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Gene · 4709

NDUFB3: NADH:ubiquinone oxidoreductase subunit B3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NDUFB3: NADH:ubiquinone oxidoreductase subunit B3. Genes, record 4709. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4709

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Gene

Symbol
NDUFB3
HGNC
Name
NADH:ubiquinone oxidoreductase subunit B3
HGNC
NCBI Gene ID
4709
NCBI Gene
HGNC ID
HGNC:7698
HGNC
Ensembl
ENSG00000119013
NCBI Gene
Aliases
B12, CI-B12, MC1DN25
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43676NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3987Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1454945O43676Espacenet
JP 2026004568 A2026-01-1454946O43676Espacenet
JP 2026004568 A2026-01-1454948O43676Espacenet
EP 4650780 A22025-11-19953O43676Espacenet
JP 2025529142 A2025-09-042810O43676Espacenet
US 12371689 B22025-07-292810O43676Espacenet
JP 2025517970 A2025-06-12953O43676Espacenet
US 11446398 B22022-09-2055117O43676Espacenet
US 11446398 B22022-09-2055119O43676Espacenet
US 11446398 B22022-09-2055120O43676Espacenet

1 to 10 of 27

See all 27 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ME-344CHEMBL5314386Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMINCHEMBL1431Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
METFORMIN HYDROCHLORIDECHEMBL1703Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL
NV-128CHEMBL3545135Mitochondrial complex I (NADH dehydrogenase) inhibitorINHIBITORChEMBL

Trials1,218

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants2,271

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNDUFB3 papersNewest fiscal year
ZIAAI005022Antibody Neutralization Mechanisms192025
P30AI060354Harvard University Center for AIDS Research182025
R01DK045776B12 Trafficking and Inherited Defects172025
ZIAAI005024Design Of Immunogens172025
ZIAAI005095HIV Neutralizing Antibodies: Isolation, characterization, and interaction with viral variants142025
P01AI100148Developing Immunogens to Elicit Broadly Neutralizing anti-HIV-1 Antibodies132025
P30AI027767UAB Center for AIDS Research (CFAR)132025
ZIAAI001090Mechanisms of Effective Humoral Immune Responses to HIV-1122025
P30AI064518Center for AIDS Research112025
P30CA016672Cancer Center Support Grant102025

1 to 10 of 2,271Source NIH's project files

See all 2,271 nih grants

Papers2,987

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Vitamin B12 absorption and factors associated with the response to long-term oral B12 supplementation: a secondary analysis of data from a B12-deficient Indian rural community.Eur J Clin Nutr202642768083PubTator, text miningPubMed
The impact of vitamin B12 deficiency on urinary profile of de novo purine synthesis intermediates: consequences of the methylfolate trap.Nucleosides Nucleotides Nucleic Acids202642343592PubTator, text miningPubMed
Elevated B12/CRP Index as a Simple Prognostic Indicator in Patients with Metastatic Renal Cell Carcinoma Treated with First-Line Targeted Therapy.Biomedicines202642193456PubTator, text miningPubMed
Shared gene signatures between rheumatoid arthritis and Sjögren's syndrome.Am J Clin Exp Immunol202642179742PubTator, text miningPubMed
A Multimodal Approach for Study Diagnosis of MCI and Dementia in the Successful Aging After Elective Surgery (SAGES) Cohort.Am J Geriatr Psychiatry Open Sci Educ Pract202642137496PubTator, text miningPubMed
The acute presentation of nitrous oxide-induced vitamin B-12 deficiency in a postoperative lumbar discectomy patient: illustrative case.J Neurosurg Case Lessons202641911606PubTator, text miningPubMed
Identification and Verification of Mitochondria-Related Diagnostic Markers of Spinal Cord Injury by WGCNA and Machine Learning.Behav Neurol202641810912PubTator, text miningPubMed
Coherent control of (non-)Hermitian mode coupling: tunable chirality and exceptional point dynamics in photonic microresonators.Light Sci Appl202641792106PubTator, text miningPubMed
Vitamin deficiencies and Alzheimer's disease: evidence and implications for supplementation.Front Nutr202641769656PubTator, text miningPubMed
Sensitising PDAC to Gemcitabine by Suppressing NF-κB Pathway and Enhancing Apoptosis.Pharmaceuticals (Basel)202641754784PubTator, text miningPubMed

1 to 10 of 2,987

See all 2,987 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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