Gene · 4705
NDUFA10: NADH:ubiquinone oxidoreductase subunit A10
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NDUFA10: NADH:ubiquinone oxidoreductase subunit A10. Genes, record 4705. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4705
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95299 | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | 355 | 6 | Ensembl, GeneID, HGNC |
Source UniProt
Patents34
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 54916 | O95299 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1407 | O95299 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 9238 | O95299 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 7123 | O95299 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 7123 | O95299 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1407 | O95299 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 9238 | O95299 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 9238 | O95299 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 9245 | O95299 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 55003 | O95299 | Espacenet |
1 to 10 of 34
See all 34 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ME-344 | CHEMBL5314386 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN | CHEMBL1431 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| METFORMIN HYDROCHLORIDE | CHEMBL1703 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
| NV-128 | CHEMBL3545135 | Mitochondrial complex I (NADH dehydrogenase) inhibitor | INHIBITOR | ChEMBL |
Trials1,218
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07604870 | METFORMIN | PHASE2 | ClinicalTrials.gov | |
| NCT07604779 | METFORMIN | ClinicalTrials.gov | ||
| NCT07603505 | METFORMIN | PHASE1 | ClinicalTrials.gov | |
| NCT07589387 | METFORMIN | ClinicalTrials.gov | ||
| NCT07588932 | METFORMIN | EARLY_PHASE1 | ClinicalTrials.gov | |
| NCT07585396 | METFORMIN | PHASE2/PHASE3 | ClinicalTrials.gov | |
| NCT07582471 | METFORMIN | ClinicalTrials.gov | ||
| NCT07520110 | METFORMIN | PHASE3 | ClinicalTrials.gov | |
| NCT07516821 | METFORMIN | ClinicalTrials.gov | ||
| NCT07513480 | METFORMIN | ClinicalTrials.gov |
1 to 10 of 1,218
See all 1,218 trialsNIH grants401
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NDUFA10 papers | Newest fiscal year |
|---|---|---|---|
| P30CA076292 | Moffitt Cancer Center Support Grant | 2 | 2025 |
| P40OD018537 | Bloomington Drosophila Stock Center at Indiana University | 2 | 2025 |
| ZIAHD008967 | Genetic epidemiology of early growth and cardiometabolic diseases | 2 | 2025 |
| K00CA264422 | A visible machine learning system to discover targeted treatment solutions in cancer | 1 | 2025 |
| OT2OD032742 | Bridge2AI: Cell Maps for AI (CM4AI) Data Generation Project | 1 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 1 | 2025 |
| P20GM121176 | Autophagy, Inflammation and Metabolism (AIM) in Disease Center - Phase 2. | 1 | 2025 |
| P20GM121316 | Nebraska Center for Molecular Target Discovery and Development | 1 | 2025 |
| P30AG066507 | Johns Hopkins Alzheimer's Disease Research Center | 1 | 2025 |
| P30AG066512 | Alzheimer's Disease Research Center - Administrative Supplement 2025 | 1 | 2025 |
1 to 10 of 401Source NIH's project files
See all 401 nih grantsPapers494
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Exosomes From Cancer-Associated Fibroblasts Suppress Ferroptosis and CD8+ T Cell Effector Function in Gastric Cancer via miR-4435/NDUFA10 Axis. | FASEB J | 2026 | 42760918 | PubTator, text mining | PubMed |
| Oxidized protein states define metastatic fitness in lung cancer. | bioRxiv | 2026 | 42523302 | PubTator, text mining | PubMed |
| NDUFA10: An Emerging Oncogenic Driver of Metastasis in Lung Adenocarcinoma. | Curr Cancer Drug Targets | 2026 | 41944119 | PubTator, text mining | PubMed |
| Roles of mitochondrial complexes in non-alcoholic fatty liver disease. | Front Mol Biosci | 2026 | 41809730 | PubTator, text mining | PubMed |
| SARS-CoV-2 altered mitochondrial DNA methylation in Indian COVID-19 patients. | Sci Rep | 2026 | 41554758 | PubTator, text mining | PubMed |
| Mass Spectrometry Proteomics: A Key to Faster Drug Discovery. | J Med Chem | 2026 | 41433248 | PubTator, text mining | PubMed |
| Recessive variants in mitochondrial complex I nuclear subunits are an underrated cause of optic atrophy. | Brain | 2026 | 41234160 | PubTator, text mining | PubMed |
| Extruded Limnospira platensis with enzyme supplementation shifts the broiler muscle proteome toward enhanced energy metabolism pathways. | J Proteomics | 2026 | 41033654 | PubTator, text mining | PubMed |
| Linking Personality Traits to Mediterranean Diet Adherence and Exploring Gene-Diet Interactions in Neuroticism. | Nutrients | 2025 | 41374081 | PubTator, text mining | PubMed |
| Bronchoalveolar lavage proteomics in exacerbation of bronchiectasis. | BMC Pulm Med | 2025 | 41034841 | PubTator, text mining | PubMed |
1 to 10 of 494
See all 494 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4705
GET https://conductscience.org/api/genes/v1/4705/patents?page=2