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Gene · 4697

COXFA4: cytochrome c oxidase associated subunit FA4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. COXFA4: cytochrome c oxidase associated subunit FA4. Genes, record 4697. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4697

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Gene

Symbol
COXFA4
HGNC
Name
cytochrome c oxidase associated subunit FA4
HGNC
NCBI Gene ID
4697
NCBI Gene
HGNC ID
HGNC:7687
HGNC
Ensembl
ENSG00000189043
NCBI Gene
Aliases
CI-9k, CI-MLRQ, MC4DN21, MISTR1, MLRQ, MRCAF1, NDUFA4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00483Cytochrome c oxidase subunit FA4812Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-196467O00483Espacenet
JP 2025529142 A2025-09-042805O00483Espacenet
US 12371689 B22025-07-292805O00483Espacenet
JP 2025517970 A2025-06-126467O00483Espacenet
US 11446398 B22022-09-2055667O00483Espacenet
US 11400116 B22022-08-022658O00483Espacenet
JP 2022524081 A2022-04-27158638O00483Espacenet
WO 2020043864 A12020-03-051591O00483Espacenet
JP 2017121240 A2017-07-1352040O00483Espacenet
US 9234895 B22016-01-12663O00483Espacenet

1 to 10 of 22

See all 22 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants609

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCOXFA4 papersNewest fiscal year
P30CA008748Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant42025
P30CA016086Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
P30CA016056Roswell Park Cancer Center Support Grant22025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202822025
P30CA068485Cancer Center Support Grant22025
P30CA076292Moffitt Cancer Center Support Grant22025
P30ES007033University of Washington Interdisciplinary Center for Exposures, Diseases, Genomics & Environment22025
R35GM118141Mitochondrial Biogenesis in Health and Disease22025

1 to 10 of 609Source NIH's project files

See all 609 nih grants

Papers699

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The PON1-NDUFA4 axis maintains mitochondrial respiratory fitness and drives lenvatinib tolerance in hepatocellular carcinoma.Mol Cancer Res202642518245PubTator, text miningPubMed
Micellar curcumol reprograms tumor-associated macrophages and reverses PARP inhibitor resistance in recurrent ovarian cancer.Phytomedicine202642365697PubTator, text miningPubMed
Analysis of gene expression patterns modulated by tuberculous pleural effusion-derived exosomal miRNAs in lung cancer.Front Genet202642294498PubTator, text miningPubMed
COXFA4L2 upregulation preserves residual cytochrome c oxidase activity in COXFA4-related Leigh-like encephalopathy.Nat Commun202642218136PubTator, text miningPubMed
Regulation of mitochondrial ROS by C15ORF48 in a basal cell subpopulation contributes to chemotherapy resistance in TNBC.Sci Adv202641931605PubTator, text miningPubMed
Contrasting Effects of Chronic Glucokinase Activation and Inhibition on Pancreatic Beta-Cell Function.FASEB J202641891907PubTator, text miningPubMed
Temporal lobe epilepsy is associated with neuroinflammation, extracellular matrix remodeling, and synaptic protein alterations.Front Mol Neurosci202641800185PubTator, text miningPubMed
Transcriptomic analysis reveals synaptic dysregulation and mitochondrial dysfunction in autism spectrum disorder.Brain Behav Immun Health202641799280PubTator, text miningPubMed
SPP1+ Macrophages and the Orchestration of Spatially Organized Immunosuppression in Cancer.Biomedicines202641751193PubTator, text miningPubMed
Single-cell analysis reveals the cellular and transcriptional heterogeneity of the normal pediatric thyroid.Front Endocrinol (Lausanne)202641727685PubTator, text miningPubMed

1 to 10 of 699

See all 699 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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