Gene · 4738
NEDD8: NEDD8 ubiquitin like modifier
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NEDD8: NEDD8 ubiquitin like modifier. Genes, record 4738. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4738
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q15843 | Ubiquitin-like protein NEDD8 | 81 | 48 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4679090 A1 | 2026-01-14 | 44 | Q15843 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1312 | Q15843 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1312 | Q15843 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 56041 | Q15843 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 159012 | Q15843 | Espacenet |
| KR 1020210100575 A | 2021-08-17 | 1 | Q15843 | Espacenet |
| KR 1020210100575 A | 2021-08-17 | 5 | Q15843 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 7386 | Q15843 | Espacenet |
| KR 1020200132530 A | 2020-11-25 | 1 | Q15843 | Espacenet |
| KR 1020200132530 A | 2020-11-25 | 5 | Q15843 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,862
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NEDD8 papers | Newest fiscal year |
|---|---|---|---|
| P30CA021765 | Cancer Center Support Grant (CCSG) | 37 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 19 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 13 | 2025 |
| ZIABC010441 | Biomolecular Recognition and Binding Mechanisms | 9 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 8 | 2025 |
| P01CA066996 | Development of Novel Therapeutic Strategies in Human Leukemias | 7 | 2025 |
| R01CA218278 | Degrading therapeutically important kinases using small molecules | 7 | 2025 |
| ZIABC010440 | Protein Structure, Stability, and Amyloid Formation | 7 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 6 | 2025 |
1 to 10 of 1,862Source NIH's project files
See all 1,862 nih grantsPapers3,078
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Neddylation-triggered ubiquitination and proteasomal degradation of HELLS inhibits prostate cancer growth via genomic instability. | Biochim Biophys Acta Mol Basis Dis | 2027 | 42607898 | PubTator, text mining | PubMed |
| Neddylation inhibition alleviates polycystic ovary syndrome by regulating granulosa cell function and androgen synthesis. | Biol Reprod | 2026 | 42813898 | PubTator, text mining | PubMed |
| MLN4924 suppresses kidney renal clear cell carcinoma progression through coordinated inhibition of Cullin1 neddylation and PSMB10-associated NF-κB inflammatory signaling. | Inflamm Res | 2026 | 42802181 | PubTator, text mining | PubMed |
| FBXO11 and FBXO32 synergistically activate innate immunity against hepatitis B virus in a NEDD8-dependent manner. | Front Immunol | 2026 | 42756518 | PubTator, text mining | PubMed |
| Chaetocin Induces Ferroptosis in Cisplatin-Resistant Ovarian Cancer Cells Through Neddylation-Mediated TFRC Upregulation. | Phytother Res | 2026 | 42734152 | PubTator, text mining | PubMed |
| PSMA6 drives non-small cell lung cancer progression by stabilizing NEDD8 and activating NF-κB signaling. | Transl Lung Cancer Res | 2026 | 42723894 | PubTator, text mining | PubMed |
| Flavokawain A inhibits high glucose-induced malignant progression of lung cancer cells by suppressing PRMT5-mediated PTEN neddylation and nuclear translocation. | Oncol Lett | 2026 | 42639435 | PubTator, text mining | PubMed |
| Neddylation as a molecular integrator of metabolic dysfunction and endothelial dysfunction in type 2 diabetes. | Acta Pharmacol Sin | 2026 | 42637928 | PubTator, text mining | PubMed |
| Neddylation-dependent RAB40-Cullin5 E3 ligase complex controls ubiquitin-mediated proteasomal degradation of DNAJC13. | BBA Adv | 2026 | 42602476 | PubTator, text mining | PubMed |
| Protein neddylation as a therapeutic target: challenges and opportunities. | J Clin Invest | 2026 | 42544581 | PubTator, text mining | PubMed |
1 to 10 of 3,078
See all 3,078 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4738
GET https://conductscience.org/api/genes/v1/4738/patents?page=2