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Gene · 4698

NDUFA5: NADH:ubiquinone oxidoreductase subunit A5

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NDUFA5: NADH:ubiquinone oxidoreductase subunit A5. Genes, record 4698. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4698

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Gene

Symbol
NDUFA5
HGNC
Name
NADH:ubiquinone oxidoreductase subunit A5
HGNC
NCBI Gene ID
4698
NCBI Gene
HGNC ID
HGNC:7688
HGNC
Ensembl
ENSG00000128609
NCBI Gene
Aliases
B13, CI-13KD-B, CI-13kB, NUFM, UQOR13
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16718NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 51167Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454924Q16718Espacenet
EP 4650780 A22025-11-197206Q16718Espacenet
JP 2025517970 A2025-06-127206Q16718Espacenet
US 11446398 B22022-09-2055063Q16718Espacenet
JP 2022524081 A2022-04-27158034Q16718Espacenet
WO 2020043864 A12020-03-051592Q16718Espacenet
JP 2019054813 A2019-04-11235359Q16718Espacenet
JP 2017121241 A2017-07-13235359Q16718Espacenet
JP 2015516143 A2015-06-08235359Q16718Espacenet
US 8586006 B22013-11-1914700Q16718Espacenet

1 to 10 of 26

See all 26 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,242

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNDUFA5 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy112025
P30AI060354Harvard University Center for AIDS Research62025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant62025
P30CA008748Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant52025
ZIAAI005024Design Of Immunogens42025
ZIAAI005095HIV Neutralizing Antibodies: Isolation, characterization, and interaction with viral variants42025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202832025
T32AI007387Multidisciplinary HIV Training Program32025
ZIAAI005023Mechanisms Of Humoral Evasion32025

1 to 10 of 1,242Source NIH's project files

See all 1,242 nih grants

Papers1,744

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting Ceramide Metabolism to Overcome Osimertinib Resistance in EGFR-mutant Non-Small Cell Lung Cancer: An In Vitro, Network Pharmacology, and In Silico Study.Anticancer Agents Med Chem202642333846PubTator, text miningPubMed
Integrative analysis of bulk and single-nucleus transcriptomes suggests proteostasis- and metabolism-related alterations in the right ventricular outflow tract of non-syndromic Tetralogy of Fallot.Funct Integr Genomics202642230411PubTator, text miningPubMed
Design, synthesis and biological evaluation of novel imidazo[1,2-a]pyrazine derivatives as potent SYK inhibitors for solid tumor therapy.Bioorg Chem202642184580PubTator, text miningPubMed
Effect of glycosidic torsional energetics on the conformational properties of polysaccharide chains: a Monte Carlo study.Carbohydr Res202642097018PubTator, text miningPubMed
Bi-allelic variants in NDUFA5 cause a mitochondriopathy with complex I deficiency.Am J Hum Genet202641916321PubTator, text miningPubMed
Comprehensive analysis of gp120 glycosylation to explore differences between transmitter/founder and chronic HIV-1 isolates.Glycobiology202641885535PubTator, text miningPubMed
Investigating Metabolically Altered Pathways in Small Cell Lung Cancer: From RNA Sequencing Analysis to Seahorse-Based Functional Validation.Methods Protoc202641874163PubTator, text miningPubMed
Hyaluronic acid degradation by Purpureocillium lilacinum: biochemical and transcriptomic insights.Appl Microbiol Biotechnol202641865196PubTator, text miningPubMed
Identification of respiratory chain complex I deficiency due to NDUFA5 variants as a novel cause of infantile fatal disease.Genes Dis202641859003PubTator, text miningPubMed
Transcriptomic analysis reveals synaptic dysregulation and mitochondrial dysfunction in autism spectrum disorder.Brain Behav Immun Health202641799280PubTator, text miningPubMed

1 to 10 of 1,744

See all 1,744 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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