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ACLY: ATP citrate lyase

1 protein, 76 patents, 1 drug, 26 trials, 2,740 NIH grants and 5,116 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolACLYHGNC
NameATP citrate lyaseHGNC
NCBI Gene ID47NCBI Gene
HGNC IDHGNC:115HGNC
EnsemblENSG00000131473NCBI Gene
AliasesACL, ATPCL, CLATPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P53396ATP-citrate synthase1,10136Ensembl, GeneID, HGNCUniProt

Patents 76

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191470P53396Espacenet
EP 4641201 A22025-10-291084P53396Espacenet
US 12385072 B22025-08-1283P53396Espacenet
JP 2025517969 A2025-06-121084P53396Espacenet
JP 2025517970 A2025-06-121470P53396Espacenet
JP 2025062604 A2025-04-147003P53396Espacenet
JP 2025062604 A2025-04-147008P53396Espacenet
JP 2025024198 A2025-02-199414P53396Espacenet
JP 2024123008 A2024-09-104935P53396Espacenet
US 11892452 B22024-02-067P53396Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BEMPEDOIC ACIDCHEMBL3545313ATP-citrate synthase inhibitorINHIBITORChEMBL

Trials 26

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07474649BEMPEDOIC ACIDPHASE3ClinicalTrials.gov
NCT07440381BEMPEDOIC ACIDPHASE3ClinicalTrials.gov
NCT07282821BEMPEDOIC ACIDPHASE2ClinicalTrials.gov
NCT07256171BEMPEDOIC ACIDClinicalTrials.gov
NCT07239414BEMPEDOIC ACIDPHASE3ClinicalTrials.gov
NCT07201545BEMPEDOIC ACIDPHASE1ClinicalTrials.gov
NCT07182383BEMPEDOIC ACIDPHASE1ClinicalTrials.gov
NCT06780410BEMPEDOIC ACIDPHASE3ClinicalTrials.gov
NCT06450366BEMPEDOIC ACIDPHASE3ClinicalTrials.gov
NCT06035874BEMPEDOIC ACIDClinicalTrials.gov

NIH grants 2740

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant262,025NIH's project files
P30CA008748Cancer Center Support Grant222,025NIH's project files
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes132,025NIH's project files
P30DK019525University of Pennsylvania Diabetes Research Center112,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)102,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology102,025NIH's project files
P30CA010815Consolidated Basic Cancer Research Program92,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant92,025NIH's project files
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant92,025NIH's project files
ZIABC011488Targeting Cancer Through Modifications and Metabolism92,025NIH's project files

Papers 5116

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42801336PubTator, text miningPubMed
42765522PubTator, text miningPubMed
42729398PubTator, text miningPubMed
42726866PubTator, text miningPubMed
42718642PubTator, text miningPubMed
42715328PubTator, text miningPubMed
42708043PubTator, text miningPubMed
42699118PubTator, text miningPubMed
42696454PubTator, text miningPubMed
42686792PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license