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Gene · 4739

NEDD9: neural precursor cell expressed, developmentally down-regulated 9

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NEDD9: neural precursor cell expressed, developmentally down-regulated 9. Genes, record 4739. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4739

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Gene

Symbol
NEDD9
HGNC
Name
neural precursor cell expressed, developmentally down-regulated 9
HGNC
NCBI Gene ID
4739
NCBI Gene
HGNC ID
HGNC:7733
HGNC
Ensembl
ENSG00000111859
NCBI Gene
Aliases
CAS-L, CAS2, CASL, CASS2, HEF1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14511Enhancer of filamentation 18342Ensembl, GeneID, HGNC

Source UniProt

Patents43

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455265Q14511Espacenet
EP 4650780 A22025-11-1910166Q14511Espacenet
EP 4641201 A22025-10-2910464Q14511Espacenet
JP 2025517969 A2025-06-1210464Q14511Espacenet
JP 2025517970 A2025-06-1210166Q14511Espacenet
US 11971411 B22024-04-309Q14511Espacenet
US 11446398 B22022-09-2056045Q14511Espacenet
JP 2022524081 A2022-04-27159016Q14511Espacenet
JP 2019054813 A2019-04-11235700Q14511Espacenet
US 10233498 B22019-03-19134Q14511Espacenet

1 to 10 of 43

See all 43 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,451

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNEDD9 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase572025
ZIALM000073Comparative Analysis Of Completely Sequenced Genomes122025
ZIALM000061Finding Protein Sequence Motifs--Methods And Applications112025
P30CA016672Cancer Center Support Grant72025
R01HL139613Targeting FAK-NEDD9 protein-protein interaction to prevent focal adhesion assembly and vascular proliferation in pulmonary arterial hypertension72025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias42025
P30CA016520Abramson Cancer Center Support Grant42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center42025
P30CA076292Moffitt Cancer Center Support Grant42025
R35GM118160CRISPR Capture, Destroy, and Counter-Attack Mechanisms42025

1 to 10 of 1,451Source NIH's project files

See all 1,451 nih grants

Papers2,045

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Antibody Fc receptor CD16a mediates natural killer cell activation via mechanotransduction of piconewton forces.Sci Adv202642664362PubTator, text miningPubMed
Multidimensional roles of NEDD9 in cancer progression: From molecular regulation to clinical translation.Pathol Res Pract202642579914PubTator, text miningPubMed
Combination AURKA and WEE1 Inhibition Exhibits Efficacy in EGFR or Pan-ERBB Inhibitor-Resistant Head and Neck Squamous Cell Carcinoma.Cancer Res Commun202642531323PubTator, text miningPubMed
Visualizing the interplay of Cas1-Cas2 with DNA replication-repair that creates CRISPR-Cas immunity.Nucleic Acids Res202642258545PubTator, text miningPubMed
YAP1 Upregulates Cytoskeleton Regulator ARHGEF1 and Tissue Regeneration Factor NEDD9 in a Multiplex Proteomic Study.Neurol Int202642188696PubTator, text miningPubMed
Intersection of phenotypic plasticity and anoikis enhances therapeutic vulnerability in prostate cancer.Endocrinology202641992725PubTator, text miningPubMed
Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease Generates Unique Expression Profile Mosaics Within Three Hippocampal Excitatory Neuronal Populations.FASEB J202641930605PubTator, text miningPubMed
Pulmonary Arterial Hypertension in Graves' Disease: Role of Thyroid Autoimmunity and NEDD9.Indian J Endocrinol Metab202641918610PubTator, text miningPubMed
Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, Pathways, and Therapeutic Implications.Neurol Int202641893052PubTator, text miningPubMed
Current Insights into Clinical, Molecular, and Therapeutic Approaches to Acute Respiratory Distress Syndrome.Med Sci (Basel)202641892849PubTator, text miningPubMed

1 to 10 of 2,045

See all 2,045 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4739

GET https://conductscience.org/api/genes/v1/4739/patents?page=2