Gene · 4734
NEDD4: NEDD4 E3 ubiquitin protein ligase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NEDD4: NEDD4 E3 ubiquitin protein ligase. Genes, record 4734. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4734
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P46934 | E3 ubiquitin-protein ligase NEDD4 | 1,319 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents32
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026509876 A | 2026-03-25 | 14 | P46934 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55253 | P46934 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 17503 | P46934 | Espacenet |
| JP 2025532963 A | 2025-10-03 | 14 | P46934 | Espacenet |
| EP 4593805 A2 | 2025-08-06 | 14 | P46934 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 17503 | P46934 | Espacenet |
| EP 4540277 A2 | 2025-04-23 | 14 | P46934 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 32200 | P46934 | Espacenet |
| EP 4493157 A2 | 2025-01-22 | 17 | P46934 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 32200 | P46934 | Espacenet |
1 to 10 of 32
See all 32 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,072
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NEDD4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 15 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| R01CA074305 | Chemical Approaches to Cell Signaling Enzymes | 7 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 6 | 2025 |
| R01GM058202 | Ubiquitin-dependent sorting in endosomes and the TGN | 6 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 5 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| R01DK056695 | SGK Regulation of Epithelial Sodium Transport | 5 | 2025 |
| K12GM068524 | San Diego IRACDA Scholars Program | 4 | 2025 |
1 to 10 of 2,072Source NIH's project files
See all 2,072 nih grantsPapers3,453
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| WWP2 in immune surveillance and antigen presentation: context-dependent roles in B cells, T cells, and tumor immune escape. | Front Immunol | 2026 | 42812989 | PubTator, text mining | PubMed |
| Compensatory Mitophagy via NEDD4/HIF-1α/BNIP3 Pathway Restrains EndMT and Renal Allograft Interstitial Fibrosis Induced by TNFα. | Adv Sci (Weinh) | 2026 | 42764396 | PubTator, text mining | PubMed |
| [Identification of immune key genes in sepsis and the regulatory effects of dexmedetomidine based on transcriptome analysis and machine learning]. | Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi | 2026 | 42750326 | PubTator, text mining | PubMed |
| Regenerative potential of von Hippel-Lindau tumor suppressor protein. | World J Biol Chem | 2026 | 42707860 | PubTator, text mining | PubMed |
| Regulation of ubiquitination and degradation of the gap junction channel protein Connexin43 involves the concerted action of multiple members of the NEDD4 family of E3 ubiquitin ligases. | Cancer Lett | 2026 | 42641867 | PubTator, text mining | PubMed |
| BLTP2 bridges the ER and MVB for exosome biogenesis at SCAMP3-dependent ER contacts. | Curr Biol | 2026 | 42636803 | PubTator, text mining | PubMed |
| P4HA3-mediated hydroxylation of SLC7A11 drives tyrosine kinase inhibitor resistance by suppressing ferroptosis in clear cell renal cell carcinoma. | Redox Biol | 2026 | 42607497 | PubTator, text mining | PubMed |
| SLC25A1-targeted gene therapy attenuates liver fibrosis through NEDD4-mediated ubiquitination and degradation of PPARγ. | Pharmacol Res | 2026 | 42586223 | PubTator, text mining | PubMed |
| Peroxisome proliferator-activated receptor gamma (PPARγ) as a mechano-metabolic transducer: coordinating lipid homeostasis through mechanical cues. | Mol Biomed | 2026 | 42584735 | PubTator, text mining | PubMed |
| GSK3β-mediated phosphorylation of IF1 at Ser27 destabilizes mitochondrial ATP synthase inhibitory factor 1 to aggravate cardiac ischemia/reperfusion injury. | Int Immunopharmacol | 2026 | 42574807 | PubTator, text mining | PubMed |
1 to 10 of 3,453
See all 3,453 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4734
GET https://conductscience.org/api/genes/v1/4734/patents?page=2