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Gene · 4734

NEDD4: NEDD4 E3 ubiquitin protein ligase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NEDD4: NEDD4 E3 ubiquitin protein ligase. Genes, record 4734. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4734

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Gene

Symbol
NEDD4
HGNC
Name
NEDD4 E3 ubiquitin protein ligase
HGNC
NCBI Gene ID
4734
NCBI Gene
HGNC ID
HGNC:7727
HGNC
Ensembl
ENSG00000069869
NCBI Gene
Aliases
KIAA0093, MGC176705, NEDD4-1, RPF1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46934E3 ubiquitin-protein ligase NEDD41,31915Ensembl, GeneID, HGNC

Source UniProt

Patents32

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026509876 A2026-03-2514P46934Espacenet
JP 2026004568 A2026-01-1455253P46934Espacenet
EP 4641201 A22025-10-2917503P46934Espacenet
JP 2025532963 A2025-10-0314P46934Espacenet
EP 4593805 A22025-08-0614P46934Espacenet
JP 2025517969 A2025-06-1217503P46934Espacenet
EP 4540277 A22025-04-2314P46934Espacenet
JP 2025032204 A2025-03-1132200P46934Espacenet
EP 4493157 A22025-01-2217P46934Espacenet
EP 4461818 A22024-11-1332200P46934Espacenet

1 to 10 of 32

See all 32 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,072

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNEDD4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA008748Cancer Center Support Grant122025
R01CA074305Chemical Approaches to Cell Signaling Enzymes72025
P30CA016056Roswell Park Cancer Center Support Grant62025
R01GM058202Ubiquitin-dependent sorting in endosomes and the TGN62025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)52025
P30CA030199Cancer Center Support Grant (CCSG)52025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
R01DK056695SGK Regulation of Epithelial Sodium Transport52025
K12GM068524San Diego IRACDA Scholars Program42025

1 to 10 of 2,072Source NIH's project files

See all 2,072 nih grants

Papers3,453

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
WWP2 in immune surveillance and antigen presentation: context-dependent roles in B cells, T cells, and tumor immune escape.Front Immunol202642812989PubTator, text miningPubMed
Compensatory Mitophagy via NEDD4/HIF-1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα.Adv Sci (Weinh)202642764396PubTator, text miningPubMed
[Identification of immune key genes in sepsis and the regulatory effects of dexmedetomidine based on transcriptome analysis and machine learning].Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi202642750326PubTator, text miningPubMed
Regenerative potential of von Hippel-Lindau tumor suppressor protein.World J Biol Chem202642707860PubTator, text miningPubMed
Regulation of ubiquitination and degradation of the gap junction channel protein Connexin43 involves the concerted action of multiple members of the NEDD4 family of E3 ubiquitin ligases.Cancer Lett202642641867PubTator, text miningPubMed
BLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts.Curr Biol202642636803PubTator, text miningPubMed
P4HA3-mediated hydroxylation of SLC7A11 drives tyrosine kinase inhibitor resistance by suppressing ferroptosis in clear cell renal cell carcinoma.Redox Biol202642607497PubTator, text miningPubMed
SLC25A1-targeted gene therapy attenuates liver fibrosis through NEDD4-mediated ubiquitination and degradation of PPARγ.Pharmacol Res202642586223PubTator, text miningPubMed
Peroxisome proliferator-activated receptor gamma (PPARγ) as a mechano-metabolic transducer: coordinating lipid homeostasis through mechanical cues.Mol Biomed202642584735PubTator, text miningPubMed
GSK3β-mediated phosphorylation of IF1 at Ser27 destabilizes mitochondrial ATP synthase inhibitory factor 1 to aggravate cardiac ischemia/reperfusion injury.Int Immunopharmacol202642574807PubTator, text miningPubMed

1 to 10 of 3,453

See all 3,453 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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GET https://conductscience.org/api/genes/v1/4734/patents?page=2