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Gene · 4744

NEFH: neurofilament heavy chain

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NEFH: neurofilament heavy chain. Genes, record 4744. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4744

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Gene

Symbol
NEFH
HGNC
Name
neurofilament heavy chain
HGNC
NCBI Gene ID
4744
NCBI Gene
HGNC ID
HGNC:7737
HGNC
Ensembl
ENSG00000100285
NCBI Gene
Aliases
CMT2CC, NF-H, NFH
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P12036Neurofilament heavy polypeptide1,0200Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455430P12036Espacenet
EP 4641201 A22025-10-294368P12036Espacenet
EP 4641202 A22025-10-294872P12036Espacenet
EP 4583897 A12025-07-1612P12036Espacenet
JP 2025517969 A2025-06-124368P12036Espacenet
JP 2025032204 A2025-03-1132223P12036Espacenet
US 12247986 B22025-03-114P12036Espacenet
KR 1020250017231 A2025-02-044872P12036Espacenet
US 12156890 B22024-12-0363P12036Espacenet
EP 4461818 A22024-11-1332223P12036Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,307

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNEFH papersNewest fiscal year
U54NS092091Clinical Research in ALS and Related Disorders for Therapeutic Development (CReATe)92025
R01NS027036Disease Mechanism and Therapy in TDP-43 Proteinopathies and Dementias82025
P30CA016672Cancer Center Support Grant52025
ZIANS003130Neuropathogenesis of Retroviral Infections52025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions32025
P30AG062422New Approaches to Dementia Heterogeneity32025
P30AG066515Stanford Alzheimer's Disease Research Center32025
P30CA008748Cancer Center Support Grant32025
P30CA076292Moffitt Cancer Center Support Grant32025
R01GM118847Cell signaling through O-GlcNAc reader proteins32025

1 to 10 of 1,307Source NIH's project files

See all 1,307 nih grants

Papers2,325

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Bioactive keratin-pectin methacrylate multifilament nerve conduits for functional regeneration across segmental nerve defects.Int J Biol Macromol202642748994PubTator, text miningPubMed
Quantitative Analysis of Axonal Degeneration and TDP-43 Aggregation in Compartmentalized Human iPSC-Derived Motor Neuron-Myotube Co-cultures.Bio Protoc202642729071PubTator, text miningPubMed
Carbon Dot-Engineered Graphene Oxide-Silver Nanoparticle Nanocomposites Orchestrate Conductivity-Redox Coupling for Neuronal Regeneration.ACS Appl Bio Mater202642705036PubTator, text miningPubMed
Pathogenic KIF1A variants differentially disrupt axonal trafficking and impede synaptic development.J Cell Biol202642704317PubTator, text miningPubMed
Groaning in Progressive Supranuclear Palsy: Insights From a Large Asian Cohort.Mov Disord Clin Pract202642703087PubTator, text miningPubMed
Amyloid precursor protein dosage normalization rescues neurogenesis and Alzheimer's Disease phenotypes associated with Down Syndrome.Med Res Arch202642677302PubTator, text miningPubMed
Are microcystin-LR and cylindrospermopsin neurotoxic for human cells? An in vitro study on induced pluripotent stem cells-derived models.Toxicology202642508561PubTator, text miningPubMed
Anatomical Characteristics of Tongue-Innervating Mechanoreceptors.J Comp Neurol202642504741PubTator, text miningPubMed
Skin-innervating glutamatergic neurons modulate aging.Cell202642468523PubTator, text miningPubMed
Multiplex Panel Detects Glial and Inflammatory Biomarker Signatures in Sporadic and C9orf72-ALS.Neurol Neuroimmunol Neuroinflamm202642462180PubTator, text miningPubMed

1 to 10 of 2,325

See all 2,325 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4744

GET https://conductscience.org/api/genes/v1/4744/patents?page=2