Gene · 4700
NDUFA6: NADH:ubiquinone oxidoreductase subunit A6
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NDUFA6: NADH:ubiquinone oxidoreductase subunit A6. Genes, record 4700. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4700
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P56556 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | 128 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents14
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 14253 | P56556 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 14253 | P56556 | Espacenet |
| JP 2024507735 A | 2024-02-21 | 200 | P56556 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 55071 | P56556 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 55082 | P56556 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 55083 | P56556 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 55085 | P56556 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 158042 | P56556 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 158053 | P56556 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 158054 | P56556 | Espacenet |
1 to 10 of 14
See all 14 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants1,046
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NDUFA6 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD008814 | Mammalian iron-sulfur cluster biogenesis | 6 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA010815 | Consolidated Basic Cancer Research Program | 3 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| R01AI080607 | Studies in Poxvirus Host Range Genes and Tropism | 3 | 2025 |
| T32HL007576 | Training in Cardiovascular Research | 3 | 2025 |
| ZIAHD001602 | Regulation Of Intracellular Iron Metabolism | 3 | 2025 |
| P20GM103408 | Idaho INBRE Program | 2 | 2025 |
| P30AI036219 | Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR) | 2 | 2025 |
| P30CA016087 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 1,046Source NIH's project files
See all 1,046 nih grantsPapers1,297
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Identification of mitochondrial energy metabolism-related candidate genes UQCR10 and NDUFA6 in pediatric tetralogy of fallot: an exploratory bioinformatics study. | J Cardiothorac Surg | 2026 | 42289731 | PubTator, text mining | PubMed |
| No Correlation Between Interferon Signaling and Cytosolic Mitochondrial DNA/RNA Leakage in Cultured Skin Fibroblasts of Patients With Mitochondrial Diseases. | Eur J Immunol | 2026 | 41891263 | PubTator, text mining | PubMed |
| Hyaluronic acid degradation by Purpureocillium lilacinum: biochemical and transcriptomic insights. | Appl Microbiol Biotechnol | 2026 | 41865196 | PubTator, text mining | PubMed |
| Exploring Gene Expression Patterns in Alzheimer's Disease Using a Human Microarray Data Meta-Analysis. | Biology (Basel) | 2026 | 41744654 | PubTator, text mining | PubMed |
| Tuning the gate and the gear: The LRRC26 (γ1) subunit modulates intrinsic gating and voltage-sensor coupling of the BK channel. | Proc Natl Acad Sci U S A | 2026 | 41701845 | PubTator, text mining | PubMed |
| Dual-Activity Mannosyltransferase Phosphorylases in Family 130 of Glycoside Hydrolases. | ACS Catal | 2026 | 41561435 | PubTator, text mining | PubMed |
| MCD enzyme deficiency drives early mortality and multiorgan metabolic disruption in Dahl salt-sensitive rats. | iScience | 2026 | 41550752 | PubTator, text mining | PubMed |
| Integrated proteomics and metabolomics reveal phytosesquiterpene lactones inhibit TNBC cell activity by depleting ATP synthesis and reprogramming primary metabolism. | Sci Rep | 2026 | 41530404 | PubTator, text mining | PubMed |
| An Overview of Drug-Resistant Epilepsies Based on Advances in Genetics: A Cohort Study. | Neurol India | 2026 | 41510857 | PubTator, text mining | PubMed |
| Discovery of a small-molecule inhibitor of eIF4E suppressing tumor proliferation via lipid metabolic reprogramming. | J Adv Res | 2026 | 41468962 | PubTator, text mining | PubMed |
1 to 10 of 1,297
See all 1,297 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4700
GET https://conductscience.org/api/genes/v1/4700/patents