Gene · 4694
NDUFA1: NADH:ubiquinone oxidoreductase subunit A1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NDUFA1: NADH:ubiquinone oxidoreductase subunit A1. Genes, record 4694. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4694
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O15239 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | 70 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents23
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 54915 | O15239 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8945 | O15239 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2801 | O15239 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2801 | O15239 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8945 | O15239 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 55002 | O15239 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3071 | O15239 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 157973 | O15239 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 7346 | O15239 | Espacenet |
| JP 2019054813 A | 2019-04-11 | 235350 | O15239 | Espacenet |
1 to 10 of 23
See all 23 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants416
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NDUFA1 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30ES019776 | HERCULES: Exposome Research Center | 3 | 2025 |
| ZICAG000616 | Analysis of complex biological systems by high-throughput genomic technologies | 3 | 2025 |
| K01AG078485 | Metabolic Vulnerability and Effects of APOE in Human Neurons with Impaired Endocytic Recycling | 2 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 2 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 2 | 2025 |
| P30EY014801 | Miami Center for Vision Research | 2 | 2025 |
| P51OD011092 | Support for National Primate Research Center | 2 | 2025 |
| T32ES012870 | Graduate and Postdoctoral Training in Environmental Health Science and Toxicology | 2 | 2025 |
1 to 10 of 416Source NIH's project files
See all 416 nih grantsPapers500
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mapping metabolic reprogramming dynamics across pancreatic neuroendocrine tumor cell differentiation at single-cell transcriptomic resolution. | Front Genet | 2026 | 42338981 | PubTator, text mining | PubMed |
| Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer's Disease. | Cells | 2026 | 41827885 | PubTator, text mining | PubMed |
| Sex-Specific Prediction Models of Alzheimer's Disease: A Gene Expression Analysis. | Int J Med Sci | 2026 | 41799762 | PubTator, text mining | PubMed |
| Transcriptomic analysis reveals synaptic dysregulation and mitochondrial dysfunction in autism spectrum disorder. | Brain Behav Immun Health | 2026 | 41799280 | PubTator, text mining | PubMed |
| Impacts of Cardiac Dyssynchrony and Resynchronisation on Cellular Metabolism and Mitochondria: Current Understanding for Future Applications. | Arrhythm Electrophysiol Rev | 2026 | 41769196 | PubTator, text mining | PubMed |
| Generative AI Accelerates Genotype-Phenotype Characterization of a 1600-Case Leigh Syndrome Virtual Cohort from Published Literature. | Biology (Basel) | 2026 | 41744643 | PubTator, text mining | PubMed |
| Machine learning-driven identification of shared and disease-specific mitochondria-related genes in COPD, NSCLC, and NSCLC with COPD. | iScience | 2026 | 41732265 | PubTator, text mining | PubMed |
| Recessive variants in mitochondrial complex I nuclear subunits are an underrated cause of optic atrophy. | Brain | 2026 | 41234160 | PubTator, text mining | PubMed |
| A housekeeping gene search to analyze expression changes of individual genes in Macaca mulatta. | Vavilovskii Zhurnal Genet Selektsii | 2025 | 41660605 | PubTator, text mining | PubMed |
| Identification and experimental validation of biomarkers related to mitochondrial and programmed cell death in obsessive-compulsive disorder. | Sci Rep | 2025 | 40885831 | PubTator, text mining | PubMed |
1 to 10 of 500
See all 500 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4694
GET https://conductscience.org/api/genes/v1/4694/patents?page=2