteristics.Front Immunol202641958672PubTator, text miningPubMed

1 to 10 of 1,992

See all 1,992 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4689

GET https://conductscience.org/api/genes/v1/4689/patents