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Gene · 4694

NDUFA1: NADH:ubiquinone oxidoreductase subunit A1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NDUFA1: NADH:ubiquinone oxidoreductase subunit A1. Genes, record 4694. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4694

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Gene

Symbol
NDUFA1
HGNC
Name
NADH:ubiquinone oxidoreductase subunit A1
HGNC
NCBI Gene ID
4694
NCBI Gene
HGNC ID
HGNC:7683
HGNC
Ensembl
ENSG00000125356
NCBI Gene
Aliases
CI-MWFE, MC1DN12, MWFE, ZNF183
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O15239NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1707Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454915O15239Espacenet
EP 4650780 A22025-11-198945O15239Espacenet
JP 2025529142 A2025-09-042801O15239Espacenet
US 12371689 B22025-07-292801O15239Espacenet
JP 2025517970 A2025-06-128945O15239Espacenet
US 11446398 B22022-09-2055002O15239Espacenet
US 11400116 B22022-08-023071O15239Espacenet
JP 2022524081 A2022-04-27157973O15239Espacenet
US 11078247 B22021-08-037346O15239Espacenet
JP 2019054813 A2019-04-11235350O15239Espacenet

1 to 10 of 23

See all 23 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants416

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNDUFA1 papersNewest fiscal year
P30CA016056Roswell Park Cancer Center Support Grant32025
P30ES019776HERCULES: Exposome Research Center32025
ZICAG000616Analysis of complex biological systems by high-throughput genomic technologies32025
K01AG078485Metabolic Vulnerability and Effects of APOE in Human Neurons with Impaired Endocytic Recycling22025
P30AI027763UCSF-Bay Area Center for AIDS Research22025
P30CA043703Case Comprehensive Cancer Center Support Grant22025
P30ES010126UNC Center for Environmental Health and Susceptibility22025
P30EY014801Miami Center for Vision Research22025
P51OD011092Support for National Primate Research Center22025
T32ES012870Graduate and Postdoctoral Training in Environmental Health Science and Toxicology22025

1 to 10 of 416Source NIH's project files

See all 416 nih grants

Papers500

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mapping metabolic reprogramming dynamics across pancreatic neuroendocrine tumor cell differentiation at single-cell transcriptomic resolution.Front Genet202642338981PubTator, text miningPubMed
Estetrol Enhances Mitochondrial Bioenergetics and Neurite Outgrowth in Cellular Models of Alzheimer's Disease.Cells202641827885PubTator, text miningPubMed
Sex-Specific Prediction Models of Alzheimer's Disease: A Gene Expression Analysis.Int J Med Sci202641799762PubTator, text miningPubMed
Transcriptomic analysis reveals synaptic dysregulation and mitochondrial dysfunction in autism spectrum disorder.Brain Behav Immun Health202641799280PubTator, text miningPubMed
Impacts of Cardiac Dyssynchrony and Resynchronisation on Cellular Metabolism and Mitochondria: Current Understanding for Future Applications.Arrhythm Electrophysiol Rev202641769196PubTator, text miningPubMed
Generative AI Accelerates Genotype-Phenotype Characterization of a 1600-Case Leigh Syndrome Virtual Cohort from Published Literature.Biology (Basel)202641744643PubTator, text miningPubMed
Machine learning-driven identification of shared and disease-specific mitochondria-related genes in COPD, NSCLC, and NSCLC with COPD.iScience202641732265PubTator, text miningPubMed
Recessive variants in mitochondrial complex I nuclear subunits are an underrated cause of optic atrophy.Brain202641234160PubTator, text miningPubMed
A housekeeping gene search to analyze expression changes of individual genes in Macaca mulatta.Vavilovskii Zhurnal Genet Selektsii202541660605PubTator, text miningPubMed
Identification and experimental validation of biomarkers related to mitochondrial and programmed cell death in obsessive-compulsive disorder.Sci Rep202540885831PubTator, text miningPubMed

1 to 10 of 500

See all 500 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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