Gene · 4697
COXFA4: cytochrome c oxidase associated subunit FA4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. COXFA4: cytochrome c oxidase associated subunit FA4. Genes, record 4697. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4697
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O00483 | Cytochrome c oxidase subunit FA4 | 81 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 6467 | O00483 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2805 | O00483 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2805 | O00483 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 6467 | O00483 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 55667 | O00483 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 2658 | O00483 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 158638 | O00483 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1591 | O00483 | Espacenet |
| JP 2017121240 A | 2017-07-13 | 52040 | O00483 | Espacenet |
| US 9234895 B2 | 2016-01-12 | 663 | O00483 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants609
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | COXFA4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 2 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 2 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 2 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 2 | 2025 |
| P30ES007033 | University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment | 2 | 2025 |
| R35GM118141 | Mitochondrial Biogenesis in Health and Disease | 2 | 2025 |
1 to 10 of 609Source NIH's project files
See all 609 nih grantsPapers699
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The PON1-NDUFA4 axis maintains mitochondrial respiratory fitness and drives lenvatinib tolerance in hepatocellular carcinoma. | Mol Cancer Res | 2026 | 42518245 | PubTator, text mining | PubMed |
| Micellar curcumol reprograms tumor-associated macrophages and reverses PARP inhibitor resistance in recurrent ovarian cancer. | Phytomedicine | 2026 | 42365697 | PubTator, text mining | PubMed |
| Analysis of gene expression patterns modulated by tuberculous pleural effusion-derived exosomal miRNAs in lung cancer. | Front Genet | 2026 | 42294498 | PubTator, text mining | PubMed |
| COXFA4L2 upregulation preserves residual cytochrome c oxidase activity in COXFA4-related Leigh-like encephalopathy. | Nat Commun | 2026 | 42218136 | PubTator, text mining | PubMed |
| Regulation of mitochondrial ROS by C15ORF48 in a basal cell subpopulation contributes to chemotherapy resistance in TNBC. | Sci Adv | 2026 | 41931605 | PubTator, text mining | PubMed |
| Contrasting Effects of Chronic Glucokinase Activation and Inhibition on Pancreatic Beta-Cell Function. | FASEB J | 2026 | 41891907 | PubTator, text mining | PubMed |
| Temporal lobe epilepsy is associated with neuroinflammation, extracellular matrix remodeling, and synaptic protein alterations. | Front Mol Neurosci | 2026 | 41800185 | PubTator, text mining | PubMed |
| Transcriptomic analysis reveals synaptic dysregulation and mitochondrial dysfunction in autism spectrum disorder. | Brain Behav Immun Health | 2026 | 41799280 | PubTator, text mining | PubMed |
| SPP1+ Macrophages and the Orchestration of Spatially Organized Immunosuppression in Cancer. | Biomedicines | 2026 | 41751193 | PubTator, text mining | PubMed |
| Single-cell analysis reveals the cellular and transcriptional heterogeneity of the normal pediatric thyroid. | Front Endocrinol (Lausanne) | 2026 | 41727685 | PubTator, text mining | PubMed |
1 to 10 of 699
See all 699 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4697
GET https://conductscience.org/api/genes/v1/4697/patents?page=2