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Gene · 4738

NEDD8: NEDD8 ubiquitin like modifier

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NEDD8: NEDD8 ubiquitin like modifier. Genes, record 4738. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4738

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Gene

Symbol
NEDD8
HGNC
Name
NEDD8 ubiquitin like modifier
HGNC
NCBI Gene ID
4738
NCBI Gene
HGNC ID
HGNC:7732
HGNC
Ensembl
ENSG00000129559
NCBI Gene
Aliases
NEDD-8, Nedd-8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15843Ubiquitin-like protein NEDD88148Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4679090 A12026-01-1444Q15843Espacenet
EP 4650780 A22025-11-191312Q15843Espacenet
JP 2025517970 A2025-06-121312Q15843Espacenet
US 11446398 B22022-09-2056041Q15843Espacenet
JP 2022524081 A2022-04-27159012Q15843Espacenet
KR 1020210100575 A2021-08-171Q15843Espacenet
KR 1020210100575 A2021-08-175Q15843Espacenet
US 11078247 B22021-08-037386Q15843Espacenet
KR 1020200132530 A2020-11-251Q15843Espacenet
KR 1020200132530 A2020-11-255Q15843Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,862

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNEDD8 papersNewest fiscal year
P30CA021765Cancer Center Support Grant (CCSG)372025
P30CA008748Cancer Center Support Grant192025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control192025
P30CA016672Cancer Center Support Grant132025
ZIABC010441Biomolecular Recognition and Binding Mechanisms92025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202882025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias72025
R01CA218278Degrading therapeutically important kinases using small molecules72025
ZIABC010440Protein Structure, Stability, and Amyloid Formation72025
P30AI027763UCSF-Bay Area Center for AIDS Research62025

1 to 10 of 1,862Source NIH's project files

See all 1,862 nih grants

Papers3,078

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Neddylation-triggered ubiquitination and proteasomal degradation of HELLS inhibits prostate cancer growth via genomic instability.Biochim Biophys Acta Mol Basis Dis202742607898PubTator, text miningPubMed
Neddylation inhibition alleviates polycystic ovary syndrome by regulating granulosa cell function and androgen synthesis.Biol Reprod202642813898PubTator, text miningPubMed
MLN4924 suppresses kidney renal clear cell carcinoma progression through coordinated inhibition of Cullin1 neddylation and PSMB10-associated NF-κB inflammatory signaling.Inflamm Res202642802181PubTator, text miningPubMed
FBXO11 and FBXO32 synergistically activate innate immunity against hepatitis B virus in a NEDD8-dependent manner.Front Immunol202642756518PubTator, text miningPubMed
Chaetocin Induces Ferroptosis in Cisplatin-Resistant Ovarian Cancer Cells Through Neddylation-Mediated TFRC Upregulation.Phytother Res202642734152PubTator, text miningPubMed
PSMA6 drives non-small cell lung cancer progression by stabilizing NEDD8 and activating NF-κB signaling.Transl Lung Cancer Res202642723894PubTator, text miningPubMed
Flavokawain A inhibits high glucose-induced malignant progression of lung cancer cells by suppressing PRMT5-mediated PTEN neddylation and nuclear translocation.Oncol Lett202642639435PubTator, text miningPubMed
Neddylation as a molecular integrator of metabolic dysfunction and endothelial dysfunction in type 2 diabetes.Acta Pharmacol Sin202642637928PubTator, text miningPubMed
Neddylation-dependent RAB40-Cullin5 E3 ligase complex controls ubiquitin-mediated proteasomal degradation of DNAJC13.BBA Adv202642602476PubTator, text miningPubMed
Protein neddylation as a therapeutic target: challenges and opportunities.J Clin Invest202642544581PubTator, text miningPubMed

1 to 10 of 3,078

See all 3,078 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4738

GET https://conductscience.org/api/genes/v1/4738/patents?page=2