Gene · 4744
NEFH: neurofilament heavy chain
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NEFH: neurofilament heavy chain. Genes, record 4744. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4744
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P12036 | Neurofilament heavy polypeptide | 1,020 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents49
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 55430 | P12036 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 4368 | P12036 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 4872 | P12036 | Espacenet |
| EP 4583897 A1 | 2025-07-16 | 12 | P12036 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 4368 | P12036 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 32223 | P12036 | Espacenet |
| US 12247986 B2 | 2025-03-11 | 4 | P12036 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 4872 | P12036 | Espacenet |
| US 12156890 B2 | 2024-12-03 | 63 | P12036 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 32223 | P12036 | Espacenet |
1 to 10 of 49
See all 49 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,307
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NEFH papers | Newest fiscal year |
|---|---|---|---|
| U54NS092091 | Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe) | 9 | 2025 |
| R01NS027036 | Disease Mechanism and Therapy in TDP-43 Proteinopathies and Dementias | 8 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| ZIANS003130 | Neuropathogenesis of Retroviral Infections | 5 | 2025 |
| P01AG019724 | Frontotemporal Dementia: Genes, Images, and Emotions | 3 | 2025 |
| P30AG062422 | New Approaches to Dementia Heterogeneity | 3 | 2025 |
| P30AG066515 | Stanford Alzheimer's Disease Research Center | 3 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 3 | 2025 |
| R01GM118847 | Cell signaling through O-GlcNAc reader proteins | 3 | 2025 |
1 to 10 of 1,307Source NIH's project files
See all 1,307 nih grantsPapers2,325
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Bioactive keratin-pectin methacrylate multifilament nerve conduits for functional regeneration across segmental nerve defects. | Int J Biol Macromol | 2026 | 42748994 | PubTator, text mining | PubMed |
| Quantitative Analysis of Axonal Degeneration and TDP-43 Aggregation in Compartmentalized Human iPSC-Derived Motor Neuron-Myotube Co-cultures. | Bio Protoc | 2026 | 42729071 | PubTator, text mining | PubMed |
| Carbon Dot-Engineered Graphene Oxide-Silver Nanoparticle Nanocomposites Orchestrate Conductivity-Redox Coupling for Neuronal Regeneration. | ACS Appl Bio Mater | 2026 | 42705036 | PubTator, text mining | PubMed |
| Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development. | J Cell Biol | 2026 | 42704317 | PubTator, text mining | PubMed |
| Groaning in Progressive Supranuclear Palsy: Insights From a Large Asian Cohort. | Mov Disord Clin Pract | 2026 | 42703087 | PubTator, text mining | PubMed |
| Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer's Disease phenotypes associated with Down Syndrome. | Med Res Arch | 2026 | 42677302 | PubTator, text mining | PubMed |
| Are microcystin-LR and cylindrospermopsin neurotoxic for human cells? An in vitro study on induced pluripotent stem cells-derived models. | Toxicology | 2026 | 42508561 | PubTator, text mining | PubMed |
| Anatomical Characteristics of Tongue-Innervating Mechanoreceptors. | J Comp Neurol | 2026 | 42504741 | PubTator, text mining | PubMed |
| Skin-innervating glutamatergic neurons modulate aging. | Cell | 2026 | 42468523 | PubTator, text mining | PubMed |
| Multiplex Panel Detects Glial and Inflammatory Biomarker Signatures in Sporadic and C9orf72-ALS. | Neurol Neuroimmunol Neuroinflamm | 2026 | 42462180 | PubTator, text mining | PubMed |
1 to 10 of 2,325
See all 2,325 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4744
GET https://conductscience.org/api/genes/v1/4744/patents?page=2