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Gene · 4690

NCK1: NCK adaptor protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NCK1: NCK adaptor protein 1. Genes, record 4690. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4690

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Gene

Symbol
NCK1
HGNC
Name
NCK adaptor protein 1
HGNC
NCBI Gene ID
4690
NCBI Gene
HGNC ID
HGNC:7664
HGNC
Ensembl
ENSG00000158092
NCBI Gene
Aliases
NCK, NCKalpha, nck-1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16333SH2/SH3 adapter protein NCK137715Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026508272 A2026-03-10140P16333Espacenet
EP 4669653 A12025-12-31140P16333Espacenet
EP 4650780 A22025-11-193379P16333Espacenet
JP 2025517970 A2025-06-123379P16333Espacenet
US 11446398 B22022-09-2055509P16333Espacenet
US 11446398 B22022-09-2055510P16333Espacenet
JP 2022524081 A2022-04-27158480P16333Espacenet
JP 2022524081 A2022-04-27158481P16333Espacenet
JP 2017121240 A2017-07-1352071P16333Espacenet
JP 2017121240 A2017-07-1352073P16333Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,386

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNCK1 papersNewest fiscal year
ZIABC010304Biochemical Basis of T Cell Activation92025
P01AI091580Defining the Unique Properties of the Distinct Signaling Machinery Used by the TCR62025
P30CA016672Cancer Center Support Grant62025
P40OD010440Caenorhabditis Genetics Center62025
P30CA006927Comprehensive Cancer Center Program at Fox Chase52025
P30CA008748Cancer Center Support Grant52025
P30CA014195Cancer Center Support Grant (CCSG)42025
P30CA021765Cancer Center Support Grant (CCSG)42025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital42025
P30CA016042Cancer Center Support Grant32025

1 to 10 of 1,386Source NIH's project files

See all 1,386 nih grants

Papers1,875

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The Y105 phosphosite between the SH3.1 and SH3.2 domains of Nck1 regulates its binding to CD3ϵ.iScience202642621184PubTator, text miningPubMed
Unbranched SPIN90-Arp2/3 actin promotes stress fiber speed and focal adhesion maturation.bioRxiv202642465447PubTator, text miningPubMed
Drugging non-canonical kinases in cancer therapeutics: Molecular targets, underlying mechanisms and small-molecule inhibitors.Acta Pharm Sin B202642453394PubTator, text miningPubMed
Regulation of trophoblast fusion dysfunction in preeclampsia by the NCK1/EIF3D/PPARG axis.Biol Res202642271516PubTator, text miningPubMed
SHIP1 partitions between cortical oscillations and membrane puncta to regulate neutrophil chemotaxis.bioRxiv202642244586PubTator, text miningPubMed
The Regulation and Function of Hippo/YAP Pathway in Cancer.FASEB J202641924992PubTator, text miningPubMed
Maternal opioid use disorder and hepatitis C infection in pregnancy reshape the peripheral immune landscape at term.EBioMedicine202641849830PubTator, text miningPubMed
Molecular mechanisms in podocytopathies: finding suitable targets for a new era of glomerular gene therapy.Clin Kidney J202641788620PubTator, text miningPubMed
Integrative multi-omics defines melanoma drug response networks and ARID1A-dependent resistance mechanisms.Mol Syst Biol202641708984PubTator, text miningPubMed
Rising Star: Exploring Weak Biomolecular Interactions: My Steady and Evolving Journey.J Mol Biol202641655834PubTator, text miningPubMed

1 to 10 of 1,875

See all 1,875 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4690

GET https://conductscience.org/api/genes/v1/4690/patents?page=2